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A.K. Wernimont
University of Toronto
206Publications
16H-index
1,037Citations
Publications 206
Newest
#1Majida El Bakkouri (Institut national de la recherche scientifique)H-Index: 14
#2Imène Kouidmi (Institut national de la recherche scientifique)
Last.Raymond Hui (U of T: University of Toronto)H-Index: 24
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The cyclic guanosine-3′,5′-monophosphate (cGMP)-dependent protein kinase (PKG) was identified >25 y ago; however, efforts to obtain a structure of the entire PKG enzyme or catalytic domain from any species have failed. In malaria parasites, cooperative activation of PKG triggers crucial developmental transitions throughout the complex life cycle. We have determined the cGMP-free crystallographic structures of PKG from Plasmodium falciparum and Plasmodium vivax, revealing how key structural compo...
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#1K. LiuH-Index: 6
Last.Jinrong MinH-Index: 37
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#1Chuanbing BianH-Index: 12
Last.Jinrong MinH-Index: 37
view all 8 authors...
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#1K. LiuH-Index: 6
#2Chuanbing BianH-Index: 12
Last.Jinrong MinH-Index: 37
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#1Stephen N. HewittH-Index: 10
#2David M. DranowH-Index: 5
Last.W.C. Van VoorhisH-Index: 53
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Plasmodium falciparum (Pf) prolyl-tRNA synthetase (ProRS) is one of the few chemical-genetically validated drug targets for malaria, yet highly selective inhibitors have not been described. In this paper, approximately 40,000 compounds were screened to identify compounds that selectively inhibit PfProRS enzyme activity versus Homo sapiens (Hs) ProRS. X-ray crystallography structures were solved for apo, as well as substrate- and inhibitor-bound forms of PfProRS. We identified two new inhibitors ...
12 CitationsSource
#1John R. WalkerH-Index: 50
Last.Yufeng TongH-Index: 19
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#1John R. WalkerH-Index: 50
Last.Yufeng TongH-Index: 19
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#1A.K. WernimontH-Index: 16
#2Wolfram TempelH-Index: 27
Last.M. El BakkouriH-Index: 1
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#1Chao Xu (USTC: University of Science and Technology of China)H-Index: 29
#2Zhihong Li (SGC: Structural Genomics Consortium)H-Index: 5
Last.Jinrong Min (U of T: University of Toronto)H-Index: 37
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Nuclear pore complexes (NPC) form nuclear pores that cross the nuclear envelope and allow molecules to transport between the nucleus and the cytoplasm. We solved the crystal structure of human Nup43 (hNUP43), an important component in the Nup107 subcomplex of NPC. hNup43 adopts a seven-bladed β-propeller fold. We confirmed by ITC that neither human Nup37 (hNup37) nor human Nup133 (hNup133) interacts with hNup43. We demonstrated by analytical gel filtration that the human Nup85-Seh1L binary compl...
6 CitationsSource
#1A.K. WernimontH-Index: 16
#2Wolfram TempelH-Index: 27
Last.M. El BakkouriH-Index: 1
view all 16 authors...
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