Gerald Nestadt
Johns Hopkins University School of Medicine
Publications 215
Published on Jan 1, 2019in Indian Journal of Psychiatry 1.06
Abhishek Purty , Gerald Nestadt65
Estimated H-index: 65
(Johns Hopkins University)
+ 1 AuthorsBiju Viswanath12
Estimated H-index: 12
Obsessive-compulsive disorder (OCD) has been seen to run in families and genetics help to understand its heritability. In this review, we summarize older studies which focused on establishing the familial nature of OCD, including its various dimensions of symptoms, and we focus on recent findings from studies using both the candidate gene approach and genome-wide association study (GWAS) approach. The family studies and twin studies establish the heritability of OCD. Candidate gene approaches ha...
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Published on Feb 1, 2019in Neuropsychology (journal) 2.70
Vidyulata Kamath8
Estimated H-index: 8
Jeffrey L. Crawford1
Estimated H-index: 1
+ 4 AuthorsDavid J. Schretlen42
Estimated H-index: 42
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Published on Mar 1, 2019in JAMA Psychiatry 16.64
Anna M. Wang1
Estimated H-index: 1
(Johns Hopkins University School of Medicine),
Subechhya Pradhan2
Estimated H-index: 2
(Johns Hopkins University School of Medicine)
+ 10 AuthorsLeslie G. Nucifora5
Estimated H-index: 5
(Johns Hopkins University School of Medicine)
Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain regions of a large population of human participants facilitates in vivo study of localized or diffusely altered brain metabolites in patients with first-episode psychosis (FEP) compared to healthy participants. Objective To compare metabolite levels in 5 brain regions between patients with FEP (evaluated within 2 years of onset) and healthy controls, and to explore possible associations between targeted meta...
2 Citations Source Cite
Published on Jan 1, 2019in European Neuropsychopharmacology 4.13
Matt Halvorsen4
Estimated H-index: 4
Jf. Samuels + 2 AuthorsDavid B. Goldstein89
Estimated H-index: 89
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Published on Jun 1, 2018in Cell 31.40
Douglas M. Ruderfer44
Estimated H-index: 44
(Icahn School of Medicine at Mount Sinai),
Stephan Ripke63
Estimated H-index: 63
(Vanderbilt University Medical Center)
+ 536 AuthorsLoes M. Olde Loohuis10
Estimated H-index: 10
Schizophrenia and bipolar disorder are two distinct diagnoses that share symptomology. Understanding the genetic factors contributing to the shared and disorder-specific symptoms will be crucial for improving diagnosis and treatment. In genetic data consisting of 53,555 cases (20,129 bipolar disorder [BD], 33,426 schizophrenia [SCZ]) and 54,065 controls, we identified 114 genome-wide significant loci implicating synaptic and neuronal pathways shared between disorders. Comparing SCZ to BD (23,585...
29 Citations Source Cite
Published on Jun 1, 2018in American Journal of Human Genetics 8.86
Guiyan Ni2
Estimated H-index: 2
(University of New England (Australia)),
Gerhard Moser1
Estimated H-index: 1
(University of New England (Australia))
+ 299 AuthorsMichael C. O’Donovan118
Estimated H-index: 118
Genetic correlation is a key population parameter that describes the shared genetic architecture of complex traits and diseases. It can be estimated by current state-of-art methods, i.e., linkage disequilibrium score regression (LDSC) and genomic restricted maximum likelihood (GREML). The massively reduced computing burden of LDSC compared to GREML makes it an attractive tool, although the accuracy (i.e., magnitude of standard errors) of LDSC estimates has not been thoroughly studied. In simulat...
9 Citations Source Cite
Published on Dec 1, 2018in Scientific Reports 4.12
Guiyan Ni2
Estimated H-index: 2
(University of South Australia),
Jacob Gratten22
Estimated H-index: 22
(University of Queensland)
+ 298 AuthorsPeter Holmans85
Estimated H-index: 85
(Cardiff University)
Previous studies have shown an increased risk for mental health problems in children born to both younger and older parents compared to children of average-aged parents. We previously used a novel design to reveal a latent mechanism of genetic association between schizophrenia and age at first birth in women (AFB). Here, we use independent data from the UK Biobank (N = 38,892) to replicate the finding of an association between predicted genetic risk of schizophrenia and AFB in women, and to esti...
3 Citations Source Cite
Caroline Yang (Johns Hopkins University), Gerald Nestadt65
Estimated H-index: 65
(Johns Hopkins University)
+ 1 AuthorsLeonard A. Doerfler18
Estimated H-index: 18
(Assumption College)
ABSTRACTThis study investigated cultural differences in beliefs about the etiology and management of OCD. Participants were 428 individuals from 13 countries in North America, Western Europe and South Asia who completed a questionnaire about a hypothetical individual who experienced OCD. Principal components analysis of the questionnaire items identified four factors; comparison of the four subscales revealed significant cross-cultural differences in how participants viewed the individual with O...
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Published on Jun 22, 2018in Science 41.06
Verneri Anttila27
Estimated H-index: 27
(Broad Institute),
Brendan Bulik-Sullivan19
Estimated H-index: 19
(Broad Institute)
+ 574 AuthorsBenjamin M. Neale75
Estimated H-index: 75
(Broad Institute)
Disorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common variant risk, whereas neurological disorders appear more distinct from one another and from ...
96 Citations Source Cite
Published on Feb 1, 2018in Comprehensive Psychiatry 2.13
Jack Samuels47
Estimated H-index: 47
(Johns Hopkins University School of Medicine),
O. Joseph Bienvenu40
Estimated H-index: 40
(Johns Hopkins University School of Medicine)
+ 19 AuthorsNicole McLaughlin11
Estimated H-index: 11
(Brown University)
Abstract Background Hoarding behavior may distinguish a clinically and possibly etiologically distinct subtype of obsessive-compulsive disorder (OCD). Little is known about the relationship between executive dysfunction and hoarding in individuals with OCD. Methods The study sample included 431 adults diagnosed with DSM-IV OCD. Participants were assessed by clinicians for Axis I disorders, personality disorders, indecision, and hoarding. Executive functioning domains were evaluated using a self-...
1 Citations Source Cite