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Jean G. Dumesnil
Laval University
264Publications
55H-index
12.7kCitations
Publications 264
Newest
#1Lionel Tastet (Laval University)H-Index: 9
#2Romain Capoulade (Laval University)H-Index: 18
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 17 authors...
BackgroundPrevious studies reported that middle‐aged patients with atherogenic lipoprotein‐lipid profile exhibit faster progression of aortic valve stenosis (AS). The ratio of apolipoprotein B/apol...
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#1Romain Capoulade (Laval University)H-Index: 18
#2Marie-Annick Clavel (Laval University)H-Index: 34
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 14 authors...
Aims The objective of this study was to examine the association between the different patterns of left ventricular (LV) remodelling/hypertrophy on all-cause and cardiovascular mortality in patients with aortic stenosis (AS). Methods and results In total, 747 consecutive patients (69 ± 14 years, 57% men) with AS and preserved LV ejection fraction were included in this study. According to LV mass index and relative wall thickness, patients were classified into four LV patterns: normal, concentric ...
13 CitationsSource
#1Marlène Dupuis (Laval University)H-Index: 1
#2Haïfa Mahjoub (Laval University)H-Index: 9
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 15 authors...
BackgroundThe timing of mitral valve surgery in asymptomatic patients with primary mitral regurgitation (MR) is controversial. We hypothesized that the forward left ventricular (LV) ejection fracti...
5 CitationsSource
#1Abdellaziz Dahou (Laval University)H-Index: 17
#2Marie-Annick Clavel (Laval University)H-Index: 34
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 11 authors...
Abstract Objectives The objective of this study was to determine the prognostic value of combined measures of B-type natriuretic peptide (BNP) and high-sensitivity cardiac troponin T (hsTnT) in patients with low-flow, low-gradient aortic stenosis (LF-LG AS) who had either a preserved or reduced left ventricular ejection fraction (LVEF). Background An elevated BNP level is associated with increased risk of mortality in patients with LF-LG AS. The incremental prognostic value of hsTnT in these pat...
6 CitationsSource
#1Romain Capoulade (Laval University)H-Index: 18
#2Kwan L. Chan (U of O: University of Ottawa)H-Index: 11
Last.Sotirios Tsimikas (UCSD: University of California, San Diego)H-Index: 69
view all 13 authors...
Abstract Background and aims Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC),...
2 CitationsSource
#1Lionel Tastet (Laval University)H-Index: 9
#2Romain Capoulade (Laval University)H-Index: 18
Last.Philippe Pibarot (Laval University)H-Index: 42
view all 14 authors...
Aims Hypertension is highly prevalent in patients with aortic stenosis (AS) and is associated with worse outcomes. The current prospective study assessed the impact of systolic hypertension (SHPT) on the progression of aortic valve calcification (AVC) measured by multidetector computed tomography (MDCT) in patients with AS. Methods and results The present analysis includes the first series of 101 patients with AS prospectively recruited in the PROGRESSA study. Patients underwent comprehensive Do...
18 CitationsSource
#1Abdellaziz DahouH-Index: 17
#2Marie-Annick ClavelH-Index: 34
Last.Philippe PibarotH-Index: 65
view all 11 authors...
Paradoxical low-flow, low-gradient aortic stenosis (PLF-LG AS) is a recently described and recognized entity of AS characterized by low-flow status, defined as a stroke volume index (SVi) <35 ml/m2, a small aortic valve area (AVA: <1.0 cm2 and indexed AVA: <0.6 cm2/m2), a low-gradient (mean
4 CitationsSource
#1Mylène Shen (Laval University)H-Index: 6
#2Lionel Tastet (Laval University)H-Index: 9
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 11 authors...
Objective To evaluate the effect of age and aortic valve anatomy (tricuspid (TAV) vs bicuspid (BAV) aortic valve) on the relationship between the aortic valve calcification (AVC) and the haemodynamic parameters of aortic stenosis (AS) severity. Methods Two hundred patients with AS and preserved left ventricular ejection fraction were prospectively recruited in the PROGRESSA (Metabolic Determinants of the Progression of Aortic Stenosis) study and underwent a comprehensive Doppler echocardiography...
13 CitationsSource
Prosthesis-patient mismatch (PPM) is present when the effective orifice area of the inserted prosthetic valve is too small in relation to body size. Its main hemodynamic consequence is to generate higher than expected gradients through normally functioning prosthetic valves. The purpose of this review is to present an update on the present state of knowledge with regards to diagnosis, prognosis and prevention of PPM. PPM is a frequent occurrence (20%–70% of aortic valve replacements) that has be...
4 Citations
#1Abdellaziz Dahou (Laval University)H-Index: 17
#2Oumhani Toubal (Laval University)H-Index: 3
Last.Philippe Pibarot (Laval University)H-Index: 65
view all 13 authors...
Background: The QT interval has been shown to be associated with cardiovascular events. There is no data available on the association between the QT interval and left ventricular (LV) function and ...
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