Sven M. Carlsen
Norwegian University of Science and Technology
94Publications
24H-index
1,852Citations
Publications 94
Newest
Published on Apr 1, 2019in The Lancet Diabetes & Endocrinology 19.31
Tone Shetelig Løvvik2
Estimated H-index: 2
(Norwegian University of Science and Technology),
Sven M. Carlsen24
Estimated H-index: 24
(Norwegian University of Science and Technology)
+ 16 AuthorsAngelica Lindén Hirschberg31
Estimated H-index: 31
(Karolinska Institutet)
Summary Background Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications. Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group. The aim of this third randomised trial (PregMet2) was to test the hypothesis that metformin prevents late miscarriage and preterm birth in women with PCOS. Meth...
1 Citations Source Cite
Published on Mar 1, 2019in The Lancet Child & Adolescent Health
Liv Guro Engen Hanem2
Estimated H-index: 2
(Norwegian University of Science and Technology),
Øyvind Salvesen22
Estimated H-index: 22
(Norwegian University of Science and Technology)
+ 5 AuthorsEszter Vanky18
Estimated H-index: 18
(Norwegian University of Science and Technology)
Summary Background Metformin is increasingly used to treat gestational diabetes and type 2 diabetes in pregnancy, and in attempts to improve pregnancy outcomes in polycystic ovary syndrome and obesity. It passes across the placenta with possible long-term consequences for the offspring. We previously explored the effect of metformin, given to women with polycystic ovary syndrome during pregnancy, on children's growth up to 4 years of age. In this 5–10 year follow-up, we examined the cardiometabo...
1 Citations Source Cite
Published on Aug 16, 2018in International Journal of Endocrinology 2.34
Solhild Stridsklev4
Estimated H-index: 4
(Norwegian University of Science and Technology),
Øyvind Salvesen22
Estimated H-index: 22
(Norwegian University of Science and Technology)
+ 2 AuthorsEszter Vanky18
Estimated H-index: 18
(Norwegian University of Science and Technology)
The objective of this study was to investigate possible differences in uterine artery pulsatility index (UtAPI) between pregnant women with PCOS and healthy controls and to explore possible effects of metformin on UtAPI. Material and Methods. The study was conducted in a tertiary center. Forty-eight pregnant women diagnosed with PCOS before pregnancy and 124 healthy pregnant women were included. Women with PCOS were randomly assigned to metformin 2000 mg daily or a placebo. UtAPI was measured fi...
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Published on Oct 9, 2018in PLOS ONE 2.77
Marte Kierulf Åm (Norwegian University of Science and Technology), Konstanze Kölle2
Estimated H-index: 2
(Norwegian University of Science and Technology)
+ 7 AuthorsSverre Christian Christiansen9
Estimated H-index: 9
(Norwegian University of Science and Technology)
Background In diabetes research, the development of the artificial pancreas has been a major topic since continuous glucose monitoring became available in the early 2000’s. A prerequisite for an artificial pancreas is fast and reliable glucose sensing. However, subcutaneous continuous glucose monitoring carries the disadvantage of slow dynamics. As an alternative, we explored continuous glucose sensing in the peritoneal space, and investigated potential spatial differences in glucose dynamics wi...
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Published on Nov 15, 2018in F1000Research
Asgeir Store Jakola14
Estimated H-index: 14
(University of Gothenburg),
Katja Werlenius1
Estimated H-index: 1
(University of Gothenburg)
+ 13 AuthorsMagnus Lindskog10
Estimated H-index: 10
(Uppsala University)
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and experimental data suggest that copper may increase its anti-neoplastic properties. There is also some clinical evidence that DSF is a promising anticancer agent in extracranial cancers. In glioblastoma, DSF induced O 6 -methylguanine methyltransferase (MGMT) inhibition may incr...
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Published on Aug 23, 2018in PLOS ONE 2.77
Sasha Gulati17
Estimated H-index: 17
,
Ole Solheim24
Estimated H-index: 24
+ 7 AuthorsØyvind Salvesen22
Estimated H-index: 22
2 Citations Source Cite
Published on Oct 30, 2018in Health technology
Konstanze Kölle2
Estimated H-index: 2
(Norwegian University of Science and Technology),
Anders Lyngvi Fougner6
Estimated H-index: 6
(Norwegian University of Science and Technology)
+ 3 AuthorsØyvind Stavdahl21
Estimated H-index: 21
(Norwegian University of Science and Technology)
Closed-loop glucose control has the potential to improve the glycemic control in patients with diabetes mellitus type 1. Such an artificial pancreas (AP) should keep the user safe despite all disturbances and faults. The objective of this paper is to analyze those perturbations according to their effects on the glycemic status, and thereby supporting an informed design process of the control system. As suggested by the international standard ISO 14971 for risk management of medical devices, the ...
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Published on Oct 17, 2018in Biosensors
Odd Martin Staal1
Estimated H-index: 1
,
Heidi Marie Umbach Hansen + 3 AuthorsØyvind Stavdahl21
Estimated H-index: 21
Freestyle Libre (FL) is a factory calibrated Flash Glucose Monitor (FGM). We investigated Mean Absolute Relative Difference (MARD) between Self Monitoring of Blood Glucose (SMBG) and FL measurements in the first day of sensor wear in 39 subjects with Type 1 diabetes. The overall MARD was 12.3%, while the individual MARDs ranged from 4% to 25%. Five participants had a MARD ≥ 20%. We estimated bias and lag between the FL and SMBG measurements. The estimated biases range from −1.8 mmol / L to 1.4 m...
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Liv Guro Engen Hanem2
Estimated H-index: 2
(Norwegian University of Science and Technology),
Solhild Stridsklev4
Estimated H-index: 4
(Norwegian University of Science and Technology)
+ 5 AuthorsEszter Vanky18
Estimated H-index: 18
(Norwegian University of Science and Technology)
24 Citations Source Cite
Published on May 1, 2018in BMJ open diabetes research & care
Anne Jølle1
Estimated H-index: 1
(Norwegian University of Science and Technology),
Bjørn Olav Åsvold24
Estimated H-index: 24
+ 4 AuthorsKristian Midthjell40
Estimated H-index: 40
(Norwegian University of Science and Technology)
Objective Among individuals at high risk for diabetes identified through a population survey, we performed an intervention study with basic lifestyle advice aiming to prevent diabetes. Research design and methods Among 50 806 participants in the HUNT3 Survey (2006–2008), 5297 individuals with Finnish Diabetes Risc Score (FINDRISC ≥15 were invited to an oral glucose tolerance test (OGTT) and an education session with lifestyle advice, and 2634 (49.7%) attended. Among them, 2380 people without dia...
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