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Martin A. Birchall
University College London
277Publications
35H-index
5,608Citations
Publications 277
Newest
Published on May 1, 2019in Advanced Healthcare Materials 5.61
Linxiao Wu2
Estimated H-index: 2
(University College London),
Adrián Magaz3
Estimated H-index: 3
(University College London)
+ 9 AuthorsMark Emberton63
Estimated H-index: 63
(University College London)
1 Citations Source Cite
Published on Apr 26, 2019in Clinical Otolaryngology 2.70
Martin A. Birchall35
Estimated H-index: 35
(University College London),
Paul Carding28
Estimated H-index: 28
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Published on Mar 25, 2019in bioRxiv
Martin A. Birchall35
Estimated H-index: 35
,
Peggy Herrmann (UCL Ear Institute), Paul Sibbons17
Estimated H-index: 17
Abstract Background Loss of substantial volumes of laryngeal tissue after trauma or cancer significantly impairs quality of life. We hypothesised that repair of laryngeal defects with a candidate biomaterial, seeded with mesenchymal stem cells (MSC) and epithelial cells, may offer a therapeutic approach to this unmet need. Method Moulded porous polyhedral oligomeric silsesquioxane polycarbonate-urea (POSS-PCU) scaffolds were seeded with human-derived MSC and epithelial cells, were implanted orth...
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Published on Mar 1, 2019in Photoacoustics
Olumide Ogunlade7
Estimated H-index: 7
(University College London),
Jasmine Oy Ho1
Estimated H-index: 1
(University College London)
+ 6 AuthorsPaul C. Beard36
Estimated H-index: 36
(University College London)
Abstract Tissue engineering is a branch of regenerative medicine that aims to manipulate cells and scaffolds to create bioartificial tissues and organs for patients. A major challenge lies in monitoring the blood supply to the new tissue following transplantation: the integration and neovascularization of scaffolds in vivo is critical to their functionality. Photoacoustic imaging (PAI) is a laser-generated ultrasound-based technique that is particularly well suited to visualising microvasculatur...
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Published on Feb 1, 2019in Data in Brief
Linxiao Wu2
Estimated H-index: 2
(University College London),
Adrián Magaz3
Estimated H-index: 3
(University College London)
+ 6 AuthorsWenhui Song17
Estimated H-index: 17
(University College London)
Abstract This DiB article contains data related to the research article entitled “Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS” (Wu et al., 2018). Thermoresponsive poly (urea-urethane) nanohybrid elastomer (PUU-POSS) scaffolds were implanted in rats for up to 3 months. The porous structure and tensile mechanical properties of the scaffolds are listed and compared before and after in vitro and in vivo tests. The details of the histological anal...
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Published on Feb 1, 2019in Journal of Laryngology and Otology 0.97
K. Wismayer , Nazia Mehrban8
Estimated H-index: 8
+ 1 AuthorsMartin A. Birchall35
Estimated H-index: 35
Objective To modify the non-porous surface membrane of a tissue-engineered laryngeal scaffold to allow effective cell entry. Methods The mechanical properties, surface topography and chemistry of polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane were characterised. A laser technique introduced surface perforations. Micro computed tomography generated porosity data. Scaffolds were seeded with cells, investigated histologically and proliferation studied. Incubation and time effect...
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Published on Feb 1, 2019in Acta Biomaterialia 6.38
Linxiao Wu2
Estimated H-index: 2
(University College London),
Adrián Magaz3
Estimated H-index: 3
(University College London)
+ 6 AuthorsWenhui Song17
Estimated H-index: 17
(University College London)
Abstract Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive ‘stiffness memory’ elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermally-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffnes...
2 Citations Source Cite
Published on Feb 1, 2019in Tissue Engineering Part C-methods
J I HamiltonNick1
Estimated H-index: 1
(University College London),
E HyndsRobert (University College London)+ 7 AuthorsM JanesSam (University College London)
Airway epithelial cells are a key barrier to inhaled toxicants, pollutants, and infectious agents. During severe epithelial injury and in transplantation settings, it would be desirable to rapidly reintroduce a functional epithelium through the engraftment of exogenous cells or by promoting host regeneration. However, the three-dimensional surface of the airway and the requirement to maintain airflow using stents, which cause mechanical shear at the tracheal surface, are challenges. In this stud...
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