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Timothy Rittman
University of Cambridge
PsychologyNeuroscienceCognitionParkinson's diseaseMedicine
55Publications
19H-index
1,079Citations
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Publications 57
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#1Fraser S. Brown (University of Cambridge)
Last. Timothy RittmanH-Index: 19
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#1Audrey Low (University of Cambridge)H-Index: 1
#2Elijah Mak (University of Cambridge)H-Index: 17
Last. John T. O'Brien (University of Cambridge)H-Index: 101
view all 14 authors...
Abstract Introduction Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear. Methods Lateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amyloid-positive patients with mild cognitive impairment, and 18 patients with AD dementia). We compared lateralization indices across diagnostic groups and correlated them with cl...
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#1Maura Malpetti (University of Cambridge)
#2Rogier A. KievitH-Index: 23
Last. James B. Rowe (University of Cambridge)H-Index: 57
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Tau pathology, neuroinflammation, and neurodegeneration are key aspects of Alzheimer9s disease. Understanding whether these features predict cognitive decline, alone or in combination, is crucial to develop new prognostic measures and enhanced stratification for clinical trials. Here, we studied how baseline assessments of in vivo tau pathology (measured by [18F]AV-1451 PET), neuroinflammation (indexed via [11C]PK11195 PET) and brain atrophy (derived from structural MRI) predicted longitudinal c...
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#1Maura Malpetti (University of Cambridge)
#2Luca Passamonti (University of Cambridge)H-Index: 28
Last. James B. Rowe (University of Cambridge)H-Index: 57
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Background: Progressive Supranuclear Palsy (PSP) is associated with tau-protein aggregation and neuroinflammation, but it remains unclear whether these pathogenic processes are related in vivo. Objectives: We examined the relationship between tau pathology and microglial activation using [18F]AV-1451 (indexing tau burden) and [11C]PK11195 (microglial activation) PET in n=17 patients with PSP-Richardson9s syndrome. Methods: Non-displaceable binding potential (BPND) for each ligand was quantified ...
1 CitationsSource
#1Marta M. Correia (Cognition and Brain Sciences Unit)H-Index: 13
#2Timothy Rittman (University of Cambridge)H-Index: 19
Last. James B. Rowe (University of Cambridge)H-Index: 57
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The early and accurate differential diagnosis of parkinsonian disorders is still a significant challenge for clinicians. In recent years, a number of studies have used MRI data combined with machine learning and statistical classifiers to successfully differentiate between different forms of Parkinsonism. However, several questions and methodological issues remain, to minimise bias and artefact-driven classification. In this study we compared different approaches for feature selection, as well a...
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#1Jeremy M BrownH-Index: 7
#1Jeremy BrownH-Index: 13
Last. James B. RoweH-Index: 57
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This paper summarises the current status of two novel short cognitive tests (SCT), known as Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI). The history of and recent research on the TYM and TYM-MCI are summarised in applications for Alzheimer’s and non-Alzheimer’s dementia and mild cognitive impairment. The TYM test can be used in a general neurology clinic and can help distinguish patients with Alzheimer’s disease (AD) from those with no neurological cause f...
1 CitationsSource
#1Jeremy BrownH-Index: 13
#2Julie Wiggins (University of Cambridge)H-Index: 3
Last. James B. Rowe (University of Cambridge)H-Index: 57
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Background/aims To validate the use of the Test Your Memory (TYM) test in dementias other than Alzheimer’s disease, and to compare the TYM test to two other short cognitive tests.
1 CitationsSource
#2Luca PassamontiH-Index: 28
Last. James B. RoweH-Index: 57
view all 14 authors...
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#1Audrey LowH-Index: 1
#2Elijah MakH-Index: 17
Last. John T. O'BrienH-Index: 101
view all 14 authors...
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