Baptiste Couvy-Duchesne
University of Queensland
PsychiatryPsychologyMajor depressive disorderClinical psychologySchizophrenia
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Publications 66
#1Laura Han (VU: VU University Amsterdam)H-Index: 3
#2Richard Dinga (Radboud University Nijmegen)H-Index: 2
Last. Klaus Berger (WWU: University of Münster)H-Index: 70
view all 146 authors...
Major depressive disorder (MDD) is associated with an increased risk of brain atrophy, aging-related diseases, and mortality. We examined potential advanced brain aging in adult MDD patients, and whether this process is associated with clinical characteristics in a large multicenter international dataset. We performed a mega-analysis by pooling brain measures derived from T1-weighted MRI scans from 19 samples worldwide. Healthy brain aging was estimated by predicting chronological age (18–75 yea...
#1Liza van Eijk (UQ: University of Queensland)H-Index: 3
#2Narelle K. Hansell (UQ: University of Queensland)H-Index: 37
Last. Margaret J. Wright (UQ: University of Queensland)H-Index: 66
view all 9 authors...
The hippocampus is a brain region critical for learning and memory, and is also implicated in several neuropsychiatric disorders that show sex differences in prevalence, symptom expression, and mean age of onset. On average, males have larger hippocampal volumes than females, but findings are inconclusive after adjusting for overall brain size. Although the hippocampus is a heterogenous structure, few studies have focused on sex differences in the hippocampal subfields - with little consensus on...
#1Baptiste Couvy-Duchesne (UQ: University of Queensland)H-Index: 11
#2Futao Zhang (UQ: University of Queensland)H-Index: 12
Last. Jian Yang (WMU: Wenzhou Medical College)H-Index: 113
view all 8 authors...
We evaluated the statistical power, family wise error rate (FWER) and precision of several competing methods that perform mass-univariate vertex-wise analyses of grey-matter (thickness and surface area). In particular, we compared several generalised linear models (GLMs, current state of the art) to linear mixed models (LMMs) that have proven superior in genomics. We used phenotypes simulated from real vertex-wise data and a large sample size (N=8,662) which may soon become the norm in neuroimag...
#1Katrina L. Grasby (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 7
#2Neda Jahanshad (SC: University of Southern California)H-Index: 42
Last. Mary Agnes B. McMahon (SC: University of Southern California)H-Index: 1
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INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with hu...
7 CitationsSource
#1Azmeraw T. Amare (University of Adelaide)H-Index: 40
#3Klaus Oliver Schubert (University of Adelaide)H-Index: 9
Last. Fasil Tekola-Ayele (NIH: National Institutes of Health)H-Index: 13
view all 296 authors...
Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtain...
#1Jan Scott (Newcastle University)H-Index: 1
#2Nicholas G. Martin (QIMR: QIMR Berghofer Medical Research Institute)H-Index: 157
Last. Ian B. Hickie (USYD: University of Sydney)H-Index: 82
view all 6 authors...
Aim: Subthreshold syndromes (STS) frequently precede the onset of full-threshold syndromes (FTS) of the corresponding mental disorder (homotypic continuity). This study examines whether subthreshold conditions are comorbid and whether there is heterotypic continuity also between STS and FTS. Methods: Data were extracted from the Brisbane “19Up” cohort study of twins and siblings (N = 1838; 56% female) on individuals who (i) completed self-report ratings of depression-like (DLE), hypomanic-like (...
#1Kenneth S. KendlerH-Index: 161
#2Charles O. GardnerH-Index: 34
Last. Nathan A. GillespieH-Index: 32
view all 10 authors...
4 CitationsSource
#1Lianne SchmaalH-Index: 22
#2Elena PozziH-Index: 2
Last. Dick J. VeltmanH-Index: 69
view all 76 authors...
#1Laura S. van Velzen (University of Melbourne)H-Index: 8
#2Sinead Kelly (Brigham and Women's Hospital)H-Index: 14
Last. Lianne Schmaal (University of Melbourne)H-Index: 22
view all 71 authors...
Alterations in white matter (WM) microstructure have been implicated in the pathophysiology of major depressive disorder (MDD). However, previous findings have been inconsistent, partially due to low statistical power and the heterogeneity of depression. In the largest multi-site study to date, we examined WM anisotropy and diffusivity in 1305 MDD patients and 1602 healthy controls (age range 12–88 years) from 20 samples worldwide, which included both adults and adolescents, within the MDD Worki...
3 CitationsSource