Timothy Rittman
University of Cambridge
Publications 55
#1Audrey Low (University of Cambridge)H-Index: 1
#2Elijah Mak (University of Cambridge)H-Index: 17
Last.John T. O'Brien (University of Cambridge)H-Index: 101
view all 14 authors...
Abstract Introduction Although widespread cortical asymmetries have been identified in Alzheimer's disease (AD), thalamic asymmetries and their relevance to clinical severity in AD remain unclear. Methods Lateralization indices were computed for individual thalamic subnuclei of 65 participants (33 healthy controls, 14 amyloid-positive patients with mild cognitive impairment, and 18 patients with AD dementia). We compared lateralization indices across diagnostic groups and correlated them with cl...
#1Jeremy BrownH-Index: 13
#2Julie Wiggins (University of Cambridge)H-Index: 3
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 6 authors...
Background/aims To validate the use of the Test Your Memory (TYM) test in dementias other than Alzheimer’s disease, and to compare the TYM test to two other short cognitive tests.
1 CitationsSource
#1Marta M. Correia (Cognition and Brain Sciences Unit)H-Index: 13
#2Timothy Rittman (University of Cambridge)H-Index: 19
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 7 authors...
The early and accurate differential diagnosis of parkinsonian disorders is still a significant challenge for clinicians. In recent years, a number of studies have used MRI data combined with machine learning and statistical classifiers to successfully differentiate between different forms of Parkinsonism. However, several questions and methodological issues remain, to minimise bias and artefact-driven classification. In this study we compared different approaches for feature selection, as well a...
#1Jeremy M BrownH-Index: 7
#2Julie WigginsH-Index: 3
Last.James B. RoweH-Index: 57
view all 5 authors...
This paper summarises the current status of two novel short cognitive tests (SCT), known as Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI). The history of and recent research on the TYM and TYM-MCI are summarised in applications for Alzheimer’s and non-Alzheimer’s dementia and mild cognitive impairment. The TYM test can be used in a general neurology clinic and can help distinguish patients with Alzheimer’s disease (AD) from those with no neurological cause f...
#1Audrey LowH-Index: 1
#2Elijah MakH-Index: 17
Last.John T. O'BrienH-Index: 101
view all 14 authors...
#1Timothy Rittman (University of Cambridge)H-Index: 19
#2Robin J Borchert (University of Cambridge)H-Index: 4
Last.Miren ZulaicaH-Index: 2
view all 125 authors...
The presymptomatic phase of neurodegenerative diseases are characterized by structural brain changes without significant clinical features. We set out to investigate the contribution of functional network resilience to preserved cognition in presymptomatic genetic frontotemporal dementia. We studied 172 people from families carrying genetic abnormalities in C9orf72, MAPT, or PGRN. Networks were extracted from functional MRI data and assessed using graph theoretical analysis. We found that despit...
3 CitationsSource
#1Timothy E. HamH-Index: 15
#2Timothy RittmanH-Index: 19
In this chapter we look at how to approach the neurological assessment of a person with a brain tumour. We discuss the symptoms they may present with, in particular cognitive impairment, headache and seizures. We introduce the neurological examination of motor function, eyes and cognition, concentrating on the most useful aspects of these assessments for patients with a brain tumour.
#1Robin J Borchert (University of Cambridge)H-Index: 4
#2Timothy Rittman (University of Cambridge)H-Index: 19
Last.James B. Rowe (University of Cambridge)H-Index: 57
view all 12 authors...
Parkinson’s disease has multiple detrimental effects on motor and cognitive systems in the brain. In contrast to motor deficits, cognitive impairments in Parkinson’s disease are usually not ameliorated, and can even be worsened, by dopaminergic treatments. Recent evidence has shown potential benefits from restoring other neurotransmitter deficits, including noradrenergic and serotonergic transmission. Here, we study global and regional brain network organization using task-free imaging (also kno...