Thomas A. Rando
Stanford University
Publications 193
#1Karina H. Nakayama (Cardiovascular Institute of the South)H-Index: 9
#2Marco Quarta (Stanford University)H-Index: 11
Last.Thomas A. Rando (Stanford University)H-Index: 68
view all 11 authors...
Traumatic skeletal muscle injuries cause irreversible tissue damage and impaired revascularization. Engineered muscle is promising for enhancing tissue revascularization and regeneration in injured muscle. Here we fabricated engineered skeletal muscle composed of myotubes interspersed with vascular endothelial cells using spatially patterned scaffolds that induce aligned cellular organization, and then assessed their therapeutic benefit for treatment of murine volumetric muscle loss. Murine skel...
#1Zurine De Miguel (Stanford University)H-Index: 4
#2Michael J. Betley (Stanford University)
Last.Thomas A. Rando (Stanford University)H-Index: 68
view all 11 authors...
Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects. We discovered 9runner9 plasma, collected from voluntarily running mice, infused into sedentary mice recapitulates the cellular and functional benefits of exercise on the brain. Importantly, runner pl...
#1Vivianne L. Tawfik (Stanford University)H-Index: 16
#2Marco Quarta (Stanford University)H-Index: 11
Last.J. David Clark (Stanford University)H-Index: 51
view all 9 authors...
Chronic pain and disability after limb injury are major public health problems. One key obstacle to addressing these adverse outcomes is that we do not know when exercise should be initiated or whether the beneficial effects of exercise can be reproduced using pharmacological tools. In these studies, we developed and used a murine model of orthopaedic trauma combining tibia fracture and pin fixation with tibialis anterior muscle damage. Behavioral measures included mechanical nociceptive thresho...
#1Huibin Tang (Stanford University)H-Index: 11
#2Ken Inoki (UM: University of Michigan)H-Index: 46
Last.Xuhuai Ji (Stanford University)
view all 21 authors...
#1Michael N. Wosczyna (Stanford University)H-Index: 5
#2Colin T. Konishi (Stanford University)
Last.Thomas A. Rando (Stanford University)H-Index: 68
view all 8 authors...
Summary The necessity of mesenchymal stromal cells, called fibroadipogenic progenitors (FAPs), in skeletal muscle regeneration and maintenance remains unestablished. We report the generation of a PDGFRα CreER knockin mouse model that provides a specific means of labeling and targeting FAPs. Depletion of FAPs using Cre-dependent diphtheria toxin expression results in loss of expansion of muscle stem cells (MuSCs) and CD45+ hematopoietic cells after injury and impaired skeletal muscle regeneration...
#1Tapash Jay Sarkar (Stanford University)
#2Marco QuartaH-Index: 11
Last.BhutaniNidhi (Stanford University)H-Index: 15
view all 12 authors...
Summary Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels 1-3 . At the chromatin level, aging is associated with the progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis 3 . The technology of nuclear reprogramming to pluripotency, through over-expression of a small number of transcription factors, can revert bot...
#1Arti Hurria (City of Hope National Medical Center)H-Index: 48
#2Chris Carpenter (WashU: Washington University in St. Louis)H-Index: 29
Last.Joachim H. Ix (UCSD: University of California, San Diego)H-Index: 54
view all 19 authors...
#1Cindy T.J. van Velthoven (Stanford University)H-Index: 5
#2Thomas A. Rando (Stanford University)H-Index: 68
Summary Stem cells can reside in a state of reversible growth arrest, or quiescence, for prolonged periods of time. Although quiescence has long been viewed as a dormant, low-activity state, increasing evidence suggests that quiescence represents states of poised potential and active restraint, as stem cells "idle" in anticipation of activation, proliferation, and differentiation. Improved understanding of quiescent stem cell dynamics is leading to novel approaches to enhance maintenance and rep...
#1Karina H. Nakayama (Cardiovascular Institute of the South)H-Index: 9
#2Cynthia AlcazarH-Index: 3
Last.Ngan F. Huang (Cardiovascular Institute of the South)H-Index: 29
view all 9 authors...
Muscle regeneration can be permanently impaired by traumatic injuries, despite the high regenerative capacity of skeletal muscle. Implantation of engineered biomimetic scaffolds to the site of muscle ablation may serve as an attractive off-the-shelf therapeutic approach. The objective of the study was to histologically assess the therapeutic benefit of a three-dimensional spatially patterned collagen scaffold, in conjunction with rehabilitative exercise, for treatment of volumetric muscle loss. ...