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Moses Ngari
Wellcome Trust
33Publications
9H-index
226Citations
Publications 36
Newest
#1Alison Talbert (Wellcome Trust)H-Index: 8
#2Moses Ngari (Wellcome Trust)H-Index: 9
Last.James A. BerkleyH-Index: 41
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There is an increasing recognition that children remain at elevated risk of death following discharge from health facilities in resource-poor settings. Diarrhea has previously been highlighted as a risk factor for post-discharge mortality. A retrospective cohort study was conducted to estimate the incidence and demographic, clinical, and biochemical features associated with inpatient and 1-year post-discharge mortality amongst children aged 2–59 months admitted with diarrhea from 2007 to 2015 at...
1 CitationsSource
#1James M. Njunge (Wellcome Trust)H-Index: 4
#2Agnes Gwela (Wellcome Trust)H-Index: 2
Last.James A. Berkley (University of Oxford)H-Index: 41
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High mortality after discharge from hospital following acute illness has been observed among children with Severe Acute Malnutrition (SAM). However, mechanisms that may be amenable to intervention to reduce risk are unknown. We performed a nested case-control study among HIV-uninfected children aged 2–59 months treated for complicated SAM according to WHO recommendations at four Kenyan hospitals. Blood was drawn from 1778 children when clinically judged stable before discharge from hospital. Cas...
1 CitationsSource
#1Gerard Bryan Gonzales (UGent: Ghent University)H-Index: 11
#2Moses Ngari (Wellcome Trust)H-Index: 9
Last.James A. Berkley (University of Oxford)H-Index: 41
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#1Natalia Hounsome (BSMS: Brighton and Sussex Medical School)H-Index: 9
#2Meseret Molla Kassahun (College of Health Sciences, Bahrain)
Last.Gail Davey (AAU: Addis Ababa University)H-Index: 37
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Background Podoconiosis is a disease of the lymphatic vessels of the lower extremities that is caused by chronic exposure to irritant soils. It results in leg swelling, commonly complicated by acute dermatolymphangioadenitis (ADLA), characterised by severe pain, fever and disability. Methods We conducted cost-effectiveness and social outcome analyses of a pragmatic, randomised controlled trial of a hygiene and foot-care intervention for people with podoconiosis in the East Gojjam zone of norther...
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#1Osman AbdullahiH-Index: 5
#2Moses NgariH-Index: 9
view all 5 authors...
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#1Moses Ngari (Wellcome Trust)H-Index: 9
#2Osman Abdullahi (Pwani University College)
Last.Annie Willetts (Pwani University College)
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Background Despite introduction of rapid and accurate diagnostic tools and aggressive treatment for tuberculosis (TB), it is still a global health problem. In 2016, globally, 1.7 million people died of TB, 95% from resource-poor countries. This study aimed to estimate changing trends in all-cause mortality rate and identify features associated with mortality among suspected TB patients on treatment. Methods A cohort study of patients registered in a TB surveillance system from 2012 to 2016 and f...
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#1Martha MwangomeH-Index: 11
#2Moses NgariH-Index: 9
Last.James A. BerkleyH-Index: 41
view all 7 authors...
The World Health Organization currently defines severe acute malnutrition (SAM) in infants aged under 6 months of age using weight-for-length Z score (WLZ). Given widespread use of mid-upper arm circumference (MUAC) for identifying SAM in older children and weight-for-age (WAZ) for growth monitoring, there is increasing debate about the optimal anthropometric criteria to best identify infants u6m at-risk of mortality. To determine the discriminatory value for mortality during the first 12 months...
1 CitationsSource
#1Moses Ngari (Wellcome Trust)H-Index: 9
#2Per Ole IversenH-Index: 34
Last.James A. BerkleyH-Index: 41
view all 7 authors...
Background Stunting is the most common manifestation of childhood undernutrition worldwide. Children presenting with severe acute malnutrition (SAM) are often also severely stunted. We evaluated linear growth and its determinants after medically complicated SAM. Methods We performed secondary analysis of clinical trial data ( NCT00934492) from HIV-uninfected Kenyan children aged 2–59 months hospitalised with SAM. Outcome was change in height/length-for-age z-score (HAZ) between enrolment and 12 ...
1 CitationsSource
#2Wieger P. Voskuijl (UNIMA: University of Malawi)H-Index: 14
Last.James A. BerkleyH-Index: 41
view all 24 authors...
Background Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality and delayed recovery. We tested the hypothesis that a lactose-free, low-carbohydrate F75 milk would serve to limit these risks, thereby reducing the number of days in the stabilization phase. Methods and findings In a multicenter double-blind trial, hospitalized severely malnourished ch...
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#1Meseret Molla (AAU: Addis Ababa University)H-Index: 2
#2Henok Negussie (BSMS: Brighton and Sussex Medical School)H-Index: 3
Last.Gail Davey (AAU: Addis Ababa University)H-Index: 37
view all 8 authors...
We use the example of the Gojjam Lymphoedema Best Practice Trial (GoLBeT), a pragmatic trial in a remote rural setting in northern Ethiopia, to extract lessons relevant to other investigators balancing the demands of practicality and community acceptability with internal and external validity in clinical trials. We explain in detail the preparation for the trial, its setting in northern Ethiopia, the identification and selection of patients (inclusion and exclusion criterion, identifying and scr...
2 CitationsSource
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