Brett L. Ecker
Wistar Institute
CancerSurgeryPancreatic fistulaGeneral surgeryMedicine
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Publications 72
#1Bofeng Chen (UPenn: University of Pennsylvania)H-Index: 2
#2Maxwell T. Trudeau (UPenn: University of Pennsylvania)
Last. Charles M. Vollmer (UPenn: University of Pennsylvania)H-Index: 40
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Background Hyperbilirubinemia is commonly observed in patients requiring pancreatoduodenectomy (PD). Thus far, literature regarding the danger of operating in the setting of hyperbilirubinemia is equivocal. What remains undefined is at what specific level of bilirubin there is an adverse safety profile for undergoing PD. The aim of this study is to identify the optimal safety profile of patients with hyperbilirubinemia undergoing PD.
#1Marie R. Webster (Wistar Institute)H-Index: 14
#2Mitchell E. Fane (Wistar Institute)H-Index: 5
Last. Ashani T. Weeraratna (Wistar Institute)H-Index: 37
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Summary Metastatic melanoma is an aggressive disease, despite recent improvements in therapy. Eradicating all melanoma cells even in drug-sensitive tumors is unsuccessful in patients because a subset of cells can transition to a slow-cycling state, rendering them resistant to most targeted therapy. It is still unclear what pathways define these subpopulations and promote this resistant phenotype. In the current study, we show that Wnt5A, a non-canonical Wnt ligand that drives a metastatic, thera...
#1Marie R. WebsterH-Index: 14
#2Mitchell E. FaneH-Index: 5
Last. Keerthana GnanapradeepanH-Index: 2
view all 32 authors...
#1Maxwell T. Trudeau (UPenn: University of Pennsylvania)
#2Laura Maggino (UPenn: University of Pennsylvania)H-Index: 10
Last. Charles M. Vollmer (UPenn: University of Pennsylvania)H-Index: 40
view all 4 authors...
Purpose This study aimed to identify optimal management decisions for surgeons preforming pancreatic head resection on patients with altered anatomy due to a previous Roux-en-Y gastric bypass (RYGB).
#1Brett L. Ecker (UPenn: University of Pennsylvania)H-Index: 12
#2Charles M. Vollmer (UPenn: University of Pennsylvania)H-Index: 40
Last. Paxton V. Dickson (UTHSC: University of Tennessee Health Science Center)H-Index: 8
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Importance Ampullary adenocarcinoma is a rare malignant neoplasm that arises within the duodenal ampullary complex. The role of adjuvant therapy (AT) in the treatment of ampullary adenocarcinoma has not been clearly defined. Objective To determine if long-term survival after curative-intent resection of ampullary adenocarcinoma may be improved by selection of patients for AT directed by histologic subtype. Design, Setting, and Participants This multinational, retrospective cohort study was condu...
1 CitationsSource
#1Thomas F. SeykoraH-Index: 2
#2Brett L. EckerH-Index: 12
Last. Charles M. VollmerH-Index: 40
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OBJECTIVE:The aim of this study was to elucidate the impact of intraoperative blood loss on outcomes following pancreatoduodenectomy (PD). BACKGROUND:The negative impact of intraoperative blood loss on outcomes in PD has long been suspected but not well characterized, particularly those factors that may be within surgeons' control. METHODS:From 2001 to 2015, 5323 PDs were performed by 62 surgeons from 17 institutions. Estimated blood loss (EBL) was discretized (0 to 300, 301 to 750, 751 to 1300,...
4 CitationsSource
#1Yun Song (HUP: Hospital of the University of Pennsylvania)H-Index: 3
#2Brett L. Ecker (HUP: Hospital of the University of Pennsylvania)H-Index: 12
Last. Giorgos C. Karakousis (HUP: Hospital of the University of Pennsylvania)H-Index: 29
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Abstract Background Soft tissue sarcomas (STS) represent a rare and heterogeneous group of tumors. We sought to characterize national trends in referral patterns, treatment strategies, and overall survival (OS) over the course of a decade. Methods Adult patients with extra-abdominal STS were identified using the National Cancer Database and categorized by diagnosis year (2005–2009 and 2010–2014). High-volume hospitals (HVH) were defined as those >90th percentile in volume of STS patients treated...
#1Brett L. Ecker (UPenn: University of Pennsylvania)H-Index: 12
#2Jun Y. Lee (UPenn: University of Pennsylvania)H-Index: 1
Last. Lewis A. Chodosh (UPenn: University of Pennsylvania)H-Index: 50
view all 13 authors...
Obesity is associated with an increased risk of breast cancer recurrence and cancer death. Recurrent cancers arise from the pool of residual tumor cells, or minimal residual disease (MRD), that survives primary treatment and persists in the host. Whether the association of obesity with recurrence risk is causal is unknown, and the impact of obesity on MRD and breast cancer recurrence has not been reported in humans or in animal models. Doxycycline-inducible primary mammary tumors were generated ...
4 CitationsSource