Siva Sundara Kumar Durairajan
Central University of Tamil Nadu
Publications 43
#1Ashok Iyaswamy (Hong Kong Baptist University)H-Index: 3
#2Senthil Kumar Krishnamoorthi (Hong Kong Baptist University)H-Index: 1
Last.Min Li (Hong Kong Baptist University)H-Index: 27
view all 15 authors...
Abstract Alzheimer's disease (AD) is the most common age-related neurodegenerative disorder. Amyloid-β (Aβ) and hyper-phosphorylated tau accumulation are accountable for the progressive neuronal loss and cognitive impairments usually observed in AD. Currently, medications for AD offer moderate symptomatic relief but fail to cure the disease; hence development of effective and safe drugs is urgently needed for AD treatment. In this study, we investigated a Chinese medicine (CM) formulation named ...
#1Chuanbin Yang (Hong Kong Baptist University)H-Index: 10
#2Cui-Zan Cai (UM: University of Macau)H-Index: 4
Last.Jia-Hong Lu (UM: University of Macau)H-Index: 19
view all 11 authors...
ABSTRACTAlzheimer disease (AD) is the most common neurodegenerative disease characterized by the deposition of amyloid plaque in the brain. The autophagy-associated PIK3C3-containing phosphatidylinositol 3-kinase (PtdIns3K) complex has been shown to interfere with APP metabolism and amyloid beta peptide (Aβ) homeostasis via poorly understood mechanisms. Here we report that NRBF2 (nuclear receptor binding factor 2), a key component and regulator of the PtdIns3K, is involved in APP-CTFs homeostasi...
10 CitationsSource
#1Siva Sundara Kumar Durairajan (Hong Kong Baptist University)H-Index: 15
#2Ashok Iyaswamy (Hong Kong Baptist University)H-Index: 3
Last.Min Li (Hong Kong Baptist University)H-Index: 5
view all 13 authors...
Alzheimer’s disease (AD) is a degenerative disorder typified by progressive deterioration of memory and the appearance of β-amyloid peptide (Aβ)-rich senile plaques. Recently we have identified a novel function of a patented formulation of modified Huanglian-Jie-Tu-Tang (HLJDT-M), a Chinese herbal medicine, in treating AD in in vitro studies (US patent No. 9,375,457). HLJDT-M is a formulation composed of Rhizoma Coptitis, Cortex Phellodendri and Fructus Gardeniae without Radix Scutellariae. Here...
3 CitationsSource
Abstract Generation and accumulation of the amyloid-β (Aβ) peptide after proteolytic processing of the full length amyloid precursor protein (FL-APP) by β-secretase (β-site APP cleaving enzyme or BACE1) and γ-secretase are the main causal factors of Alzheimer's disease (AD). Thus, inhibition of BACE1, a rate-limiting enzyme in the production of Aβ, is an attractive therapeutic approach for the treatment of AD. Recent studies suggest that salvianolic acid B (Sal B) is isolated from the radix of S...
6 CitationsSource
#2Rambabu ReddyH-Index: 1
Last.Min LiH-Index: 27
view all 8 authors...
1 CitationsSource
#1Ju-Xian Song (Hong Kong Baptist University)H-Index: 10
#2Yueru Sun (HKUST: Hong Kong University of Science and Technology)H-Index: 6
Last.Min Li (Hong Kong Baptist University)H-Index: 27
view all 20 authors...
Autophagy dysfunction is a common feature in neurodegenerative disorders characterized by accumulation of toxic protein aggregates. Increasing evidence has demonstrated that activation of TFEB (transcription factor EB), a master regulator of autophagy and lysosomal biogenesis, can ameliorate neurotoxicity and rescue neurodegeneration in animal models. Currently known TFEB activators are mainly inhibitors of MTOR (mechanistic target of rapamycin [serine/threonine kinase]), which, as a master regu...
33 CitationsSource
#1Liang-Feng LiuH-Index: 13
#2Ju-Xian SongH-Index: 10
Last.Min LiH-Index: 27
view all 9 authors...
Tianma Gouteng Yin, a Traditional Chinese Medicine decoction, exerts neuroprotective effects in animal and cellular models of Parkinson’s disease
13 CitationsSource
#1Ju-Xian SongH-Index: 10
#2Yu ZengH-Index: 2
Last.Min LiH-Index: 27
view all 10 authors...
#1Lei-Lei Chen (Hong Kong Baptist University)H-Index: 9
#2Ju-Xian Song (Hong Kong Baptist University)H-Index: 10
Last.Min Li (Hong Kong Baptist University)H-Index: 27
view all 7 authors...
Parkinson’s disease (PD) is the second most common neurodegenerative disorder characterized by the accumulation of protein aggregates (namely Lewy bodies) in dopaminergic neurons in the substantia nigra region of the brain. Alpha-synuclein (α-syn) is the major component of Lewy bodies in PD patients, and impairment of the autophagy-lysosomal system has been linked to its accumulation. In our previous study, we identified an oxindole alkaloid Corynoxine B (Cory B), isolated from Uncaria rhynchoph...
33 CitationsSource