Match!
Sven M. Carlsen
Norwegian University of Science and Technology
EndocrinologyPregnancyMetforminDiabetes mellitusMedicine
95Publications
23H-index
1,989Citations
What is this?
Publications 100
Newest
#1Mattis A. Madsbu (NTNU: Norwegian University of Science and Technology)H-Index: 4
#2Øyvind Salvesen (NTNU: Norwegian University of Science and Technology)H-Index: 23
Last. Sasha Gulati (NTNU: Norwegian University of Science and Technology)H-Index: 18
view all 8 authors...
Background There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals.
Source
#1Marte Kierulf Åm (NTNU: Norwegian University of Science and Technology)H-Index: 1
#2Anders Lyngvi Fougner (NTNU: Norwegian University of Science and Technology)H-Index: 7
Last. Sverre Christian Christiansen (NTNU: Norwegian University of Science and Technology)H-Index: 10
view all 8 authors...
Source
#1Marte Kierulf Åm (NTNU: Norwegian University of Science and Technology)H-Index: 1
#2Anders Lyngvi Fougner (NTNU: Norwegian University of Science and Technology)H-Index: 7
Last. Sverre Christian Christiansen (NTNU: Norwegian University of Science and Technology)H-Index: 10
view all 8 authors...
Abstract The artificial pancreas requires fast and reliable glucose measurements. The peritoneal space has shown promising results, and in one of our studies we detected glucose changes in the peritoneal space already at the same time as in the femoral artery. The peritoneal lining is highly vascularised, covered by a single layer of mesothelial cells and therefore easily accessible for proper sensor technology, e.g. optical technology. We hypothesize that the rapid intraperitoneal glucose dynam...
Source
#1Anne Jølle (NTNU: Norwegian University of Science and Technology)H-Index: 1
#2Kristian Midthjell (NTNU: Norwegian University of Science and Technology)H-Index: 42
Last. Bjørn Olav ÅsvoldH-Index: 25
view all 7 authors...
Objective The Finnish Diabetes Risk Score (FINDRISC) is a recommended tool for type 2 diabetes prediction. There is a lack of studies examining the performance of the current 0–26 point FINDRISC scale. We examined the validity of FINDRISC in a contemporary Norwegian risk environment. Research design and methods We followed 47 804 participants without known diabetes and aged ≥20 years in the HUNT3 survey (2006–2008) by linkage to information on glucose-lowering drug dispensing in the Norwegian Pr...
1 CitationsSource
#1Konstanze Kölle (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Anders Lyngvi Fougner (NTNU: Norwegian University of Science and Technology)H-Index: 7
Last. Øyvind Stavdahl (NTNU: Norwegian University of Science and Technology)H-Index: 23
view all 5 authors...
In classical approaches for an artificial pancreas, continuous glucose monitoring (CGM) is the only measured variable used for insulin dosing and additional control functions. The CGM values are subject to time delays and slow dynamics between blood and the sensing location. These time lags compromise the controller’s performance in maintaining (near to) normal glucose levels. Meal information could enhance the control outcome. However, meal announcement by the user is not reliable, and it takes...
Source
#1Konstanze Kölle (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Anders Lyngvi Fougner (NTNU: Norwegian University of Science and Technology)H-Index: 7
Last. Øyvind Stavdahl (NTNU: Norwegian University of Science and Technology)H-Index: 23
view all 6 authors...
Closed-loop glucose control has the potential to improve the glycemic control in patients with diabetes mellitus type 1. Such an artificial pancreas (AP) should keep the user safe despite all disturbances and faults. The objective of this paper is to analyze those perturbations according to their effects on the glycemic status, and thereby supporting an informed design process of the control system. As suggested by the international standard ISO 14971 for risk management of medical devices, the ...
1 CitationsSource
#1Tone Shetelig Løvvik (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Sven M. Carlsen (NTNU: Norwegian University of Science and Technology)H-Index: 23
Last. Eszter Vanky (NTNU: Norwegian University of Science and Technology)H-Index: 19
view all 19 authors...
Summary Background Women with polycystic ovary syndrome (PCOS) have an increased risk of pregnancy complications. Epi-analysis of two previous randomised controlled trials that compared metformin with placebo during pregnancy in women with PCOS showed a significant reduction in late miscarriages and preterm births in the metformin group. The aim of this third randomised trial (PregMet2) was to test the hypothesis that metformin prevents late miscarriage and preterm birth in women with PCOS. Meth...
3 CitationsSource
#1Liv Guro Engen Hanem (NTNU: Norwegian University of Science and Technology)H-Index: 3
#2Øyvind Salvesen (NTNU: Norwegian University of Science and Technology)H-Index: 23
Last. Eszter Vanky (NTNU: Norwegian University of Science and Technology)H-Index: 19
view all 8 authors...
Summary Background Metformin is increasingly used to treat gestational diabetes and type 2 diabetes in pregnancy, and in attempts to improve pregnancy outcomes in polycystic ovary syndrome and obesity. It passes across the placenta with possible long-term consequences for the offspring. We previously explored the effect of metformin, given to women with polycystic ovary syndrome during pregnancy, on children's growth up to 4 years of age. In this 5–10 year follow-up, we examined the cardiometabo...
10 CitationsSource
#1Anne JølleH-Index: 1
#2Kristian MidthjellH-Index: 42
Last. Bjørn Olav ÅsvoldH-Index: 25
view all 7 authors...
#1Asgeir Store Jakola (University of Gothenburg)H-Index: 19
#2K Werlenius (University of Gothenburg)H-Index: 1
Last. Tora Skeidsvoll Solheim (NTNU: Norwegian University of Science and Technology)H-Index: 7
view all 16 authors...
Background: Disulfiram (DSF) is a well-tolerated, inexpensive, generic drug that has been in use to treat alcoholism since the 1950s. There is now independent preclinical data that supports DSF as an anticancer agent, and experimental data suggest that copper may increase its anti-neoplastic properties. There is also some clinical evidence that DSF is a promising anticancer agent in extracranial cancers. In glioblastoma, DSF induced O 6 -methylguanine methyltransferase (MGMT) inhibition may incr...
Source
12345678910