Match!
Hannu Koistinen
University of Helsinki
EndocrinologyMolecular biologyGlycodelinBiochemistryBiology
153Publications
35H-index
3,482Citations
What is this?
Publications 159
Newest
#1Laura Hautala (UH: University of Helsinki)H-Index: 8
#2Poh-Choo Pang (Imperial College London)H-Index: 14
Last. Stuart M. Haslam (Imperial College London)H-Index: 10
view all 12 authors...
Glycodelin is a major glycoprotein expressed in reproductive tissues, like secretory and decidualized endometrium. It has several reproduction related functions that are dependent on specific glycosylation, but it has also been found to drive differentiation of endometrial carcinoma cells toward a less malignant phenotype. Here we aimed to elucidate whether the glycosylation and function of glycodelin is altered in endometrial carcinoma as compared with a normal endometrium. We carried out glyca...
Source
#1Hannu KoistinenH-Index: 35
#2Ulf-Hakan StenmanH-Index: 1
Abstract Human chorionic gonadotropin (hCG) is a heterodimer consisting of an α- and a β-subunit (hCGα and hCGβ) that are noncovalently linked. The α-subunit is identical to those in other glycoprotein hormones, i.e., LH, FSH, and TSH. While intact hCG heterodimer binds to the LH/hCG receptor (LHCGR) in the corpus luteum, stimulating progesterone production essential for successful pregnancy the free β-subunit does not activate the LHCGR. However, free hCGβ is present in several tissues, includi...
Source
#1Madhavi Vijayan (HKU: University of Hong Kong)H-Index: 2
#2Cheuk-Lun Lee (HKU: University of Hong Kong)H-Index: 16
Last. William S.B. Yeung (HKU: University of Hong Kong)H-Index: 42
view all 12 authors...
Decidual macrophages constitute 20–30% of the total leukocytes in the pregnant uterus, which regulates maternal immune tolerance and placenta development. Abnormal number or activities of decidual macrophages are associated with fetal loss and pregnancy complications such as preeclampsia. Monocytes differentiate into decidual macrophages in a decidua-specific microenvironment. Despite their important roles in pregnancy, the factors regulating the differentiation of decidual macrophages remain un...
Source
#2Thomas KryzaH-Index: 5
Last. Jyotsna BatraH-Index: 26
view all 20 authors...
Source
#1Sawan Kumar Jha (UH: University of Helsinki)H-Index: 7
#2Khushbu Rauniyar (UH: University of Helsinki)H-Index: 2
Last. Michael Jeltsch (UH: University of Helsinki)H-Index: 36
view all 9 authors...
The lymphatic system is composed of networks of vessels that drain fluids from the body’s tissues and filter it back into the blood. Growing these vessels depends on a factor known as VEGF-C, which is released in an inactive form and must be cut by enzymes before it can work. One enzyme that is known to activate the VEGF-C signal when the early embryo is developing is ADAMTS3. If this signal fails to switch on this can result in a condition known as lymphedema – whereby problems in the lymphatic...
1 CitationsSource
#1Sawan Kumar Jha (UH: University of Helsinki)H-Index: 7
#2Khushbu Rauniyar (UH: University of Helsinki)H-Index: 2
Last. Michael Jeltsch (UH: University of Helsinki)H-Index: 36
view all 9 authors...
Source
#1Jennifer J. Adibi (University of Pittsburgh)H-Index: 10
#2Xiaoshuang Xun (University of Pittsburgh)
Last. Ulf-Håkan Stenman (UH: University of Helsinki)H-Index: 72
view all 10 authors...
Source
#1Cheuk-Lun Lee (HKU: University of Hong Kong)H-Index: 16
#2Madhavi Vijayan (HKU: University of Hong Kong)H-Index: 2
Last. Philip C.N. Chiu (HKU: University of Hong Kong)H-Index: 26
view all 10 authors...
1 CitationsSource
#1Hannu Koistinen (UH: University of Helsinki)H-Index: 35
#2Mariann Koel (UT: University of Tartu)H-Index: 4
Last. Darja Lavogina (UT: University of Tartu)H-Index: 10
view all 11 authors...
Abstract While human chorionic gonadotropin (hCG) appears to have an essential role in early pregnancy, it is controversial whether the hyperglycosylated form of hCG (hCG-h), which is the major hCG isoform during the first 4–5 weeks of pregnancy, is able to activate LH/hCG receptor (LHCGR). To address this, we utilized different extensively characterized hCG and hCGβ reference reagents, cell culture- and urine-derived hCG-h preparations, and an in vitro reporter system for LHCGR activation. The ...
Source
#1Srilakshmi Srinivasan (QUT: Queensland University of Technology)H-Index: 9
#2Carson R. Stephens (QUT: Queensland University of Technology)H-Index: 7
Last. Jyotsna Batra (QUT: Queensland University of Technology)H-Index: 26
view all 13 authors...
BACKGROUND: Genetic association studies have reported single-nucleotide polymorphisms (SNPs) at chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 ( KLK3 ) gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk ( P = 2.3 × 10 −8 ). However, the biological contribution of the rs61752561 SNP to PCa risk has not been elucidated. METHODS: ...
3 CitationsSource
12345678910