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Demosthenes E Ziogas
University of Ioannina
30Publications
5H-index
65Citations
Publications 30
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Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise d...
3 CitationsSource
Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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6 CitationsSource
Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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1 CitationsSource
Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Despite standardization of multimodal treatment and approval of several targeted drugs for resectable, non-metastatic cancer (M0 patients), intrinsic and acquired resistance and relapse rates remain high, even in early-stage aggressive tumors. Genome analysis could overcome these unmet needs. Our comprehensive review underlines the controversy on stable or spatiotemporally evolving clones as well as promising yet inconclusive data on genome-based biomarkers and drug development. We propose clini...
7 CitationsSource
Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last.Dimitrios H Roukos (Academy of Athens)H-Index: 4
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1 CitationsSource
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