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Simona-Adriana Manea
Romanian Academy
EndocrinologyOxidative stressNADPH oxidaseMedicineCell biology
24Publications
8H-index
229Citations
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Publications 34
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#1Simona-Adriana Manea (Romanian Academy)H-Index: 8
#2M.L. Vlad (Romanian Academy)H-Index: 2
Last. Adrian Manea (Romanian Academy)H-Index: 20
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Abstract NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression in experimental models of cardiovascular disorders. Hitherto, the relation between HDAC and Nox in atherosclerosis is not known. We aimed at uncovering whether HDAC plays a role in mediating Nox up-regulation, oxidative stress, inflam...
2 CitationsSource
#1M.L. Vlad (Romanian Academy)H-Index: 2
#2Simona-Adriana Manea (Romanian Academy)H-Index: 8
Last. Adrian Manea (Romanian Academy)H-Index: 20
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Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regulation are not entirely elucidated. The aim of this study was to investigate the expression pattern of key histone acetyltransferase subtypes (p300, HAT1) in human atherosclerosis and to determine their role in mediating the upregulation of Nox5 in macrophages un...
3 CitationsSource
#1M.L. VladH-Index: 2
#3Monica RaicuH-Index: 15
Last. Simona-Adriana ManeaH-Index: 8
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#2M.L. VladH-Index: 2
#3A.G. LazarH-Index: 2
Last. Simona-Adriana ManeaH-Index: 8
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#3M.L. VladH-Index: 2
Last. Maya SimionescuH-Index: 43
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Objective:Dysregulated histone acetyltransferase (HDAC)-dependent epigenetic mechanisms have been increasingly linked to the pathoetiology of atherosclerosis, namely inflammation and oxidative stress. Experimental results in mice suggest that pharmacological inhibitors of HDAC might be novel therape
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#3Daniela StanH-Index: 13
Last. Simona-Adriana ManeaH-Index: 8
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Last. Maya SimionescuH-Index: 43
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#1Simona-Adriana Manea (Romanian Academy)H-Index: 8
#2Mihaela-Loredana Antonescu (Romanian Academy)H-Index: 1
Last. Adrian Manea (Romanian Academy)H-Index: 20
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Abstract Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene expression in cardiovascular disorders. Since their role in diabetes is still elusive we hypothesized that histone deacetylase (HDAC)-dependent mechanisms could mediate vascular Nox overexpression in diabetic conditions. Non-diabetic and str...
20 CitationsSource
Last. Maya SimionescuH-Index: 43
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1 CitationsSource
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