Timothy R. Wessel
University of Florida
CardiologyCoronary artery diseaseIschemiaDiabetes mellitusMedicine
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Publications 34
#1Gregory O. von Mering (UF: University of Florida)H-Index: 8
#2Bruce David JohnsonH-Index: 33
Last. Carl J. Pepine (UF: University of Florida)H-Index: 104
view all 12 authors...
Objective We investigated whether coronary microvascular dysfunction predicts major adverse outcomes during follow-up among women with signs and symptoms of ischemia.
314 CitationsSource
#1Christopher B. Arant (UF: University of Florida)H-Index: 14
#2Timothy R. Wessel (UF: University of Florida)H-Index: 14
Last. Carl J. Pepine (UF: University of Florida)H-Index: 104
view all 14 authors...
Background Inflammatory marker and hemoglobin levels (eg biomarkers) considered separately, predict adverse events in selected populations. Hypothesis A multiple biomarker approach predicts adverse events in women referred for evaluation of ischemia. Methods We investigated associations between biomarkers (high sensitivity C-reactive protein, interleukin-6, serum amyloid-A, and hemoglobin levels) with adverse outcomes in women referred for coronary angiography for suspected ischemia in the Natio...
18 CitationsSource
#1Timothy R. Wessel (UF: University of Florida)H-Index: 14
#2Christopher B. Arant (UF: University of Florida)H-Index: 14
Last. Carl J. Pepine (UF: University of Florida)H-Index: 104
view all 16 authors...
Background Altered coronary reactivity is frequent in women with findings of myocardial ischemia without significant obstructive disease. This suggests a defect in coronary microvascular function. The adenosine-related component of this altered reactivity has been described in male and mixed gender populations, while the factors influencing this component of coronary reactivity in symptomatic women have received limited attention. Accordingly, the relationship between adenosine-related microvasc...
47 CitationsSource
#1Amir LermanH-Index: 92
#2Arshed A. QuyyumiH-Index: 59
Last. Vera BittnerH-Index: 1
view all 17 authors...
1 Citations
#1Gregory J. WelderH-Index: 5
#2Timothy R. WesselH-Index: 14
Last. Issam ZinehH-Index: 24
view all 5 authors...
Study Objectives. To determine the frequency and type of complementary and alternative medicine (CAM) use among healthy volunteers participating in research, and to investigate the potential for interactions between commonly used CAM modalities and various drugs. Design. Prospective evaluation. Setting. University general clinical research center. Subjects. Sixty healthy adults participating in an ongoing drug study. Measurements and Main Results. The clinical study database was queried to deter...
14 CitationsSource
#1Issam Zineh (UF: University of Florida)H-Index: 24
#2Gregory J. Welder (UF: University of Florida)H-Index: 5
Last. Richard S. Schofield (UF: University of Florida)H-Index: 27
view all 6 authors...
Study Objectives. To investigate whether atorvastatin decreases serum or leukocyte-produced CD40 ligand (CD40L) levels and whether these effects are dependent on reduction in low-density lipoprotein cholesterol (LDL) levels in people without overt dyslipidemia. Design. Prospective pilot study. Setting. University research center. Subjects. Twenty-five normocholesterolemic volunteers (mean age 32 ± 11 yrs; 15 women, 10 men) without cardiovascular disease. Intervention. After a 2-week drug-free ru...
5 CitationsSource
#2B. Delia JohnsonH-Index: 38
Last. Carl J. PepineH-Index: 104
view all 12 authors...
Background Inflammatory markers and low hemoglobin (Hgb) levels predict adverse cardiovascular (CV) outcomes in selected populations. The evaluation of traditional risk predictors in this context i...
#1Issam ZinehH-Index: 24
#2Xiaoping LuoH-Index: 24
Last. Nasser CheginiH-Index: 44
view all 8 authors...
Study Objective. To investigate the immunomodulatory effects of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) by determining whether atorvastatin alters the production of specific endothelium-derived immunoactive proteins and whether its treatment effects depend on its concentration and/or inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Design. In vitro study using a multiplexing method for protein measurement. Setting. University laboratory. Measurements an...
24 CitationsSource
#1Issam Zineh (UF: University of Florida)H-Index: 24
#2Christina L. Aquilante (Anschutz Medical Campus)H-Index: 20
Last. Richard S. Schofield (UF: University of Florida)H-Index: 27
view all 7 authors...
Abstract Data exist linking elevated epithelial neutrophil activating peptide (ENA-78) concentrations with myriad inflammatory conditions. ENA-78 is encoded by the CXCL5 gene which has recently been shown to be polymorphic in nature (rs352046 and rs425535). No functional data on these polymorphisms exist. We investigated whether CXCL5 polymorphisms are associated with differences in plasma ENA-78 concentrations or leukocyte production of ENA-78 from cultured leukocytes in relatively healthy adul...
16 CitationsSource
#1Leslee J. Shaw (Cedars-Sinai Medical Center)H-Index: 110
#2C. Noel Bairey Merz (Cedars-Sinai Medical Center)H-Index: 71
Last. George SopkoH-Index: 80
view all 17 authors...
Despite a dramatic decline in mortality over the past three decades, coronary heart disease is the leading cause of death and disability in the U.S. Importantly, recent advances in the field of cardiovascular medicine have not led to significant declines in case fatality rates for women when compared to the dramatic declines realized for men. The current review highlights gender-specific issues in ischemic heart disease presentation, evaluation, and outcomes with a special focus on the results p...
503 CitationsSource