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Elise Dalmas
University of Basel
13Publications
7H-index
342Citations
Publications 13
Newest
Published on Feb 1, 2018in Cell Reports7.82
Marianne Böni-Schnetzler21
Estimated H-index: 21
(University of Basel),
Stéphanie P. Häuselmann5
Estimated H-index: 5
(University of Basel)
+ 10 AuthorsPraxedis Martin10
Estimated H-index: 10
Summary Interleukin-1 receptor antagonist (IL-1Ra) is elevated in the circulation during obesity and type 2 diabetes (T2D) but is decreased in islets from patients with T2D. The protective role of local IL-1Ra was investigated in pancreatic islet β cell (βIL-1Ra)-specific versus myeloid-cell (myeloIL-1Ra)-specific IL-1Ra knockout (KO) mice. Deletion of IL-1Ra in β cells, but not in myeloid cells, resulted in diminished islet IL-1Ra expression. Myeloid cells were not the main source of circulatin...
Published on Nov 1, 2017in Immunity21.52
Elise Dalmas7
Estimated H-index: 7
(University of Basel),
Frank M. Lehmann2
Estimated H-index: 2
(University of Basel)
+ 18 AuthorsDianne H. Dapito2
Estimated H-index: 2
(ETH Zurich)
Summary Pancreatic-islet inflammation contributes to the failure of β cell insulin secretion during obesity and type 2 diabetes. However, little is known about the nature and function of resident immune cells in this context or in homeostasis. Here we show that interleukin (IL)-33 was produced by islet mesenchymal cells and enhanced by a diabetes milieu (glucose, IL-1β, and palmitate). IL-33 promoted β cell function through islet-resident group 2 innate lymphoid cells (ILC2s) that elicited retin...
Published on Mar 1, 2017in Nature Immunology23.53
Erez Dror7
Estimated H-index: 7
,
Elise Dalmas7
Estimated H-index: 7
+ 17 AuthorsFriederike Schulze4
Estimated H-index: 4
The deleterious effect of chronic activation of the IL-1β system on type 2 diabetes and other metabolic diseases is well documented. However, a possible physiological role for IL-1β in glucose metabolism has remained unexplored. Here we found that feeding induced a physiological increase in the number of peritoneal macrophages that secreted IL-1β, in a glucose-dependent manner. Subsequently, IL-1β contributed to the postprandial stimulation of insulin secretion. Accordingly, lack of endogenous I...
Published on Mar 1, 2017in Cell Reports7.82
Shuyang Traub5
Estimated H-index: 5
(University of Basel),
Daniel T. Meier2
Estimated H-index: 2
(University of Basel)
+ 11 AuthorsValmir Makshana1
Estimated H-index: 1
(University of Basel)
Summary Pancreatic α cells may process proglucagon not only to glucagon but also to glucagon-like peptide-1 (GLP-1). However, the biological relevance of paracrine GLP-1 for β cell function remains unclear. We studied effects of locally derived insulin secretagogues on β cell function and glucose homeostasis using mice with α cell ablation and with α cell-specific GLP-1 deficiency. Normally, intestinal GLP-1 compensates for the lack of α cell-derived GLP-1. However, upon aging and metabolic stre...
Published on Jul 1, 2016in Gastroenterology19.23
Katharina Timper14
Estimated H-index: 14
(University of Basel),
Elise Dalmas7
Estimated H-index: 7
(University of Basel)
+ 9 AuthorsJulie Kerr-Conte39
Estimated H-index: 39
(university of lille)
Background & Aims Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and α cells, leading to secretion of insulin from β cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. Methods We obtained samples of human pancreatic islets and isolated islets from mice; human α cells and β cells were sorted by flow cytometry and incubated with GIP. Islets were analyze...
Published on Jan 1, 2016
Katharina Timper14
Estimated H-index: 14
,
Elise Dalmas7
Estimated H-index: 7
+ 9 AuthorsJulie Kerr-Conte39
Estimated H-index: 39
BACKGROUND & AIMS: Glucose-dependent insulinotropic peptide (GIP) induces production of interleukin 6 (IL6) by adipocytes. IL6 increases production of glucagon-like peptide (GLP)-1 by L cells and a cells, leading to secretion of insulin from b cells. We investigated whether GIP regulates GLP1 and glycemia via IL6. METHODS: We obtained samples of human pancreatic islets and isolated islets from mice; human a cells and b cells were sorted by flow cytometry and incubated with GIP. Islets were analy...
Published on Oct 1, 2015in Trends in Endocrinology and Metabolism9.78
Christian Herder62
Estimated H-index: 62
(HHU: University of Düsseldorf),
Elise Dalmas7
Estimated H-index: 7
+ 1 AuthorsMarc Y. Donath57
Estimated H-index: 57
Patients with type 2 diabetes (T2D) exhibit chronic activation of the innate immune system in pancreatic islets, in insulin-sensitive tissues, and at sites of diabetic complications. This results from a pathological response to overnutrition and physical inactivity seen in genetically predisposed individuals. Processes mediated by the proinflammatory cytokine interleukin-1 (IL-1) link obesity and dyslipidemia and have implicated IL-1β in T2D and related cardiovascular complications. Epidemiologi...
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