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Bernhard Rupp
AmeriCorps VISTA
ChemistryCrystallizationBiochemistryCrystallographyBiology
122Publications
32H-index
3,389Citations
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Publications 122
Newest
#1Bernd SchöpfH-Index: 4
Last. Irina Giese (University of Mainz)
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Rewiring of energy metabolism and adaptation of mitochondria are considered to impact on prostate cancer development and progression. Here, we report on mitochondrial respiration, DNA mutations and gene expression in paired benign/malignant human prostate tissue samples. Results reveal reduced respiratory capacities with NADH-pathway substrates glutamate and malate in malignant tissue and a significant metabolic shift towards higher succinate oxidation, particularly in high-grade tumors. The loa...
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Last. Matthew W. BowlerH-Index: 23
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Afamin, which is a human blood plasma glycoprotein, a putative multifunctional transporter of hydrophobic molecules and a marker for metabolic syndrome, poses multiple challenges for crystallographic structure determination, both practically and in analysis of the models. Several hundred crystals were analysed, and an unusual variability in cell volume and difficulty in solving the structure despite an approximately 34% sequence identity with nonglycosylated human serum albumin indicated that th...
1 CitationsSource
#1Janis Fricke (Schiller International University)H-Index: 4
Last. Dirk Hoffmeister (FSU: University of Jena)H-Index: 26
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#1Bernd SchöpfH-Index: 4
Last. Helmut KlockerH-Index: 56
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Last. Matthew W. BowlerH-Index: 23
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Afamin, a human blood plasma glycoprotein, a putative multi-functional transporter of hydrophobic molecules and a marker for metabolic syndrome, poses multiple challenges for crystallographic structure determination, both practically and in analysis of the models. Several hundred crystals were analysed, and unusual variability in cell volume and difficulty solving the structure despite a ~34% sequence identity with non-glycosylated human serum albumin indicated that the molecule exhibits variabl...
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#1Alexander WlodawerH-Index: 65
#2Zbigniew DauterH-Index: 54
Last. Bernhard RuppH-Index: 32
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Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin’s glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. For the purpose of studying the structure of afamin, various forms of recombinantly expressed human afamin (rhAFM) with different glycosylation patterns were thus created. Wild-type rhAFM and various hypoglycosylated forms were expressed in CHO, CHO-Lec1, and HEK293T cells....
3 CitationsSource
#1Alexander WlodawerH-Index: 65
#2Zbigniew Dauter (Argonne National Laboratory)H-Index: 54
Last. Bernhard Rupp (AmeriCorps VISTA)H-Index: 32
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The massive technical and computational progress of biomolecular crystallography has generated some adverse side effects. Most crystal structure models, produced by crystallographers or well-trained structural biologists, constitute useful sources of information, but occasional extreme outliers remind us that the process of structure determination is not fail-safe. The occurrence of severe errors or gross misinterpretations raises fundamental questions: Why do such aberrations emerge in the firs...
11 CitationsSource
#2Alexander WlodawerH-Index: 65
Last. Bernhard RuppH-Index: 32
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#1Robyn L. StanfieldH-Index: 51
#2Bernhard RuppH-Index: 32
Last. C.X. WeichenbergerH-Index: 2
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