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Christopher J. LaRocca
University of Minnesota
20Publications
4H-index
38Citations
Publications 20
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#1Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
#2Eric H. Jensen (UMN: University of Minnesota)H-Index: 19
Colorectal cancer is the third leading cause of cancer deaths in both men and women with 136,830 new cases in the United States estimated to be diagnosed in 2014 [1]. For individuals diagnosed with colorectal cancer, approximately 20% of patients will have metastatic disease at the time of initial diagnosis [2]. Despite the overall incidence of colorectal cancer declining, the number of patients presenting with metastases has remained relatively unchanged. In multiple population-based studies, t...
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Oncolytic viruses have emerged as a novel class of anti-cancer therapeutics with one virus already receiving United States Food and Drug Administration (FDA) approval (talimogene laherparepvec) and many others undergoing testing in clinical trials. These viruses have direct lytic effects on tumor cells as well as immunomodulatory functions to increase inflammatory cell infiltrates in the tumor microenvironment. Despite all of the advances in cancer care, pancreatic cancer remains a highly lethal...
1 CitationsSource
#2Joohee Han (UMN: University of Minnesota)H-Index: 5
Last.Julia DavydovaH-Index: 16
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// Amanda O. Salzwedel 1 , Joohee Han 1 , Christopher J. LaRocca 1 , Ryan Shanley 2 , Masato Yamamoto 1, 3, 4 and Julia Davydova 1, 4 1 Department of Surgery, University of Minnesota, Minneapolis, MN 55455, USA 2 Biostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA 3 Institute of Molecular Virology, University of Minnesota, Minneapolis, MN 55455, USA 4 Masonic Cancer Center, University of Minnesota, Minneapolis, MN 55455, USA Correspondence to: Julia Dav...
7 CitationsSource
#1Jing Li HuangH-Index: 2
#2Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
Last.Masato YamamotoH-Index: 33
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Oncolytic adenoviruses (OAds) are increasingly recognized as vectors for immunotherapy in the treatment of various solid tumors. The myriads of advantages of using adenovirus include targeted specificity upon infection and selective replication, which lead to localized viral burst, exponential spread of OAds, and antitumor effect. OAds can also induce a strong immune reaction due to the massive release of tumor antigens upon cytolysis and the presence of viral antigens. This review will highligh...
5 CitationsSource
#1Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
#2Greg J. BeilmanH-Index: 1
Last.Martin BirchH-Index: 1
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Pseudocholinesterase deficiencies occur because of both genetic and acquired factors. We present the case of a patient with a history of bariatric surgery and severe malnutrition who subsequently developed prolonged neuromuscular blockade after succinylcholine administration. She had markedly decreased pseudocholinesterase levels at the time of the incident, but her motor function returned to normal with supportive care. After aggressive nutritional support over multiple weeks, her pseudocholine...
1 CitationsSource
#1Jing-Li Huang (UMN: University of Minnesota)
#2Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
Last.Masato Yamamoto (UMN: University of Minnesota)H-Index: 33
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#1Amanda O. Salzwedel (UMN: University of Minnesota)H-Index: 2
#2Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
Last.Masato Yamamoto (UMN: University of Minnesota)H-Index: 33
view all 5 authors...
Aside from curative resection, there is no curative treatment against pancreatic adenocarcinoma (PDAC) at present. Late diagnosis and high recurrence results in five-year survival of 6%. Notably, Phase II trials based on adjuvant therapy combining systemic IFN Alpha (IFN) and chemoradiation reported 30-50% increase in two-year survival and impressive 35% increase in five-year survival of PDAC patients. Despite promising results, trial drawbacks included high patient dropout due to IFN systemic t...
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#1Christopher J. LaRocca (UMN: University of Minnesota)H-Index: 4
#2Joohee Han (UMN: University of Minnesota)H-Index: 5
Last.Masato Yamamoto (UMN: University of Minnesota)H-Index: 33
view all 7 authors...
Summary Objectives In recent years, the incidence of Human Papilloma Virus (HPV)-positive head and neck squamous cell carcinomas (HNSCC) has markedly increased. Our aim was to design a novel therapeutic agent through the use of conditionally replicative adenoviruses (CRAds) that are targeted to the HPV E6 and E7 oncoproteins. Methods Each adenovirus included small deletion(s) in the E1a region of the genome (Δ24 or CB016) intended to allow for selective replication in HPV-positive cells. In vitr...
6 CitationsSource
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