Katherine M. Bever
Johns Hopkins University
EnzymeSirtuinBiochemistryDNA mismatch repairNAD+ kinase
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Publications 10
#1Katherine M. Bever (Johns Hopkins University)H-Index: 5
#2Erkut Borazanci (TGen: Translational Genomics Research Institute)H-Index: 10
Last. Annie A. Wu (Johns Hopkins University)H-Index: 6
view all 21 authors...
#1Katherine M. Bever (Johns Hopkins University)H-Index: 5
#2Erkut BorazanciH-Index: 10
Last. Ana De Jesus-Acosta (Johns Hopkins University)H-Index: 12
view all 18 authors...
700Background: Few studies have examined maintenance therapy in unselected pts with metastatic PDA (mPDA). mTOR signaling is central to several oncogenic pathways in PDA and also has a role in T ce...
#1Katherine M. Bever (Johns Hopkins University)H-Index: 5
#2Hao Wang (Johns Hopkins University)H-Index: 47
Last. Robert A. Anders (Johns Hopkins University)H-Index: 58
view all 14 authors...
TPS839Background: Cancers deficient in DNA mismatch repair (dMMR) are highly immunogenic tumors exhibiting high rates of response to immune checkpoint inhibitors targeting the programmed cell death...
#1Dung T. Le (Johns Hopkins University)H-Index: 36
#2Jennifer N. Durham (Johns Hopkins University)H-Index: 6
Last. Luis A. Diaz (Johns Hopkins University)H-Index: 95
view all 46 authors...
The genomes of cancers deficient in mismatch repair contain exceptionally high numbers of somatic mutations. In a proof-of-concept study, we previously showed that colorectal cancers with mismatch repair deficiency were sensitive to immune checkpoint blockade with antibodies to programmed death receptor–1 (PD-1). We have now expanded this study to evaluate the efficacy of PD-1 blockade in patients with advanced mismatch repair–deficient cancers across 12 different tumor types. Objective radiogra...
995 CitationsSource
#1Dung T. LeH-Index: 36
#2Jennifer N. DurhamH-Index: 6
view all 43 authors...
#1Katherine M. Bever (Johns Hopkins University)H-Index: 5
#2Elizabeth A. SugarH-Index: 32
Last. Lei ZhengH-Index: 30
view all 10 authors...
Background Pancreatic ductal adenocarcinoma (PDA) is comprised of a prominent desmoplastic stromal compartment and only 10–40% of the tumour consists of PDA cells. However, how stromal components should be assessed and how the characteristics of the stromal compartment determine clinical outcomes in PDA patients remain unknown.
25 CitationsSource
#1Elaine O. Bigelow (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
#1Elaine Bigelow (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 5
Last. Lei ZhengH-Index: 7
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B7-H1/PD-L1, a member of the B7 family of immune-regulatory cell-surface proteins, plays an important role in the negative regulation of cell-mediated immune responses through its interaction with its receptor, programmed death-1 (PD-1) 1,2. Overexpression of B7-H1 by tumor cells has been noted in a number of human cancers, including melanoma, glioblastoma, and carcinomas of the lung, breast, colon, ovary, and renal cells, and has been shown to impair anti-tumor T-cell immunity3-8. Recently, B7-...
34 CitationsSource
#1Michael S. CosgroveH-Index: 17
Last. Cynthia WolbergerH-Index: 47
view all 6 authors...
1 CitationsSource
#1Michael S. Cosgrove (SU: Syracuse University)H-Index: 17
#2Katherine M. Bever (Johns Hopkins University)H-Index: 5
Last. Cynthia WolbergerH-Index: 47
view all 6 authors...
Sirtuins comprise a family of enzymes that catalyze the deacetylation of acetyllysine side chains in a reaction that consumes NAD+. Although several crystal structures of sirtuins bound to non-native acetyl peptides have been determined, relatively little about how sirtuins discriminate among different substrates is understood. We have carried out a systematic structural and thermodynamic analysis of several peptides bound to a single sirtuin, the Sir2 homologue from Thermatoga maritima (Sir2Tm)...
75 CitationsSource
#1José L. Avalos (HHMI: Howard Hughes Medical Institute)H-Index: 16
#2Katherine M. Bever (HHMI: Howard Hughes Medical Institute)H-Index: 5
Last. Cynthia Wolberger (HHMI: Howard Hughes Medical Institute)H-Index: 47
view all 3 authors...
Summary Sir2 enzymes form a unique class of NAD + -dependent deacetylases required for diverse biological processes, including transcriptional silencing, regulation of apoptosis, fat mobilization, and lifespan regulation. Sir2 activity is regulated by nicotinamide, a noncompetitive inhibitor that promotes a base-exchange reaction at the expense of deacetylation. To elucidate the mechanism of nicotinamide inhibition, we determined ternary complex structures of Sir2 enzymes containing nicotinamide...
288 CitationsSource