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Demosthenes E Ziogas
University of Ioannina
GenomeDNA sequencingBreast cancerBioinformaticsMedicine
30Publications
5H-index
65Citations
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Publications 31
Newest
Last. Dimitrios H RoukosH-Index: 62
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The increasing incidence combined with constant rates of early diagnosis and mortality of colorectal cancer (CRC) over the past decade worldwide, as well as minor overall survival improvements in the industrialized world, suggest the need to shift from conventional research and clinical practice to the innovative development of screening, predictive and therapeutic tools. Explosive integration of next-generation sequencing (NGS) systems into basic, translational and, more recently, basket trials...
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Progress in understanding and overcoming fatal intrinsic and acquired resistance is slow, with only a few exceptions. Despite advances in modern genome and transcriptome analysis, the controversy of the three different theories on drug resistance and tumor progression, namely dynamic intratumor heterogeneity, pre-existing minor genomic clones and tumor ecosystem, is unresolved. Moreover, evidence on transcriptional heterogeneity suggests the necessity of a drug bank for individualized, precise d...
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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6 CitationsSource
Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Despite standardization of multimodal treatment and approval of several targeted drugs for resectable, non-metastatic cancer (M0 patients), intrinsic and acquired resistance and relapse rates remain high, even in early-stage aggressive tumors. Genome analysis could overcome these unmet needs. Our comprehensive review underlines the controversy on stable or spatiotemporally evolving clones as well as promising yet inconclusive data on genome-based biomarkers and drug development. We propose clini...
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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Last. Dimitrios H Roukos (Academy of Athens)H-Index: 4
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