Enrico Premi
University of Brescia
Publications 85
#1Massimo GambaH-Index: 9
#2Nicola GilbertiH-Index: 7
Last.Mauro MagoniH-Index: 13
view all 17 authors...
endovascular therapy (ET) is the standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The role of adjunctive intravenous thrombolysis (IVT) in these patients remains unclear. The present study aims to investigate whether IVT followed by ET (CoT, combined therapy) provides additional benefits over direct ET for anterior circulation AIS with LVO. we achieved a single center retrospective study of patients with AIS caused by anterior circulat...
#1Stefano Gazzina (University of Brescia)H-Index: 10
#2Mario Grassi (UNIPV: University of Pavia)H-Index: 30
Last.Barbara Borroni (University of Brescia)H-Index: 48
view all 33 authors...
Objective Cognitively engaging lifestyles have been associated with reduced risk of conversion to dementia. Multiple mechanisms have been advocated, including increased brain volumes (ie, brain reserve) and reduced disease progression (ie, brain maintenance). In cross-sectional studies of presymptomatic frontotemporal dementia (FTD), higher education has been related to increased grey matter volume. Here, we examine the effect of education on grey matter loss over time. Methods Two-hundred twent...
#1Andrea Pilotto (University of Brescia)H-Index: 15
#2Francesca Schiano di Cola (University of Brescia)H-Index: 1
Last.Alessandro Padovani (University of Brescia)H-Index: 62
view all 18 authors...
Purpose The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123I-FP-CIT SPECT imaging.
1 CitationsSource
#1Marta Manes (University of Brescia)H-Index: 5
#2Antonella Alberici (University of Brescia)H-Index: 27
Last.Barbara Borroni (University of Brescia)H-Index: 48
view all 17 authors...
Abstract Introduction Spinocerebellar Ataxia 38 (SCA38) is caused by ELOVL5 gene mutation, with significant reduction of serum docosahexaenoic acid (DHA) levels. DHA supplementation has been proven effective at short-term follow-up. In the present paper, we evaluated long-term safety and efficacy of 600 mg/day oral DHA in SCA38 by a 2-year open label extension study. Methods Nine SCA38 patients underwent standardised clinical assessment at 62 (T1), 82 (T2) and 104 (T3) weeks, and compared to pre...
#1Timothy Rittman (University of Cambridge)H-Index: 19
#2Robin J Borchert (University of Cambridge)H-Index: 4
Last.Miren ZulaicaH-Index: 2
view all 125 authors...
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
3 CitationsSource
#1Enrico Premi (University of Brescia)H-Index: 18
#2Vince D. Calhoun (UNM: University of New Mexico)H-Index: 93
Last.Miren ZulaicaH-Index: 2
view all 133 authors...
Abstract Frontotemporal Dementia (FTD) is preceded by a long period of subtle brain changes, occurring in the absence of overt cognitive symptoms, that need to be still fully characterized. Dynamic network analysis based on resting-state magnetic resonance imaging (rs-fMRI) is a potentially powerful tool for the study of preclinical FTD. In the present study, we employed a "chronnectome" approach (recurring, time-varying patterns of connectivity) to evaluate measures of dynamic connectivity in 4...
2 CitationsSource
#1Alberto Benussi (University of Brescia)H-Index: 11
#2Stefano Gazzina (University of Brescia)H-Index: 10
Last.Barbara Borroni (University of Brescia)H-Index: 48
view all 14 authors...
Abstract Presymptomatic carriers of GRN and C9orf72 mutations, the most frequent genetic causes of frontotemporal lobar degeneration, represent the optimal target population for the development of disease-modifying drugs. Preclinical biomarkers are needed to monitor the effect of therapeutic interventions in this population. We assessed clinical, functional, and neurophysiological measures in 113 GRN or C9orf72 carriers and in 73 noncarrier first-degree relatives. For 73 patients, follow-up long...
2 CitationsSource
#1Valentina Saba (UNIPV: University of Pavia)
#2Enrico Premi (University of Brescia)H-Index: 18
Last.Mario Grassi (UNIPV: University of Pavia)H-Index: 30
view all 10 authors...
Brain functional disruption and cognitive shortfalls as consequences of neurodegeneration are among the most investigated aspects in current clinical research. Traditionally, specific anatomical and behavioural traits have been associated with neurodegeneration, thus directly translatable in clinical terms. However, these qualitative traits, do not account for the extensive information flow breakdown within the functional brain network that deeply affect cognitive skills. Behavioural variant Fro...
#1Claire Cury (UCL: University College London)H-Index: 5
#2Stanley Durrleman (University of Paris)H-Index: 20
Last.Jason D. Warren (UCL Institute of Neurology)H-Index: 59
view all 64 authors...
Brain atrophy as measured from structural MR images, is one of the primary imaging biomarkers used to track neurodegenerative disease progression. In diseases such as frontotemporal dementia or Alzheimer's disease, atrophy can be observed in key brain structures years before any clinical symptoms are present. Atrophy is most commonly captured as volume change of key structures and the shape changes of these structures are typically not analysed despite being potentially more sensitive than summa...
2 CitationsSource
#1Franco Cauda (UNITO: University of Turin)H-Index: 29
#2Andrea Nani (UNITO: University of Turin)H-Index: 7
Last.Tommaso Costa (UNITO: University of Turin)H-Index: 15
view all 8 authors...
In the field of neuroimaging reverse inferences can lead us to suppose the involvement of cognitive processes from certain patterns of brain activity. Still, the same reasoning holds if we substitute 9brain activity9 with 9brain alteration9 and 9cognitive process9 with 9brain disorder9. To assess the involvement of a certain alteration pattern in a brain disorder we used the Bayes9 factor technique on voxel-based morphometry data of schizophrenia and Alzheimer9s disease. This technique allows to...