Ken Sikaris
University of Melbourne
Publications 143
#1Tony BadrickH-Index: 12
#2Giuseppe BanfiH-Index: 34
Last.Ken SikarisH-Index: 24
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Medicine has traditionally relied on heuristic approaches in which knowledge is acquired through experience and self-learning. Pathology is information rich with quantitative and qualitative measurements such as history, images, and physiological data from which diagnosis and treatment decisions are made. This information is readily linked to patient outcome data and is therefore potentially invaluable in improving treatment. Thus, pathology is ripe for the application of tools that can effectiv...
#2Kwong Chun LiuH-Index: 1
Last.Ken SikarisH-Index: 24
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2 CitationsSource
#1Catherine LynchH-Index: 1
#2Tina YenH-Index: 5
Last.Ken SikarisH-Index: 24
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#1Christina C. ChangH-Index: 16
#2Vivek Naranbhai (University of Oxford)H-Index: 19
Last.Sharon R. LewinH-Index: 58
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OBJECTIVE(S):To determine whether variation in cell-associated unspliced (CA-US) HIV RNA in HIV-infected individuals on antiretroviral therapy (ART) has a circadian basis. METHODS:Prospective observational study of HIV-infected individuals on ART. Blood was collected on three occasions and CA-US HIV RNA and mRNA of the circadian-locomotor-output-cycles-kaput (CLOCK)-associated genes quantified by real time PCR. CLOCK-associated proteins were over-expressed in a cell line stably transfected with ...
4 CitationsSource
#1Yesim Ozarda (Uludağ University)H-Index: 12
#2Ken Sikaris (University of Melbourne)H-Index: 24
Last.Decision LimitsH-Index: 1
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AbstractReference Intervals (RIs) and clinical decision limits (CDLs) are a vital part of the information supplied by laboratories to support the interpretation of numerical clinical pathology results. RIs describe the typical distribution of results seen in a healthy reference population while CDLs are associated with a significantly higher risk of adverse clinical outcomes or are diagnostic for the presence of a specific disease. However, as the two concepts are sometimes confused, there is a ...
6 CitationsSource
#1Douglas Boyle (University of Melbourne)H-Index: 12
#2Vincent L. Versace (Deakin University)H-Index: 14
Last.James D. Best (NTU: Nanyang Technological University)H-Index: 49
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OBJECTIVE: Gestational Diabetes Mellitus (GDM) increases the risk of type 2 diabetes. A register can be used to follow-up high risk women for early intervention to prevent progression to type 2 diabetes. We evaluate the performance of the world's first national gestational diabetes register. RESEARCH DESIGN AND METHODS: Observational study that used data linkage to merge: (1) pathology data from the Australian states of Victoria (VIC) and South Australia (SA); (2) birth records from the Consulta...
7 CitationsSource
#1Geoffrey S. Baird (UW: University of Washington)H-Index: 23
#2Brian R. Jackson (UofU: University of Utah)H-Index: 13
Last.Michael Laposata (UTMB: University of Texas Medical Branch)H-Index: 47
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The first automobile accident in the US occurred in 1891, only 6 years after Karl Benz developed the first gasoline-powered production automobile. Less poorly documented is the interval of time that elapsed between Yalow's invention of the immunoassay, Mullis' development of the polymerase chain reaction, or Fenn's demonstration of electrospray mass spectrometry and the first orders for clinical laboratory tests based on these technologies that were placed on the wrong patients, for the wrong re...
#1Gus KoerbinH-Index: 14
#2Ken SikarisH-Index: 24
Last.Jillian R. TateH-Index: 13
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#1Geraldine J. Ooi (Monash University)H-Index: 6
#2Arul Earnest (Monash University)H-Index: 32
Last.Wendy A. Brown (Monash University)H-Index: 30
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Introduction Dyslipidemia affects up to 75% of morbidly obese individuals and is a key driver of cardiovascular disease. Weight loss is an established strategy to improve metabolic risk, including dyslipidemia. We aimed to determine weight loss goals for resolution of serum lipid abnormalities, by measuring improvements during progressive weight loss in obese individuals.
1 CitationsSource