Susanna Sainio
Finnish Red Cross
Publications 9
#1Katri Haimila (Finnish Red Cross)H-Index: 19
#2Kati Sulin (Finnish Red Cross)H-Index: 2
Last.Susanna Sainio (Finnish Red Cross)H-Index: 5
view all 8 authors...
Introduction The aim of this study was to assess the accuracy of the non-invasive fetal RHD test at 24-26 weeks of gestation as part of the national antenatal screening programme to target routine antenatal anti-D prophylaxis (RAADP) at 28-30 weeks at women carrying an RhD-positive fetus Material and methods A prospective cohort study involving all maternity care centres and delivery hospitals in Finland between February 2014 and January 2016. Fetal RHD genotyping using cell-free fetal DNA in ma...
11 CitationsSource
#1Susanna Sainio (Finnish Red Cross)H-Index: 5
#2Kaija Javela (Finnish Red Cross)H-Index: 10
Last.Katri Haimila (Finnish Red Cross)H-Index: 19
view all 4 authors...
Summary Lack of reliable laboratory parameters is the main challenge in the management of fetal and neonatal alloimmune thrombocytopenia (FNAIT). Despite the long-known association between the HLA-DRB3*01:01 allele and human platelet antigen 1a (HPA-1a) alloimmunisation, maternal human leucocyte antigen (HLA) typing has been of little clinical value. Recently, other DRB3 allele variants have been suggested to predict the severity of FNAIT. In this nationwide population-based retrospective cohort...
4 CitationsSource
#1Myrthe E. Sonneveld (UvA: University of Amsterdam)H-Index: 4
#2Suvi Natunen (Finnish Red Cross)H-Index: 10
Last.Gestur Vidarsson (UvA: University of Amsterdam)H-Index: 31
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Fetal or neonatal alloimmune thrombocytopenia (FNAIT) is a potentially life-threatening disease where fetal platelets are destroyed by maternal anti-platelet IgG alloantibodies. The clinical outcome varies from asymptomatic, to petechiae or intracranial haemorrhage, but no marker has shown reliable correlation with severity, making screening for FNAIT impractical and highly inefficient. We recently found IgG Fc-glycosylation towards platelet and red blood cell antigens to be skewed towards decre...
28 CitationsSource
#1Susanna Sainio (Finnish Red Cross)H-Index: 5
#2Irmeli Nupponen (UH: University of Helsinki)H-Index: 11
Last.Vedran Stefanovic (HYKS: Helsinki University Central Hospital)H-Index: 12
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Objective Outcome after intrauterine transfusions due to severe hemolytic disease of the fetus and newborn. Design Nationwide population-based retrospective cohort study. Setting All women treated with intrauterine transfusions for hemolytic disease of the fetus and newborn in Finland in 2003–2012. Population 339 intrauterine transfusions, performed in 104 pregnancies of 84 women. Methods Information on antenatal screening of red cell antibodies and red cell units issued for intrauterine transfu...
9 CitationsSource
#1Riina JernmanH-Index: 1
#2Anu KorhonenH-Index: 2
Last.Susanna SainioH-Index: 5
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2 Citations
A rare blood group and the associated anti-red cell antibody against a very common blood group factor make it significantly more difficult to find suitable red cell products, possibly endangering the additional treatment of the patient. The need of rare blood should be anticipated early enough. The availability of red cells is secured by extensive blood group studies among blood donors, by donor registers, freezing of rare red cells and through international collaboration. The determination of r...
#1Eeva Juvonen (Finnish Red Cross)H-Index: 28
#2Inna Sareneva (Finnish Red Cross)H-Index: 2
Last.Susanna Sainio (Finnish Red Cross)H-Index: 5
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The Finnish Red Cross Blood Service performs blood grouping of all blood donations in Finland and serves as a national reference laboratory in pre-transfusion testing of patients. In addition to ABO and RhD blood groups, other Rh antigens and K antigen are also determined from all red cell units. The antigens of JK, FY, and MNS blood group systems are analyzed from selected donors. The extensive donor typing procedure includes antigens from KEL, LW, LU, CO, DO, DI, YT, GE and CROM blood group sy...
#1Susanna Sainio (Finnish Red Cross)H-Index: 5
#2Kaija Javela (Finnish Red Cross)H-Index: 10
Last.Sinikka Koskinen (Finnish Red Cross)H-Index: 10
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Summary Objective To study the clinical usefulness of maternal anti-HPA-1a antibody levels in predicting severe foetomaternal alloimmune thrombocytopenia (FMAIT). Background Recent studies using an international anti-HPA-1a standard have shown a correlation between maternal antibody levels and neonatal thrombocytopenia. Cut-off values for identifying high-risk pregnancies have also been suggested. Materials In 1986–2010, HPA-1a alloimmunisation was confirmed in 84 women with 129 pregnancies. Mat...
8 CitationsSource
#1Heidi TillerH-Index: 7
#2Marije M. Kamphuis (LUMC: Leiden University Medical Center)H-Index: 7
Last.Magnus Westgren (KI: Karolinska Institutet)H-Index: 39
view all 14 authors...
Objective To characterise pregnancies where the fetus or neonate was diagnosed with fetal and neonatal alloimmune thrombocytopenia (FNAIT) and suffered from intracranial haemorrhage (ICH), with special focus on time of bleeding onset. Design Observational cohort study of all recorded cases of ICH caused by FNAIT from the international No IntraCranial Haemorrhage (NOICH) registry during the period 2001–2010. Setting 13 tertiary referral centres from nine countries across the world. Participants 3...
50 CitationsSource