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Alexander W. Caulk
Yale University
17Publications
6H-index
83Citations
Publications 17
Newest
#1Bart Spronck (UM: Maastricht University)H-Index: 7
#2Alexander W. Caulk (Yale University)H-Index: 6
Last.D HumphreyJay (Yale University)H-Index: 56
view all 9 authors...
Objective: Many genetically-induced mutations affect aortic structure and function in mice, but little is known about the influence of background strain. This study quantifies the aortic phenotype in angiotensin II (AngII)-induced hypertension across different strains of wild-type mice. Approach and Results: Adult male C57BL/6J and 129SvEv mice were studied before and after induction of hypertension via subcutaneous infusion of AngII (1000 ng/kg/min) for two weeks, which elevated blood pressure ...
#1A. W. Caulk (UVA: University of Virginia)
Simple multilinear methods, such as partial least squares regression (PLSR), are effective at interrelating dynamic, multivariate datasets of cell-molecular biology through high-dimensional arrays. However, data collected in vivo are more difficult, because animal-to-animal variability is often high, and each time-point measured is usually a terminal endpoint for that animal. Observations are further complicated by the nesting of cells within tissues or tissue sections, which themselves are nest...
#1J. Ferruzzi (Yale University)H-Index: 10
#2D. Madziva (Yale University)H-Index: 1
Last.D HumphreyJay (Yale University)H-Index: 56
view all 5 authors...
Aging leads to central artery stiffening and associated hemodynamic sequelae. Because healthy arteries exhibit differential geometry, composition, and mechanical behaviors along the central vasculature, we sought to determine whether wall structure and mechanical function differ across five vascular regions—the ascending and descending thoracic aorta, suprarenal and infrarenal abdominal aorta, and common carotid artery—in 20 versus 100-week-old male wild-type mice. Notwithstanding generally cons...
#1Alexander W. Caulk (Yale University)H-Index: 6
#2George Tellides (Yale University)H-Index: 44
Last.D HumphreyJay (Yale University)H-Index: 56
view all 3 authors...
Abstract Since the mid-1970s, it has been increasingly recognized that vascular cells—endothelial, smooth muscle, and fibroblasts—are highly sensitive to mechanical stimuli, changing their gene expression profile in response to changes in mechanics. Such changes explain many observed vascular adaptations to perturbations in hemodynamics and certain pathologies. Similar to mechanical loading, inflammation also affects the extent of many vascular adaptations and disease progression. In this chapte...
#1Guangxin Li (PRC: China Medical University (PRC))H-Index: 1
#2Lingfeng Qin (Yale University)H-Index: 21
Last.Shijie Xin (PRC: China Medical University (PRC))H-Index: 12
view all 8 authors...
This study provides novel observations that mechanistic target of rapamycin (mTOR) signaling is overactivated in aortic smooth muscle cells and contributes to mouse abdominal aortic aneurysm (AAA) ...
#1Chiara Bellini (Yale University)H-Index: 10
#2Matthew R. Bersi (Yale University)H-Index: 11
Last.D HumphreyJay (Yale University)H-Index: 56
view all 10 authors...
Thoracic aortic aneurysms are life-threatening lesions that afflict young and old individuals alike. They frequently associate with genetic mutations and are characterized by reduced elastic fibre integrity, dysfunctional smooth muscle cells, improperly remodelled collagen and pooled mucoid material. There is a pressing need to understand better the compromised structural integrity of the aorta that results from these genetic mutations and renders the wall vulnerable to dilatation, dissection or...
Objective—Williams syndrome is characterized by obstructive aortopathy attributable to heterozygous loss of ELN, the gene encoding elastin. Lesions are thought to result primarily from excessive smooth muscle cell (SMC) proliferation and consequent medial expansion, although an initially smaller caliber and increased stiffness of the aorta may contribute to luminal narrowing. The relative contributions of such abnormalities to the obstructive phenotype had not been defined. Approach and Results—...
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