Thomas A. Rando
Stanford University
Molecular biologySkeletal muscleStem cellBiologyCell biology
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Publications 201
#1Jamie O. Brett (Stanford University)H-Index: 6
#2Marina Arjona (Stanford University)H-Index: 1
Last. Daniel I. Benjamin (Stanford University)H-Index: 1
view all 15 authors...
Ageing impairs tissue repair. This defect is pronounced in skeletal muscle, whose regeneration by muscle stem cells (MuSCs) is robust in young-adult animals, but inefficient in older organisms. Despite this functional decline, old MuSCs are amenable to rejuvenation through strategies that improve the systemic milieu, such as heterochronic parabiosis. One such strategy, exercise, has long been appreciated for its benefits on healthspan, but its effects on aged stem-cell function in the context of...
1 CitationsSource
#1Tapash Jay Sarkar (Stanford University)
#2Marco QuartaH-Index: 12
Last. Lei S. Qi (Stanford University)H-Index: 30
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Aging is characterized by a gradual loss of function occurring at the molecular, cellular, tissue and organismal levels. At the chromatin level, aging associates with progressive accumulation of epigenetic errors that eventually lead to aberrant gene regulation, stem cell exhaustion, senescence, and deregulated cell/tissue homeostasis. Nuclear reprogramming to pluripotency can revert both the age and the identity of any cell to that of an embryonic cell. Recent evidence shows that transient repr...
1 CitationsSource
#1Nick J. Willett (Emory University)H-Index: 14
#2Michael L. Boninger (University of Pittsburgh)H-Index: 54
Last. Christopher L. Dearth (USU: Uniformed Services University of the Health Sciences)H-Index: 2
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Abstract The growing field of Regenerative Rehabilitation has great potential to improve clinical outcomes for individuals with disabilities. However, the science to elucidate the specific biological underpinnings of Regenerative Rehabilitation-based approaches is still in its infancy and critical questions regarding clinical translation and implementation still exist. In a recent roundtable discussion from International Consortium for Regenerative Rehabilitation (ICRR) stakeholders, key challen...
1 CitationsSource
#1Jennifer CableH-Index: 1
#2Elaine Fuchs (Rockefeller University)H-Index: 134
Last. Mark A. Krasnow (Stanford University)H-Index: 52
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Adult stem cells are rare, undifferentiated cells found in all tissues of the body. Although normally kept in a quiescent, nondividing state, these cells can proliferate and differentiate to replace naturally dying cells within their tissue and to repair its wounds in response to injury. Due to their proliferative nature and ability to regenerate tissue, adult stem cells have the potential to treat a variety of degenerative diseases as well as aging. In addition, since stem cells are often thoug...
#1Vivianne L. Tawfik (Stanford University)H-Index: 16
#2Marco Quarta (Stanford University)H-Index: 12
Last. J. David Clark (Stanford University)H-Index: 52
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KEY POINTS: Our tibial fracture orthopaedic injury model in mice recapitulates the major manifestations of complex trauma, including nociceptive sensitization, bone fracture, muscle fibrosis and muscle fibre loss. Delayed exercise after complex orthopaedic trauma results in decreased muscle fibrosis and improved pain Losartan, an angiotensin-receptor blocker with anti-fibrotic abilities, recapitulates the effect of exercise on post-injury recovery and may provide an enhanced recovery option for ...
1 CitationsSource
#1David FurmanH-Index: 21
#2Judith Campisi (LBNL: Lawrence Berkeley National Laboratory)H-Index: 89
Last. George M. Slavich (UCLA: University of California, Los Angeles)H-Index: 28
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Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and aut...
25 CitationsSource
#1Antoine de Morrée (Stanford University)H-Index: 11
#2Julian D. D. Klein (Stanford University)H-Index: 1
Last. Thomas A. Rando (Stanford University)H-Index: 70
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Adult stem cells are essential for tissue homeostasis. In skeletal muscle, muscle stem cells (MuSCs) reside in a quiescent state, but little is known about the mechanisms that control homeostatic turnover. Here we show that, in mice, the variation in MuSC activation rate among different muscles (for example, limb versus diaphragm muscles) is determined by the levels of the transcription factor Pax3. We further show that Pax3 levels are controlled by alternative polyadenylation of its transcript,...
3 CitationsSource
#1Zurine De Miguel (Stanford University)H-Index: 4
#2Michael J. Betley (Stanford University)H-Index: 1
Last. Tony Wyss-CorayH-Index: 66
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Physical exercise seems universally beneficial to human and animal health, slowing cognitive aging and neurodegeneration. Cognitive benefits are tied to increased plasticity and reduced inflammation within the hippocampus, yet little is known about the factors and mechanisms mediating these effects. We discovered 9runner9 plasma, collected from voluntarily running mice, infused into sedentary mice recapitulates the cellular and functional benefits of exercise on the brain. Importantly, runner pl...
1 CitationsSource
#1Vivianne L. Tawfik (Stanford University)H-Index: 16
#2Marco Quarta (Stanford University)H-Index: 12
Last. J. David Clark (Stanford University)H-Index: 52
view all 9 authors...
Chronic pain and disability after limb injury are major public health problems. One key obstacle to addressing these adverse outcomes is that we do not know when exercise should be initiated or whether the beneficial effects of exercise can be reproduced using pharmacological tools. In these studies, we developed and used a murine model of orthopaedic trauma combining tibia fracture and pin fixation with tibialis anterior muscle damage. Behavioral measures included mechanical nociceptive thresho...
#1Huibin Tang (Stanford University)H-Index: 11
#2Ken Inoki (UM: University of Michigan)H-Index: 47
Last. Joseph B. Shrager (Stanford University)H-Index: 44
view all 21 authors...
4 CitationsSource