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Adithya Cattamanchi
University of California, San Francisco
ImmunologySputumMycobacterium tuberculosisTuberculosisMedicine
184Publications
30H-index
3,364Citations
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Publications 183
Newest
#1Devan Jaganath (UCSF: University of California, San Francisco)H-Index: 14
#2Jayant V. Rajan (UCSF: University of California, San Francisco)H-Index: 4
Last. Fred C. Semitala (MUK: Makerere University)H-Index: 9
view all 12 authors...
Better triage tests for screening tuberculosis (TB) disease are needed for people living with HIV (PLHIV). We performed the first evaluation of a previously-validated 8-antigen serological panel to screen PLHIV for pulmonary TB in Kampala, Uganda. We selected a random 1:1 sample with and without TB (defined by sputum culture) from a cohort of PLHIV initiating antiretroviral therapy. We used a multiplex microbead immunoassay and an ensemble machine learning classifier to determine the area under ...
Source
#1Sky Vanderburg (UCSF: University of California, San Francisco)H-Index: 1
#2Narges Alipanah (UCSF: University of California, San Francisco)H-Index: 8
Last. John Z. Metcalfe (UCSF: University of California, San Francisco)H-Index: 20
view all 22 authors...
Background: Following early implementation of public health measures, San Francisco has experienced a slow rise and a low peak level of coronavirus disease 2019 (COVID-19) cases and deaths. Methods and Findings: We included all patients with COVID-19 pneumonia admitted to the intensive care unit (ICU) at the safety net hospital for San Francisco through April 8, 2020. Each patient had ≥15 days of follow-up. Among 26 patients, the median age was 54 years (interquartile range, 43 to 62), 65% were ...
5 CitationsSource
#1Tania Reza (UCSF: University of California, San Francisco)H-Index: 1
#2Talemwa NalugwaH-Index: 3
Last. Austin Tucker (Johns Hopkins University)H-Index: 2
view all 20 authors...
BACKGROUND: Delays in diagnosis and treatment of tuberculosis (TB) remain common in high-burden countries. To improve case detection, substantial investments have been made to scale-up Xpert MTB/RIF (Xpert), a cartridge-based nucleic acid amplification test that can detect TB within 2 hours, as a replacement for sputum smear microscopy. However, the optimal strategy for implementation of Xpert testing remains unclear. METHODS: The Xpert Performance Evaluation for Linkage to Tuberculosis Care (XP...
Source
#1Priya B. Shete (UCSF: University of California, San Francisco)H-Index: 8
#2Ralph Gonzales (UCSF: University of California, San Francisco)H-Index: 50
Last. Margaret A. Handley (UCSF: University of California, San Francisco)H-Index: 21
view all 5 authors...
Purpose We evaluated outcomes of trainees who have completed Certificate program in Implementation Science at the University of California San Francisco. Methods All students who completed the in-person Certificate Program (2008-2015), or the online Certificate Program (2016-2017) were eligible for our study. We assessed the potential impact of the Certificate Program on the professional development of trainees, through participant surveys on their self-reported level of comfort with pre-defined...
1 CitationsSource
#1Andrew D. Kerkhoff (UCSF: University of California, San Francisco)H-Index: 18
#2Monde Muyoyeta (Centre for Infectious Disease Research in Zambia)H-Index: 1
Last. Adithya Cattamanchi (UCSF: University of California, San Francisco)H-Index: 30
view all 3 authors...
Source
#1Nisha Gupta (UCSF: University of California, San Francisco)H-Index: 1
#2Adithya Cattamanchi (UCSF: University of California, San Francisco)H-Index: 30
Last. Sunitha V. Kaiser (UCSF: University of California, San Francisco)H-Index: 6
view all 6 authors...
AbstractObjective:Pathways are succinct, operational versions of evidence-based guidelines. Studies have demonstrated pathways improve quality of care for children hospitalized with asthma, but we ...
Source
#1Talemwa Nalugwa (MUK: Makerere University)H-Index: 3
#2Priya B. Shete (UCSF: University of California, San Francisco)H-Index: 8
Last. Moore Daj
view all 13 authors...
BACKGROUND: Many high burden countries are scaling-up GeneXpert(R) MTB/RIF (Xpert) testing for tuberculosis (TB) using a hub-and-spoke model. However, the effect of scale up on reducing TB has been limited. We sought to characterize variation in implementation of referral-based Xpert TB testing across Uganda, and to identify health system factors that may enhance or prevent high-quality implementation of Xpert testing services. METHODS: We conducted a cross-sectional study triangulating quantita...
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#1Adithya Cattamanchi (UCSF: University of California, San Francisco)H-Index: 30
#2Christopher A. Berger (UCSF: University of California, San Francisco)H-Index: 2
Last. Achilles Katamba (MUK: Makerere University)H-Index: 17
view all 8 authors...
Abstract Nucleic acid amplification tests such as Xpert MTB/RIF (Xpert) have the potential to revolutionize tuberculosis (TB) diagnostics and improve case finding in resource-poor settings. However, since its introduction over a decade ago in Uganda, there remain significant gaps along the cascade of care for patients undergoing TB diagnostic evaluation at peripheral health centers. We utilized a systematic, implementation science-based approach to identify key reasons at multiple levels for att...
2 CitationsSource
#1Alfred Andama (MUK: Makerere University)H-Index: 8
#2Devan Jaganath (UCSF: University of California, San Francisco)H-Index: 14
Last. Adithya CattamanchiH-Index: 30
view all 13 authors...
Abstract The performance of urine Xpert MTB/RIF Ultra (Xpert Ultra) for pulmonary TB diagnosis is unknown. HIV-positive and HIV-negative adults were enrolled at two health facilities in Kampala, Uganda. We compared the accuracy of urine Xpert Ultra and Determine TB-LAM in reference to sputum-based testing (positive Xpert MTB/RIF or culture), and assessed incremental yield. Urine Xpert Ultra had low sensitivity (17.2%, 95% CI 12.3–23.2) but high specificity (98.1%, 95% CI 94.4–99.6). Sensitivity ...
2 CitationsSource
#1Bruce D. Agins (CUNY: City University of New York)H-Index: 14
#2Daniel J Ikeda (Harvard University)H-Index: 1
Last. Adithya Cattamanchi (UCSF: University of California, San Francisco)H-Index: 30
view all 6 authors...
Summary Tuberculosis is preventable, treatable, and curable, yet it has the highest mortality rate of infectious diseases worldwide. Over the past decade, services to prevent, screen, diagnose, and treat tuberculosis have been developed and scaled up globally, but progress to end the disease as a public health threat has been slow, particularly in low-income and middle-income countries. In these settings, low-quality tuberculosis prevention, diagnostic, and treatment services frustrate efforts t...
8 CitationsSource
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