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James K. Kirklin
University of Alabama at Birmingham
CardiologyIntensive care medicineHeart transplantationTransplantationMedicine
705Publications
68H-index
19.6kCitations
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#1Micah S. Brosbe (Johns Hopkins University)
#2Lydia K. Wright (Emory University)H-Index: 2
Last. James K. Kirklin (UAB: University of Alabama at Birmingham)H-Index: 68
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Educational development is an important component of quality of life for children with heart transplant. Aims include determining prevalence of and risk factors for modified education placement in a large representative sample of pediatric heart transplant recipients. Participants included 1495 patients (age 6-18 years) from the PHTS database. Data on education placement and clinical predictors were collected at listing and at 1 and 3 years post-transplant. At listing, 88% of patients were in ty...
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#1James K. Kirklin (UAB: University of Alabama at Birmingham)H-Index: 68
#2David C. Naftel (UAB: University of Alabama at Birmingham)H-Index: 61
Last. Paolo C. Colombo (NewYork–Presbyterian Hospital)H-Index: 35
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ABSTRACT Introduction Adverse events, and in particular strokes, during continuous flow durable left ventricular assist devices (LVAD) remain the major barrier to greater application among patients with ambulatory advanced heart failure. Methods Between June 2014 and June 2017, 9,489 patients in the STS INTERMACS database received 10,285 continuous flow left ventricular assist devices (CF LVAD), with follow-up through June 2018. Results During the follow-up period, 1515 (16%) patients suffered 1...
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Abstract Durable and temporary mechanical circulatory support (MCS) device support provides life-saving benefit for patients with advanced heart failure but is associated with major adverse events. The accurate categorization and documentation of adverse events associated with MCS device therapy has long been recognized as an essential requirement to adequately assess patient outcomes, inform patient decision making, provide critical feedback to advance patient management practices, and improve ...
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#1Anusha Jegatheeswaran (U of T: University of Toronto)H-Index: 10
#2Paul J. Devlin (U of T: University of Toronto)H-Index: 1
Last. Carlos M. Mery (University of Texas at Austin)H-Index: 12
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Structured abstract Objectives It remains unclear when sudden cardiac event risk outweighs surgical risk for anomalous aortic origin of a coronary artery (AAOCA) patients. The Congenital Heart Surgeons' Society sought to characterize the surgical risks by determining the techniques, complications, and outcomes of repair. Methods Between 01/2000-09/2018, 682 AAOCA patients age ≤30 years (y) were enrolled. Demographic, morphologic, operative, imaging, and ischemia-related data were analyzed. Resul...
2 CitationsSource
#1Jose B. Cruz Rodriguez (UAB: University of Alabama at Birmingham)
#2Garrick C. Stewart (Brigham and Women's Hospital)H-Index: 20
Last. Indika Mallawaarachchi (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 6
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BACKGROUND: Limited data exists regarding patients with continuous flow left ventricular assist device (LVAD) support who require long-term inotropes. Our primary objective was to evaluate the clinical characteristics and all-cause mortality of LVAD recipients with prolonged inotrope use (PIU). Secondary endpoints were to compare predictors of PIU, mortality, risk of late re-initiation of inotropes, time to gastrointestinal bleed (GIB), infection and arrhythmias. METHODS: Retrospective cohort st...
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#1Kathryn A. Stackhouse (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 4
#2Brian W. McCrindleH-Index: 88
Last. Gösta B. Pettersson (Cleveland Clinic)H-Index: 42
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Abstract Objectives To describe surgical pathway progression through adolescence of an inception cohort of neonates with aortic valve atresia managed initially with either surgical palliation or primary transplantation, comparing survival and self-reported health-related quality of life. Methods From 1994–2000, 565 neonates with aortic atresia were admitted to 26 Congenital Heart Surgeons’ Society hospitals and followed annually for vital status. Initial management included surgical palliation (...
1 CitationsSource
Purpose Our study aims to identify the utility of pre-implant MELD-XI score in identifying pediatric patients at higher risk for morbidity and mortality post-VAD implant. Methods We reviewed all patients listed in the PediMACS database from 9/19/12 to 3/31/19. Patients missing bilirubin or creatinine that precluded calculation of MELD-XI score (n=89) were excluded. Patients were divided into three cohorts based on MELD-XI score pre-implant - low (minimum score 9.4, 13.6, 75-100%-tile). Baseline ...
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#1Ike S. Okwuosa (NU: Northwestern University)H-Index: 4
#2Y. Xu (NU: Northwestern University)
Last. Duc Thinh Pham (NU: Northwestern University)H-Index: 16
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Purpose Heart transplantation (HT) and mechanical circulatory support (MCS) has improved heart failure (HF) patient (PT) outcomes; it has also led to increased caregiver (CG) responsibility pre and post-surgery. We assessed whether PT and CG factors were related to baseline CG perceived burden in 3 groups of CGs of HF PTs (60-80 years): (1) PT supported with MCS as a bridge to HT (HT BTT), (2) PT awaiting HT without MCS (HT non BTT), and (3) PT prior to MCS for destination therapy (DT MCS). Meth...
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