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Kyriakos Kachrimanis
Aristotle University of Thessaloniki
Analytical chemistryChemistryParticle sizeChromatographyPolymer
52Publications
21H-index
1,035Citations
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Publications 58
Newest
#1Afroditi Kapourani (A.U.Th.: Aristotle University of Thessaloniki)
#2Elisavet Vardaka (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
Last. Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
view all 5 authors...
Abstract The correlation between glass forming ability (GFA) and several thermophysical or physicochemical properties of APIs with the formation and the physical stability of amorphous solid dispersions (ASDs) was evaluated in the present study. Eight poorly water-soluble APIs belonging in different GFA classes (i.e. a) GFA Class I: Carbamazepine, CBZ, b) GFA Class II: Agomelatine, AGO, Aprepitant, APT, Rivaroxaban, RIV, and c) GFA Class III: Indomethacin, IND, Pioglitazone, PIO, Piroxixam, PIR,...
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#1Konstantinos Katopodis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2Afroditi Kapourani (A.U.Th.: Aristotle University of Thessaloniki)
Last. Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
view all 9 authors...
Abstract The present study evaluates the effect of several pharmaceutical plasticizers on the thermo-physical and physicochemical properties of partially hydrolyzed poly(vinyl alcohol) (PVA) used in fusion-based pharmaceutical formulation processes. Specifically, the effect of mannitol (MAN), sorbitol (SOR), sucrose (SUC), anhydrous citric acid (CA), triethyl citrate (TEC) and low-molecular weight polyethylene glycol (PEG400) on PVA’s melting properties, physical state and thermal degradation wa...
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#1Djordje MedarevićH-Index: 6
#2Svetlana IbrićH-Index: 19
Last. Kyriakos KachrimanisH-Index: 21
view all 6 authors...
Nanocrystal formation for the dissolution enhancement of glimepiride was attempted by wet media milling. Different stabilizers were tested and the obtained nanosuspensions were solidified by spray drying in presence of mannitol, and characterized regarding their redispersibility by dynamic light scattering, physicochemical properties by differential scanning calorimetry (DSC), FT-IR spectroscopy, powder X-ray diffraction (PXRD), and scanning electron microcopy (SEM), as well as dissolution rate....
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#1Afroditi Kapourani (A.U.Th.: Aristotle University of Thessaloniki)
#2Elisavet Vardaka (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
Last. Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
view all 5 authors...
Abstract The present study evaluates the physical stability and intermolecular interactions of Rivaroxaban (RXB) amorphous solid dispersions (ASDs) in polymeric carriers via thermodynamic modelling and molecular simulations. Specifically, the Flory-Huggins (FH) lattice solution theory was used to construct thermodynamic phase diagrams of RXB ASDs in four commonly used polymeric carriers (i.e. copovidone, coPVP, povidone, PVP, Soluplus, SOL and hypromellose acetate succinate, HPMCAS), which were ...
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#1Djordje MedarevićH-Index: 6
#2Jelena DjurisH-Index: 9
Last. Svetlana IbrićH-Index: 19
view all 5 authors...
The development of stable solid dispersion formulations that maintain desired improvement of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer solubility and miscibility. Only if the drug concentration is below the solubility limit in the polymer, the physical stability of solid dispersions is guaranteed without risk for drug (re)crystallization. If the drug concentration is above the solubility, but below the miscibility limit, the system is stabilized thr...
2 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Elisavet Vardaka (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 4 authors...
Abstract In the present work molecular mobility and intermolecular interactions were evaluated as two distinct mechanisms for amorphous agomelatine (AGM) stabilization in the presence of pyrogenic silica. Specifically, amorphous AGM properties related to molecular mobility in terms of relaxation time were calculated based on the Kohlrausch–Williams–Watts (KWW) and Adam-Gibbs (AG) equations, while the kinetic fragility index was calculated based on temperature-modulated differential scanning calo...
1 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 5 authors...
Abstract A realistic molecular description of amorphous drug-polymer-plasticizer matrices, suitable for the preparation of amorphous solid dispersions (ASDs) with the aid of fusion-based techniques, was evaluated. Specifically, the incorporation of two model drugs (i.e. ibuprofen, IBU, and carbamazepine, CBZ) having substantially different thermal properties and glass forming ability, on the molecular representation of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol graft copolymer (...
2 CitationsSource
#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 4 authors...
Abstract In the present study, the preparation of pharmaceutical mini-tablets was attempted in the framework of Quality by Design (QbD) context, by comparing traditionally used multi-linear regression (MLR), with artificially-intelligence based regression techniques (such as standard artificial neural networks (ANNs), particle swarm optimization (PSO) ANNs and genetic programming (GP)) during Design of Experiment (DoE) implementation. Specifically, the effect of diluent type and particle size fr...
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#1Panagiotis Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 9
#2Anna Karagianni (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 3
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 4 authors...
Abstract The aim of the present study was to evaluate the thermodynamic properties of in-situ formation of cocrystal formulations by the melt-mixing method. Specifically, the thermodynamic mixing behaviour of carbamazepine-nicotinamide and ibuprofen-nicotinamide cocrystals prepared with the aid of Soluplus® (SOL) were evaluated using thermodynamic lattice-based solution theories. Thermodynamic miscibility of both cocrystals with SOL was predicted by calculating Gibb′s free energy based on the Fl...
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#1P. Barmpalexis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
#2P. Syllignaki (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 1
Last. Kyriakos Kachrimanis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 21
view all 3 authors...
AbstractWater diffusion through the matrix of three superdisintegrants, namely sodium starch glycolate (SSG), croscarmellose sodium (cCMC-Na) and crospovidone (cPVP), was studied at the sub-molecular level using Attenuated Total Reflectance (ATR)–FTIR spectroscopy and molecular dynamics simulations, and the results were correlated to water uptake studies conducted at the particulate level using Parallel Exponential Kinetics (PEK) modeling in dynamic moisture sorption studies and optical microsco...
2 CitationsSource
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