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G.J. van der Wilt
Radboud University Nijmegen
SurgeryHealth carePhysical therapyHealth technologyMedicine
250Publications
36H-index
5,182Citations
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Publications 220
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#1Janneke P.C. Grutters (Radboud University Nijmegen)H-Index: 24
#2Tim M. GoversH-Index: 6
Last. Maroeska M. RoversH-Index: 41
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#1Tamara van Woezik (Radboud University Nijmegen)H-Index: 1
#2Jur Koksma (Radboud University Nijmegen)H-Index: 1
Last. G.J. van der Wilt (Radboud University Nijmegen)H-Index: 36
view all 5 authors...
AbstractTo foster lifelong learning skills, we need new didactic approaches with aligned assessment methods. Therefore, we investigated whether the outcomes of a project assignment show a different...
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#1Bas C. Stunnenberg (Radboud University Nijmegen)H-Index: 6
#2Jaap Deinum (Radboud University Nijmegen)H-Index: 30
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N-of-1 trials can provide high-class evidence on drug treatment effectiveness at the individual patient level and have been given renewed interest over the past decade due to improvements of the initial single patient design. Despite these recent developments, there is still no consensus under what circumstances N-of-1 trials should be considered as part of evidence-based clinical care and when they represent medical research with need for institutional review board (IRB) approval. This lack of ...
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#1Wouter J. Rijke (Radboud University Nijmegen)H-Index: 1
#1Wouter J. Rijke (Radboud University Nijmegen)
Last. G.J. van der Wilt (Radboud University Nijmegen)H-Index: 36
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AbstractIntroduction: The main idea underlying this paper is that impairments such as deafness are particularly relevant to the extent that they lead to deprivation of capability. Likewise, the imp...
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#1Anouck Kluytmans (Radboud University Nijmegen)H-Index: 5
#2Jaap Deinum (Radboud University Nijmegen)H-Index: 30
Last. Janneke P.C. Grutters (Radboud University Nijmegen)H-Index: 24
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: Background Choosing which biomarker tests to select for further research and development is not only a matter of diagnostic accuracy, but also of the clinical and monetary benefits downstream. Early health economic modeling provides tools to assess the potential effects of biomarker innovation and support decision-making. Methods We applied early health economic modeling to the case of diagnosing primary aldosteronism in patients with resistant hypertension. We simulated a cohort of patients u...
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#1J. Deinum (TUD: Dresden University of Technology)H-Index: 1
#2H. GroenewoudH-Index: 5
Last. Gian Paolo RossiH-Index: 54
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: Notwithstanding the high prevalence of primary aldosteronism (PA), probably the most common form of secondary hypertension, the diagnosis of PA is often neglected, or delayed, thus precluding target treatment, which is curative in many cases. For selection of the most appropriate treatment a fundamental step is the distinction between a lateralized form, mainly aldosterone-producing adenoma (APA), and bilateral adrenocortical hyperplasia (BAH), also known as idiopathic hyperaldosteronism (IHA)...
1 CitationsSource
#1Janette Rahamat-Langendoen (Radboud University Nijmegen)H-Index: 12
#2H. Groenewoud (Radboud University Nijmegen)H-Index: 5
Last. G.J. van der Wilt (Radboud University Nijmegen)H-Index: 36
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BACKGROUND: At hospital admission, patients suspected of infection with influenza or respiratory syncytial virus (RSV) are placed in isolation, pending the outcome of diagnostics. In a significant number, isolated care proves unnecessary. We investigated the potential impact of molecular point-of-care (POC) diagnostics on patient management and in-hospital costs. METHOD: Prospective collection of data on resource utilization within the hospital from consecutive patients 18 years or older present...
1 CitationsSource
#1Rene Sluiter (Radboud University Nijmegen)H-Index: 1
#2C.J. van Marrewijk (Radboud University Nijmegen)H-Index: 11
Last. Marieke J.H. Coenen (Radboud University Nijmegen)H-Index: 39
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BACKGROUND AND AIMS: Decreased thiopurine S-methyltransferase [TPMT] enzyme activity increases the risk of haematological adverse drug reactions [ADRs] in patients treated with thiopurines. Clinical studies have shown that in patients with inflammatory bowel disease [IBD], pharmacogenetic TPMT-guided thiopurine treatment reduces this risk of ADRs. The aim of this study was to investigate whether this intervention impacts on healthcare costs and/or quality of life. METHODS: An a priori defined co...
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BACKGROUND: To assess whether early health economic modeling helps to distinguish those healthcare innovations that are potentially cost-effective from those that are not potentially cost-effective. We will also study what information is retrieved from the health economic models to inform further development, research and implementation decisions. METHODS: We performed secondary analyses on an existing database of 32 health economic modeling assessments of 30 innovations, performed by our group....
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#1Anouck Kluytmans (Radboud University Nijmegen)H-Index: 5
#2Marcia Tummers (Radboud University Nijmegen)H-Index: 12
Last. Janneke P.C. Grutters (Radboud University Nijmegen)H-Index: 24
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Abstract Background Although the relevance of both push and pull factors is acknowledged in models of innovation, needs, broadly defined, are rarely considered, whereas supply-driven innovation in publicly funded health systems carries the risk that it may not match the underlying problems experienced by patients and consumers. Objectives To explore a mixed-methods, multistakeholder approach that focuses on pertinent problems when assessing the potential value of an innovation as applied to a ca...
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