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Simona-Adriana Manea
Romanian Academy
73Publications
19H-index
1,256Citations
Publications 51
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#1Simona-Adriana Manea (Romanian Academy)H-Index: 19
#2M.L. Vlad (Romanian Academy)H-Index: 1
Last.Maya Simionescu (Romanian Academy)H-Index: 42
view all 8 authors...
Abstract NADPH oxidase (Nox)-derived reactive oxygen species (ROS) are instrumental in all inflammatory phases of atherosclerosis. Dysregulated histone deacetylase (HDAC)-related epigenetic pathways have been mechanistically linked to alterations in gene expression in experimental models of cardiovascular disorders. Hitherto, the relation between HDAC and Nox in atherosclerosis is not known. We aimed at uncovering whether HDAC plays a role in mediating Nox up-regulation, oxidative stress, inflam...
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#1Alina HanfH-Index: 4
#2Matthias OelzeH-Index: 32
Last.Andreas DaiberH-Index: 57
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Abstract The anthracycline doxorubicin (DOX) is widely used in cancer therapy with the limitation of cardiotoxicity leading to the development of congestive heart failure. DOX-induced oxidative stress and changes of the phosphoproteome as well as epigenome were described but the exact mechanisms of the adverse long-term effects are still elusive. Here, we tested the impact of DOX treatment on cell death, oxidative stress parameters and expression profiles of proteins involved in epigenetic pathw...
1 CitationsSource
#1M.L. Vlad (Romanian Academy)H-Index: 1
#2Simona-Adriana Manea (Romanian Academy)H-Index: 19
Last.Maya Simionescu (Romanian Academy)H-Index: 42
view all 7 authors...
Histone acetylation plays a major role in epigenetic regulation of gene expression. Monocyte-derived macrophages express functional NADPH oxidase 5 (Nox5) that contributes to oxidative stress in atherogenesis. The mechanisms of Nox5 regulation are not entirely elucidated. The aim of this study was to investigate the expression pattern of key histone acetyltransferase subtypes (p300, HAT1) in human atherosclerosis and to determine their role in mediating the upregulation of Nox5 in macrophages un...
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#1M.L. VladH-Index: 1
Last.Maya SimionescuH-Index: 42
view all 6 authors...
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#2M.L. VladH-Index: 1
Last.Maya SimionescuH-Index: 42
view all 6 authors...
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#2Daniela StanH-Index: 13
Last.Simona-Adriana ManeaH-Index: 19
view all 6 authors...
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Last.Maya SimionescuH-Index: 42
view all 7 authors...
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#1Simona-Adriana Manea (Romanian Academy)H-Index: 19
#2Mihaela-Loredana Antonescu (Romanian Academy)H-Index: 1
Last.Maya Simionescu (Romanian Academy)H-Index: 42
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Abstract Reactive oxygen species (ROS) generated by up-regulated NADPH oxidase (Nox) contribute to structural-functional alterations of the vascular wall in diabetes. Epigenetic mechanisms, such as histone acetylation, emerged as important regulators of gene expression in cardiovascular disorders. Since their role in diabetes is still elusive we hypothesized that histone deacetylase (HDAC)-dependent mechanisms could mediate vascular Nox overexpression in diabetic conditions. Non-diabetic and str...
13 CitationsSource
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