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David J. Belton
Nottingham Trent University
31Publications
14H-index
868Citations
Publications 31
Newest
Published on May 1, 2019in NFS Journal
Graham J. Hickman3
Estimated H-index: 3
,
David J. Belton14
Estimated H-index: 14
+ 1 AuthorsCarole C. Perry44
Estimated H-index: 44
There is an increasing demand for environmentally sustainable sourcing of ingredients for the food, pharmaceutical and supplements industries. In the case of calcium carbonate (E170) as by-products from the egg and shellfish processing industries these have the potential to be sustainably sourced. In addition to their green credentials, biogenic carbonates have intrinsic benefits in terms of their chemical composition, such as a low heavy metal burden. However, their biogenic origin can potentia...
David J. Belton14
Estimated H-index: 14
(NTU: Nottingham Trent University),
Graham J. Hickman3
Estimated H-index: 3
(NTU: Nottingham Trent University),
Carole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
ABSTRACTCalcium carbonate (E170) is a common food and pharmaceutical additive/ingredient. In addition to a source of calcium, the carbonate has uses including as a colour, acidity regulator and bulking agent. Globally, a range of regulatory agencies and pharmacopoeia control the analyses and specification of additives in food, supplements, pharmaceutical substances and excipients. Accordingly, a range of specifications and analyses exist for calcium carbonate depending on the application and mar...
Published on Dec 1, 2018in Scientific Reports 4.01
Dv Scholey4
Estimated H-index: 4
(NTU: Nottingham Trent University),
David J. Belton14
Estimated H-index: 14
(NTU: Nottingham Trent University)
+ 1 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
In this study, we assessed uptake and potential efficacy of a novel, pH neutral form of silicon supplement in vitro and using broiler chickens as a model species. In vitro bioavailability of this supplement was significantly higher than other commercial supplements tested, all of which claim available silica content. To confirm bioavailability of the new supplement in vivo, a broiler chick feeding trial reported blood uptake that was significantly higher than a Bamboo-derived silicon supplement....
Published on Jun 7, 2018in Journal of Physical Chemistry A 2.64
Victor Volkov8
Estimated H-index: 8
(NTU: Nottingham Trent University),
David J. Belton14
Estimated H-index: 14
(NTU: Nottingham Trent University),
Carole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
Structural properties of bioinorganic composites are of current interest in the areas of drug delivery, bone repair, and biomimetics. In such composite systems, structural analysis is enhanced when we combine methods of spectroscopy and simulation. Depending on size and shape, structural discontinuities of inorganic matter may modulate the optical response of a bound molecule. Using density functional theory, we explore the effects of a local field next to the surface of a silica cluster on freq...
Published on Jun 1, 2018in Acta Biomaterialia 6.64
David J. Belton14
Estimated H-index: 14
(NTU: Nottingham Trent University),
Robyn Plowright3
Estimated H-index: 3
(NTU: Nottingham Trent University)
+ 1 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
Abstract The physical and mechanical properties of structural proteins such as silk fibroin can be modified by controlled conformational change, which is regularly monitored by Fourier transform infrared spectroscopy by peak fitting of the amide I band envelope. Although many variables affecting peak shape are well established, there is no fixed methodology to compare and follow secondary structural differences without significant operator input especially where low frequency spectral noise is a...
Published on Dec 1, 2017in Scientific Reports 4.01
Robyn Plowright3
Estimated H-index: 3
(NTU: Nottingham Trent University),
David J. Belton14
Estimated H-index: 14
(NTU: Nottingham Trent University)
+ 1 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
We present a non-destructive analytical calibration tool to allow quantitative assessment of individual calcium phosphates such as hydroxyapatite (HAP) from mixtures including brushite. Many experimental approaches are used to evaluate the mineralising capabilities of biomolecules including peptides. However, it is difficult to quantitatively compare the efficacy of peptides in the promotion of mineralisation when inseparable mixtures of different minerals are produced. To address this challenge...
Published on Feb 1, 2017in Acta Biomaterialia 6.64
Nina Dinjaski11
Estimated H-index: 11
(Tufts University),
Robyn Plowright3
Estimated H-index: 3
(NTU: Nottingham Trent University)
+ 3 AuthorsDavid L. Kaplan146
Estimated H-index: 146
(Tufts University)
Abstract Protein polymers provide a unique opportunity for tunable designs of material systems due to the genetic basis of sequence control. To address the challenge of biomineralization interfaces with protein based materials, we genetically engineered spider silks to design organic-inorganic hybrid systems. The spider silk inspired domain (SGRGGLGGQG AGAAAAAGGA GQGGYGGLGSQGT) 15 served as an organic scaffold to control material stability and to allow multiple modes of processing, whereas the h...
Published on Mar 1, 2016in Journal of Biological Inorganic Chemistry 3.63
Anna Sola-Rabada3
Estimated H-index: 3
(NTU: Nottingham Trent University),
Julia Rinck8
Estimated H-index: 8
(KIT: Karlsruhe Institute of Technology)
+ 2 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
Silica is the second most abundant biomineral being exceeded in nature only by biogenic CaCO3. Many land plants (such as rice, cereals, cucumber, etc.) deposit silica in significant amounts to reinforce their tissues and as a systematic response to pathogen attack. One of the most ancient species of living vascular plants, Equisetum arvense is also able to take up and accumulate silica in all parts of the plant. Numerous methods have been developed for elimination of the organic material and/or ...
Published on Jan 1, 2016in RSC Advances 3.05
Robyn Plowright3
Estimated H-index: 3
(NTU: Nottingham Trent University),
Nina Dinjaski11
Estimated H-index: 11
(Tufts University)
+ 3 AuthorsCarole C. Perry44
Estimated H-index: 44
(NTU: Nottingham Trent University)
Biomaterial design via genetic engineering can be utilized for the rational functionalization of proteins to promote biomaterial integration and tissue regeneration. Spider silk has been extensively studied for its biocompatibility, biodegradability and extraordinary material properties. As a protein-based biomaterial, recombinant DNA derived derivatives of spider silks have been modified with biomineralization domains which lead to silica deposition and potentially accelerated bone regeneration...
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