Ekram Nemr Abd Al Haleem
Al-Azhar University
Publications 10
AbstractObjectives: The current research seeks to assess the anti-atherogenic activity of Egyptian artichoke leaf extract in hypercholesterolemic rats.Materials and methods: Male albino rats were c...
#1Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
#2Wesam M. El-Bakly (Ain Shams University)H-Index: 9
Abstract Background MAP kinases, CREB, and Tau are signaling molecules among downstream synaptic targets involved in synaptic function, memory formation and cognition. Purpose Here we investigate the neuro-protective effect of selenium in HFHCD induced tauopathy and cognitive impairment in rats. The study was focused on the effects on synaptic plasticity related molecules in hippocampus, which in turn may be the mechanism responsible for underlying behavior alterations. Method Rats were divided ...
1 CitationsSource
#1Azza A. Ali (Al-Azhar University)H-Index: 6
#2Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
Last.Amany Said Sallam (Al-Azhar University)H-Index: 1
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Abstract Background Ulcerative colitis (UC) is an inflammatory bowel disease with significant morbidity. Cardamonin is a natural chalcone derivative with considerable anti-inflammatory activity. Herein, the potential protective effect of cardamonin against UC was tested in a rat model. Methods Rats were given 10 or 30 mg/kg/day of cardamonin orally for 14 days before induction of UC. On the 14th day of treatment, UC was induced by intrarectal instillation of 2 ml 3% acetic acid. Twenty four h af...
9 CitationsSource
#2Dina Sabry (Cairo University)H-Index: 20
Last.Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
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AbstractIntroduction: Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases. This study aimed to investigate and compare the therapeutic efficacy of different magnesium (Mg)-containing supplements (formulations A, B, and C) on carbon tetrachloride (CCl4)-induced liver fibrosis in rats. Methods: Liver fibrosis was induced by intraperitoneal injection of rats with CCl4 (1:1 in olive oil, 2 mL/kg, t...
2 CitationsSource
#1Aya MohammedH-Index: 1
Last.Ebtehal El-Demerdash (Misr International University)H-Index: 20
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7 CitationsSource
#1Azza S. Awad (Al-Azhar University)H-Index: 11
#2Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
Last.Mohie A. Sherief (Banha University)H-Index: 1
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Nonalcoholic steatohepatitis (NAFLD) is a progressive form of liver disease that leads to advanced fibrosis. The present study was designed to assess the hepatoprotective effect of thymoquinone (TQ) on liver functions, insulin resistance, and PPAR-γ expression in NAFLD. Rats were divided into two main groups: one fed with normal rat chow diet and the other with high-fat high-cholesterol diet group for 6 weeks. Every group was subdivided into three subgroups (n = 8): treated with saline, low dose...
17 CitationsSource
#1Aya Galal (Ain Shams University)H-Index: 1
#2Wesam M. El-Bakly (Ain Shams University)H-Index: 9
Last.Ebtehal El-Demerdash (Ain Shams University)H-Index: 20
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Purpose Doxorubicin (DOX) is an effective anticancer drug; however, its clinical use is limited by its cardiotoxic effect. Adenosine was proved to mediate anti-inflammatory effects and protected from myocardial ischemia/reperfusion injury. So the present work was designed to examine the effectiveness of a selective A3 adenosine receptor agonist (Cl-IB-MECA) in DOX-induced cardiotoxicity and to elucidate the underlying mechanisms via studying its effect on different oxidative stress, inflammatory...
3 CitationsSource
#1Reem N. El-Naga (Ain Shams University)H-Index: 7
#2Hebatalla I. Ahmed (Al-Azhar University)H-Index: 5
Last.Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
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Abstract The relationship between inflammation, oxidative stress and the incidence of depression had been well studied. Indole-3-carbinol (I3C), a natural active compound found in cruciferous vegetables, was shown to have anti-oxidant and anti-inflammatory activities. Therefore, the aim of this study was to investigate the potential protective effects of I3C against clonidine-induced depression-like behaviors in rats. Also, the possible mechanisms underlying this neuroprotection; anti-oxidant, a...
20 CitationsSource
Diabetes mellitus is the most common endocrine disorder that affects more than 285 million people worldwide. The purpose of this study was to investigate the effect of mesenchymal stem cells (MSCs) from the bone marrow of albino rats, on hyperglycemia, hyperlipidemia, and oxidative stress induced by intraperitoneal injection (i.p.) of alloxan at a dose of 150 mg/kg in rats. Injection of alloxan into rats resulted in a significant increase in serum glucose, total cholesterol, triglyceride, low de...
11 CitationsSource
#2Shaza Abdel-Halim Mohamed (Al-Azhar University)H-Index: 1
Last.Ekram Nemr Abd Al Haleem (Al-Azhar University)H-Index: 6
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Nephrotoxicity is defined as renal dysfunction that arises as result of exposure to external agents such as drugs and environmental chemicals. The present work was undertaken to carry out the phytochemical study and nephroprotective activity of methanolic extract of Casuarina equisetifolia leaves in gentamicin-induced nephrotoxicity in Wistar rats. Flavonoids and phenolic acids were identified and quantified using high performance liquid chromatography. Subcutaneous injection of rats with gentam...
10 CitationsSource