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Martin A. Birchall
University College London
277Publications
35H-index
5,608Citations
Publications 277
Newest
#1Linxiao Wu (UCL: University College London)H-Index: 2
#2Adrián Magaz (UCL: University College London)H-Index: 3
Last.Mark Emberton (UCL: University College London)H-Index: 63
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#1Martin A. BirchallH-Index: 35
#2Peggy Herrmann (UCL Ear Institute)
Last.Paul SibbonsH-Index: 17
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Abstract Background Loss of substantial volumes of laryngeal tissue after trauma or cancer significantly impairs quality of life. We hypothesised that repair of laryngeal defects with a candidate biomaterial, seeded with mesenchymal stem cells (MSC) and epithelial cells, may offer a therapeutic approach to this unmet need. Method Moulded porous polyhedral oligomeric silsesquioxane polycarbonate-urea (POSS-PCU) scaffolds were seeded with human-derived MSC and epithelial cells, were implanted orth...
#1Olumide Ogunlade (UCL: University College London)H-Index: 7
#2Jasmine Oy Ho (UCL: University College London)H-Index: 1
Last.Paul C. Beard (UCL: University College London)H-Index: 36
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Abstract Tissue engineering is a branch of regenerative medicine that aims to manipulate cells and scaffolds to create bioartificial tissues and organs for patients. A major challenge lies in monitoring the blood supply to the new tissue following transplantation: the integration and neovascularization of scaffolds in vivo is critical to their functionality. Photoacoustic imaging (PAI) is a laser-generated ultrasound-based technique that is particularly well suited to visualising microvasculatur...
#2Robert E. HyndsH-Index: 10
Last.Sam M. JanesH-Index: 40
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Airway epithelial cells are a key barrier to inhaled toxicants, pollutants and infectious agents. During severe epithelial injury and in transplantation settings, it would be desirable to rapidly reintroduce a functional epithelium through the engraftment of exogenous cells or by promoting host regeneration. However, the three-dimensional surface of the airway and the requirement to maintain airflow using stents, which cause mechanical shear at the tracheal surface, are challenges. Here, we inve...
#1Linxiao Wu (UCL: University College London)H-Index: 2
#2Adrián Magaz (UCL: University College London)H-Index: 3
Last.Wenhui Song (UCL: University College London)H-Index: 17
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Abstract This DiB article contains data related to the research article entitled “Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS” (Wu et al., 2018). Thermoresponsive poly (urea-urethane) nanohybrid elastomer (PUU-POSS) scaffolds were implanted in rats for up to 3 months. The porous structure and tensile mechanical properties of the scaffolds are listed and compared before and after in vitro and in vivo tests. The details of the histological anal...
Objective To modify the non-porous surface membrane of a tissue-engineered laryngeal scaffold to allow effective cell entry. Methods The mechanical properties, surface topography and chemistry of polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane were characterised. A laser technique introduced surface perforations. Micro computed tomography generated porosity data. Scaffolds were seeded with cells, investigated histologically and proliferation studied. Incubation and time effect...
#1Linxiao Wu (UCL: University College London)H-Index: 2
#2Adrián Magaz (UCL: University College London)H-Index: 3
Last.Wenhui Song (UCL: University College London)H-Index: 17
view all 9 authors...
Abstract Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive ‘stiffness memory’ elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermally-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffnes...
#1J I HamiltonNick (UCL: University College London)H-Index: 1
#2E HyndsRobert (UCL: University College London)
Last.M JanesSam (UCL: University College London)
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Airway epithelial cells are a key barrier to inhaled toxicants, pollutants, and infectious agents. During severe epithelial injury and in transplantation settings, it would be desirable to rapidly ...
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