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Jason D. Whittle
University of South Australia
Plasma polymerizationOrganic chemistryChemistryPolymerPlasma
60Publications
19H-index
1,200Citations
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Publications 55
Newest
#1Zahra Sadrearhami (UNSW: University of New South Wales)H-Index: 6
#2Rashin Namivandi-Zangeneh (UNSW: University of New South Wales)H-Index: 3
Last. Cyrille Boyer (UNSW: University of New South Wales)H-Index: 69
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The development of novel strategies for the prevention of bacterial infections is of utmost importance because of the exponential growth in the number of patient morbidity related to nosocomial and chronic infections. Nitric oxide (NO) is known to be a potent inhibitor of bacterial growth and adhesion to surfaces. Here, we develop an antibiofilm coating that possesses S-nitrosothiol NO donors via plasma polymerization (PP) for biofilm prevention applications. Cell culture dishes of four differen...
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#1Sameer A. Al-Bataineh (UniSA: University of South Australia)H-Index: 16
#2Alex Cavallaro (UniSA: University of South Australia)H-Index: 15
Last. Krasimir Vasilev (UniSA: University of South Australia)H-Index: 40
view all 6 authors...
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#1Sameer A. Al-Bataineh (UniSA: University of South Australia)H-Index: 16
#2Alex Cavallaro (UniSA: University of South Australia)H-Index: 15
Last. Krasimir Vasilev (UniSA: University of South Australia)H-Index: 40
view all 6 authors...
1 CitationsSource
Plant metabolites that have shown activity against bacteria and/or environmental fungi represent valuable leads for the identification and development of novel drugs against clinically important human pathogenic fungi. Plants from the genus Eremophila were highly valued in traditional Australian Aboriginal medicinal practices, and E. alternifolia was the most prized among them. As antibacterial activity of extracts from E. alternifolia has been documented, this study addresses the question wheth...
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#1Lynn Yap (Agency for Science, Technology and Research)H-Index: 4
#2Sadasivam Murali (Agency for Science, Technology and Research)H-Index: 14
Last. Simon M. Cool (Agency for Science, Technology and Research)H-Index: 42
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Functionalizing medical devices with polypeptides to enhance their performance has become important for improved clinical success. The extracellular matrix (ECM) adhesion protein vitronectin (VN) is an effective coating, although the chemistry used to attach VN often reduces its bioactivity. In vivo, VN binds the ECM in a sequence-dependent manner with heparan sulfate (HS) glycosaminoglycans. We reasoned therefore that sequence-based affinity chromatography could be used to isolate a VN-binding ...
2 CitationsSource
#1Giles T. S. Kirby (UniSA: University of South Australia)H-Index: 9
#2Andrew Michelmore (UniSA: University of South Australia)H-Index: 26
Last. Robert D. Short (Lancaster University)H-Index: 46
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This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing biological substrates. Synthetic surfaces provide a far more versatile system for culturing and delivering cell sheets. This has the potential to positiv...
7 CitationsSource
#1Hanieh Safizadeh Shirazi (UniSA: University of South Australia)H-Index: 3
#2Nicholas Rogers (UniSA: University of South Australia)H-Index: 1
Last. Jason D. Whittle (UniSA: University of South Australia)H-Index: 19
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Abstract Human Mesenchymal Stem cells (hMSCs) are becoming a major focus in biomedical fields. Application of in vitro expanded hMSCs to treat numerous ailments has led to a commercial emphasis on improving hMSC growth ex vivo. Production of substrate independent, novel thin films is one potential tool for production of commercial viable hMSC expansion. Plasma polymerization allow controlled chemical optimisation of large scale surface areas in a substrate independent manner. Previous study show...
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#2Andrew MichelmoreH-Index: 26
Last. Krasimir VasilevH-Index: 40
view all 5 authors...
Plasma deposited polyoxazoline thin films share many valuable properties with polyoxazoline prepared via conventional organic chemistry; they are biocompatible, non-cytotoxic and low fouling. What is more, they bind biomolecules covalently, support cell adhesion, and are generated in a solvent free, single step process. Here, we show that the secret for plasma deposited polyoxazolines’ unique set of properties lies in both the chemical fragmentation processes occurring in the plasma phase itself...
6 CitationsSource
#1Solmaz Saboohi (UniSA: University of South Australia)H-Index: 5
#2Sameer A. Al-Bataineh (UniSA: University of South Australia)H-Index: 16
Last. Jason D. Whittle (UniSA: University of South Australia)H-Index: 19
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The plasma phase of furfuryl methacrylate (FMA) and its relationship to the surface chemistry of the generated plasma coatings was investigated utilizing mass spectrometry. Positive ion mass spectra from plasma phase and plasma coatings of FMA revealed that furanylmethyl fragment (FM, 81 m/z) has high stability and form oligomers with itself and other species in the plasma phase and on the surface. Combined with ion flux and deposition rate data, the correlation between the normalized intensitie...
4 CitationsSource
#1Andrew MichelmoreH-Index: 26
#2Jason D. WhittleH-Index: 19
Last. Robert D. ShortH-Index: 46
view all 3 authors...
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