Emily S. Wan
Harvard University
Genome-wide association studyPhysical therapyCOPDDiseaseMedicine
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Publications 67
#1Spyridon Fortis (UI: University of Iowa)H-Index: 6
#2Alejandro P. Comellas (UI: University of Iowa)H-Index: 24
Last. Emily S. Wan (Brigham and Women's Hospital)H-Index: 20
view all 8 authors...
One quarter of individuals with Preserved Ratio Impaired Spirometry (PRISm) will develop airflow obstruction, but there are no established methods to identify these individuals. We examined the utility of FVC/TLC in identifying features of obstructive lung disease. The ratio of post-bronchodilator FVC and TLCCT from chest CT (FVC/TLCCT) among current and former smokers with PRISm (FEV1/FVC ≥ 0.7 and FEV1 < 80%) in COPDGene was used to stratify subjects into quartiles: very high, high, low, and v...
#1Emily S. WanH-Index: 20
#2Ana KantorowskiH-Index: 2
Last. Marilyn L. MoyH-Index: 22
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Abstract Background Technology-based physical activity (PA) interventions have been shown to improve daily step counts and health-related quality of life, but their effect on long-term clinical outcomes like acute exacerbations (AEs) is unknown in persons with COPD. Methods U.S. Veterans with stable COPD were randomized (1:1) to either pedometer alone (control) or pedometer plus a website with feedback, goal-setting, disease education, and a community forum (intervention) for 3 months. AEs were ...
1 CitationsSource
#1Peter J. Castaldi (Brigham and Women's Hospital)H-Index: 25
#2Adel Boueiz (Brigham and Women's Hospital)
Last. John E. Hokanson (University of Colorado Denver)H-Index: 58
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Abstract COPD is a heterogeneous syndrome. Many COPD subtypes have been proposed, but there is not yet consensus on how many COPD subtypes there are and how they should be defined. The COPDGene study, which has generated ten-year longitudinal chest imaging, spirometry, and molecular data, is a rich resource for relating COPD phenotypes to underlying genetic and molecular mechanisms. In this article, we place COPDGene clustering studies in context with other highly cited COPD clustering studies, ...
#1Priyadarshini Kachroo (Brigham and Women's Hospital)H-Index: 4
#2Julian Hecker (Harvard University)H-Index: 5
Last. Sebastian ZoellnerH-Index: 3
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ABSTRACT Background Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based ‘Genetic Epidemiology of Asthma in Costa Rica’ study. Asthma affection ...
Background: Chronic obstructive pulmonary disease (COPD) remains a major cause of morbidity and mortality. Present-day diagnostic criteria are largely based solely on spirometric criteria. Accumulating evidence has identified a substantial number of individuals without spirometric evidence of COPD who suffer from respiratory symptoms and/or increased morbidity and mortality. There is a clear need for an expanded definition of COPD that is linked to physiologic, structural (computed tomography [C...
#1Emily S. Wan (Harvard University)H-Index: 20
#2Rebekah L. Goldstein (VA Boston Healthcare System)H-Index: 2
Last. Marilyn L. Moy (Harvard University)H-Index: 22
view all 9 authors...
Rationale Shorter leukocyte telomere length (LTL) is associated with reduced health-related quality of life and increased risk for acute exacerbations (AEs) and mortality in chronic obstructive pulmonary disease (COPD). Increased physical activity and exercise capacity are associated with reduced risk for AEs and death. However, the relationships between LTL and physical activity, exercise capacity, and AEs in COPD are unknown. Methods Data from 3 COPD cohorts were examined: Cohort 1 (n = 112, p...
#1Victor Kim (TU: Temple University)H-Index: 23
#2H. Zhao (TU: Temple University)H-Index: 4
Last. Mario E. RuizH-Index: 5
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Background Chronic bronchitis (CB) increases risk of COPD exacerbations. We have shown that the St. George’s Respiratory Questionnaire (SGRQ) CB definition identifies patients with a similar clinical phenotype as classically defined CB. Whether the SGRQ CB definition is a predictor of future COPD exacerbations is unknown. Methods We analyzed 7,557 smokers with normal spirometry and Global Initiative for Chronic Obstructive Lung Disease stage 1-4 COPD in the Genetic Epidemiology of COPD study wit...
1 CitationsSource
#1Diego J. MaselliH-Index: 11
#2Surya P. Bhatt (UAB: University of Alabama at Birmingham)H-Index: 24
Last. Barry J. MakeH-Index: 55
view all 21 authors...
The Genetic Epidemiology of COPD (COPDGene) study is a noninterventional, multicenter, longitudinal analysis of > 10,000 subjects, including smokers with a ≥ 10 pack-year history with and without COPD and healthy never smokers. The goal was to characterize disease-related phenotypes and explore associations with susceptibility genes. The subjects were extensively phenotyped with the use of comprehensive symptom and comorbidity questionnaires, spirometry, CT scans of the chest, and genetic and bi...
1 CitationsSource
#1Emily S. Wan (Brigham and Women's Hospital)H-Index: 20
#2Edwin K. Silverman (Brigham and Women's Hospital)H-Index: 94