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Bianca Habermann
Aix-Marseille University
Molecular biologyGeneticsBioinformaticsBiologyCell biology
124Publications
49H-index
7,755Citations
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Publications 133
Newest
#1Marc Johnsen (University of Cologne)H-Index: 1
#1Marc JohnsenH-Index: 1
Last. Bianca HabermannH-Index: 49
view all 16 authors...
BACKGROUND: Although AKI lacks effective therapeutic approaches, preventive strategies using preconditioning protocols, including caloric restriction and hypoxic preconditioning, have been shown to prevent injury in animal models. A better understanding of the molecular mechanisms that underlie the enhanced resistance to AKI conferred by such approaches is needed to facilitate clinical use. We hypothesized that these preconditioning strategies use similar pathways to augment cellular stress resi...
1 CitationsSource
#1Friedhelm Pfeiffer (MPG: Max Planck Society)H-Index: 37
#2Gerald Losensky (Technische Universität Darmstadt)H-Index: 2
Last. Michael L. Dyall-Smith (MPG: Max Planck Society)H-Index: 38
view all 5 authors...
Halobacterium salinarum is an extremely halophilic archaeon that is widely distributed in hypersaline environments and was originally isolated as a spoilage organism of salted fish and hides. The type strain 91-R6 (DSM 3754(T) ) has seldom been studied and its genome sequence has only recently been determined by our group. The exact relationship between the type strain and two widely used model strains, NRC-1 and R1, has not been described before. The genome of Hbt. salinarum strain 91-R6 consis...
2 CitationsSource
#1Annie Yim (MPG: Max Planck Society)H-Index: 2
#2Prasanna Koti (MPG: Max Planck Society)H-Index: 2
Last. Bianca Habermann (AMU: Aix-Marseille University)H-Index: 49
view all 12 authors...
Mitochondria participate in metabolism and signaling. They adapt to the requirements of various cell types. Publicly available expression data permit to study expression dynamics of genes with mitochondrial function (mito-genes) in various cell types, conditions and organisms. Yet, we lack an easy way of extracting these data for mito-genes. Here, we introduce the visual data mining platform mitoXplorer, which integrates expression and mutation data of mito-genes with a manually curated mitochon...
1 CitationsSource
#1Jin-Ho Yun (KAIST)H-Index: 3
#2Michaël Pierrelée (AMU: Aix-Marseille University)
Last. Hee-Sik KimH-Index: 28
view all 12 authors...
Previously, we isolated Chlorella sp. HS2 (referred hereupon HS2) from a local tidal rock pool and demonstrated its halotolerance and relatively high biomass productivity under different salinity conditions. To further understand acclimation responses of this alga against high salinity stress, we performed transcriptome analysis of triplicated culture samples grown in freshwater and marine conditions at both exponential and stationary growth phases. De novo assembly followed by differential expr...
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#1Dorian Chabbert (AMU: Aix-Marseille University)H-Index: 1
#2Xavier Caubit (AMU: Aix-Marseille University)H-Index: 16
Last. Paolo Gubellini (AMU: Aix-Marseille University)H-Index: 41
view all 16 authors...
Abstract Background Heterozygous deletion of the TSHZ3 gene, encoding for the teashirt zinc-finger homeobox family member 3 (TSHZ3) transcription factor that is highly expressed in cortical projection neurons (CPNs), has been linked to an autism spectrum disorder (ASD) syndrome. Similarly, mice with Tshz3 haploinsufficiency show ASD-like behavior, paralleled by molecular changes in CPNs and corticostriatal synaptic dysfunctions. Here, we aimed at gaining more insight into “when” and “where” TSHZ...
1 CitationsSource
#1Stéphane G. Rolland (LMU: Ludwig Maximilian University of Munich)H-Index: 2
#2Sandra Schneid (LMU: Ludwig Maximilian University of Munich)
Last. Barbara Conradt (LMU: Ludwig Maximilian University of Munich)H-Index: 15
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Summary The induction of the mitochondrial unfolded protein response (UPRmt) results in increased transcription of the gene encoding the mitochondrial chaperone HSP70. We systematically screened the C. elegans genome and identified 171 genes that, when knocked down, induce the expression of an hsp-6 HSP70 reporter and encode mitochondrial proteins. These genes represent many, but not all, mitochondrial processes (e.g., mitochondrial calcium homeostasis and mitophagy are not represented). Knockdo...
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#1Friedhelm Pfeiffer (MPG: Max Planck Society)H-Index: 37
#2Anita Marchfelder (University of Ulm)H-Index: 30
Last. Michael L. Dyall-Smith (MPG: Max Planck Society)H-Index: 38
view all 4 authors...
ABSTRACT High-coverage long-read sequencing of the Halobacterium salinarum type strain (91-R6) revealed a 2.17-Mb chromosome and two large plasmids (148 and 102 kb). Population heterogeneity and long repeats were observed. Strain 91-R6 and laboratory strain R1 showed 99.63% sequence identity in common chromosomal regions and only 38 strain-specific segments. This information resolves the previously uncertain relationship between type and laboratory strains.
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#1Eduardo Silva Ramos (MPG: Max Planck Society)H-Index: 3
#2Elisa Motori (MPG: Max Planck Society)H-Index: 17
Last. Arnaud Mourier (University of Bordeaux)H-Index: 6
view all 13 authors...
Mitochondrial dynamics is an essential physiological process controlling mitochondrial content mixing and mobility to ensure proper function and localization of mitochondria at intracellular sites of high-energy demand. Intriguingly, for yet unknown reasons, severe impairment of mitochondrial fusion drastically affects mtDNA copy number. To decipher the link between mitochondrial dynamics and mtDNA maintenance, we studied mouse embryonic fibroblasts (MEFs) and mouse cardiomyocytes with disruptio...
4 CitationsSource
#1Markus Höpfler (MPG: Max Planck Society)
#2Maximilian Kern (MPG: Max Planck Society)H-Index: 2
Last. Stefan Jentsch (MPG: Max Planck Society)H-Index: 61
view all 7 authors...
Abstract Chromatin is a highly regulated environment, and protein association with chromatin is often controlled by post‐translational modifications and the corresponding enzymatic machinery. Specifically, SUMO‐targeted ubiquitin ligases (STUbLs) have emerged as key players in nuclear quality control, genome maintenance, and transcription. However, how STUbLs select specific substrates among myriads of SUMOylated proteins on chromatin remains unclear. Here, we reveal a remarkable co‐localization...
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#1Annie Yim (MPG: Max Planck Society)H-Index: 2
#2Prasanna Koti (MPG: Max Planck Society)H-Index: 2
Last. Bianca Habermann (AMU: Aix-Marseille University)H-Index: 49
view all 11 authors...
Abstract Background Mitochondria produce cellular energy in the form of ATP and are involved in various metabolic and signaling processes. However, the cellular requirements for mitochondria are different depending on cell type, cell state or organism. Information on the expression dynamics of genes with mitochondrial functions (mito-genes) is embedded in publicly available transcriptomic or proteomic studies and the variety of available datasets enables us to study the expression dynamics of mi...
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