Martin A. Birchall
UCL Ear Institute
258Publications
33H-index
5,482Citations
Publications 258
Newest
Published on Mar 25, 2019in bioRxiv
Martin A. Birchall33
Estimated H-index: 33
(UCL Ear Institute),
Peggy Hermann (UCL Ear Institute), Paul Sibbons16
Estimated H-index: 16
Background: Loss of substantial volumes of laryngeal tissue after trauma or cancer significantly impairs quality of life. We hypothesised that repair of laryngeal defects with a candidate biomaterial, seeded with mesenchymal stem cells (MSC) and epithelial cells, may offer a therapeutic approach to this unmet need. Method: Moulded porous polyhedral oligomeric silsesquioxane polycarbonate-urea (POSS-PCU) scaffolds were seeded with human-derived MSC and epithelial cells, were implanted orthotopica...
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Published on Feb 1, 2019in Acta Biomaterialia 6.38
Linxiao Wu2
Estimated H-index: 2
(University College London),
Adrián Magaz2
Estimated H-index: 2
(University College London)
+ 6 AuthorsWenhui Song2
Estimated H-index: 2
(University College London)
Abstract Increasing evidence suggests the contribution of the dynamic mechanical properties of the extracellular matrix (ECM) to regulate tissue remodeling and regeneration. Following our recent study on a family of thermoresponsive ‘stiffness memory’ elastomeric nanohybrid scaffolds manufactured via an indirect 3D printing guided thermally-induced phase separation process (3D-TIPS), this work reports in vitro and in vivo cellular responses towards these scaffolds with different initial stiffnes...
1 Citations Source Cite
Published on Feb 1, 2019in Journal of Laryngology and Otology 0.97
K. Wismayer , N. Mehrban + 1 AuthorsMartin A. Birchall33
Estimated H-index: 33
Objective To modify the non-porous surface membrane of a tissue-engineered laryngeal scaffold to allow effective cell entry. Methods The mechanical properties, surface topography and chemistry of polyhedral oligomeric silsesquioxane poly(carbonate-urea) urethane were characterised. A laser technique introduced surface perforations. Micro computed tomography generated porosity data. Scaffolds were seeded with cells, investigated histologically and proliferation studied. Incubation and time effect...
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Published on Mar 1, 2019in Photoacoustics
Olumide Ogunlade7
Estimated H-index: 7
(University College London),
Jasmine Oy Ho1
Estimated H-index: 1
(University College London)
+ 6 AuthorsPaul C. Beard35
Estimated H-index: 35
(University College London)
Abstract Tissue engineering is a branch of regenerative medicine that aims to manipulate cells and scaffolds to create bioartificial tissues and organs for patients. A major challenge lies in monitoring the blood supply to the new tissue following transplantation: the integration and neovascularization of scaffolds in vivo is critical to their functionality. Photoacoustic imaging (PAI) is a laser-generated ultrasound-based technique that is particularly well suited to visualising microvasculatur...
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Published on Feb 1, 2019in Data in Brief
Linxiao Wu2
Estimated H-index: 2
(University College London),
Adrián Magaz2
Estimated H-index: 2
(University College London)
+ 6 AuthorsWenhui Song2
Estimated H-index: 2
(University College London)
Abstract This DiB article contains data related to the research article entitled “Cellular responses to thermoresponsive stiffness memory elastomer nanohybrid scaffolds by 3D-TIPS” (Wu et al., 2018). Thermoresponsive poly (urea-urethane) nanohybrid elastomer (PUU-POSS) scaffolds were implanted in rats for up to 3 months. The porous structure and tensile mechanical properties of the scaffolds are listed and compared before and after in vitro and in vivo tests. The details of the histological anal...
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Published on Mar 4, 2019in Clinical Otolaryngology 2.70
Martin A. Birchall33
Estimated H-index: 33
(University College London),
Paul Carding28
Estimated H-index: 28
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Matt Lechner4
Estimated H-index: 4
(University College London),
Liam Sutton1
Estimated H-index: 1
(University College London)
+ 7 AuthorsJohn S. Rubin10
Estimated H-index: 10
(University College London)
Importance Self-contained underwater breathing apparatus (scuba) diving has become increasingly popular with millions of people diving each year. Otorhinolaryngologists are often consulted either by patients or diving physicians regarding fitness to dive, and at present, the guidelines do not provide comprehensive information regarding the evaluation of this patient cohort. The aim of this review is to provide a comprehensive overview of existing otorhinolaryngological guidelines for fitness to ...
2 Citations Source Cite
Matt Lechner4
Estimated H-index: 4
(University College London),
Liam Sutton1
Estimated H-index: 1
(University College London)
+ 7 AuthorsJohn S. Rubin10
Estimated H-index: 10
(University College London)
Importance Scuba diving is becoming increasingly popular. However, scuba diving is associated with specific risks; 80% of adults and 85% of juvenile divers (aged 6-17 years) have been reputed to have an ear, nose, or throat complaint related to diving at some point during their diving career. Divers frequently seek advice from primary care physicians, diving physicians, and otorhinolaryngologists, not only in the acute setting, but also related to the long-term effects of diving. Observations Th...
1 Citations Source Cite
Published on Apr 1, 2018in Clinical Otolaryngology 2.70
M.S. Banus (University College London), Martin A. Birchall33
Estimated H-index: 33
(University College London),
J.A. Graveston (University College London)
Objective This prospective cohort study investigates the prediction of a voluntary cough using surface electromyography (EMG) of intercostal and diaphragm muscles, in order to develop control algorithms for an EMG controlled artificial larynx. Setting The Ear Institute, London. Main outcome measures EMG onset compared to voluntary cough exhalation onset and to 100ms (to give the artificial larynx the time to close the bioengineered vocal cords) before voluntary cough exhalation onset, in twelve ...
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Kate Gowers8
Estimated H-index: 8
(University College London),
Robert E. Hynds7
Estimated H-index: 7
(University College London)
+ 3 AuthorsSam M. Janes40
Estimated H-index: 40
(University College London)
Autologous airway epithelial cells have been used in clinical tissue-engineered airway transplantation procedures with a view to assisting mucosal regeneration and restoring mucociliary escalator function. However, limited time is available for epithelial cell expansion due to the urgent nature of these interventions and slow epithelial regeneration has been observed in patients. Human airway epithelial cells can be expanded from small biopsies or brushings taken during bronchoscopy procedures b...
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