Anders Hamsten
Karolinska Institutet
Publications 762
#1Lars Lind (Uppsala University)H-Index: 98
#2Bruna Gigante (KI: Karolinska Institutet)H-Index: 41
Last.Gunnar Engström (Lund University)H-Index: 58
view all 15 authors...
Abstract Background and aims Genetic loci associated with CHD show different relationships with the intima-media thickness in the common carotid artery (IMT-CCA) and in the bulb (IMT-bulb). We evaluated if IMT-CCA and IMT-bulb differ also with respect to circulating protein profiles and risk of incident atherosclerotic disease. Methods In three Swedish cohorts (MDC, IMPROVE, PIVUS, total n > 7,000), IMT-CCA and IMT-bulb were assessed by ultrasound at baseline and 86 cardiovascular-related protei...
#1Alice BonomiH-Index: 9
#2Fabrizio VegliaH-Index: 57
Last.Bruna Gigante (KI: Karolinska Institutet)H-Index: 41
view all 14 authors...
The genes regulating circulating levels of soluble gp130 (sgp130), the antagonist of the inflammatory response in atherosclerosis driven by interleukin 6, are largely unknown. Aims of the present study were to identify genetic loci associated with circulating sgp130 and to explore the potential association between variants associated with sgp130 and markers of subclinical atherosclerosis. The study is based on IMPROVE (n = 3703), a cardiovascular multicentre study designed to investigate the det...
#1U. Rykaczewska (KI: Karolinska Institutet)
#2Bianca E Suur (KI: Karolinska Institutet)H-Index: 1
Last.Ljubica Perisic Matic (KI: Karolinska Institutet)H-Index: 10
view all 29 authors...
Rationale: Proprotein convertase subtilisins/kexins (PCSKs) are a protease family with unknown functions in vasculature. Previously, we demonstrated PCSK6 upregulation in human atherosclerotic plaq...
#1Robin G Walters (University of Oxford)H-Index: 3
#2David W. Clark (Edin.: University of Edinburgh)H-Index: 6
Last.James F. Wilson (Edin.: University of Edinburgh)H-Index: 107
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In many species, the offspring of related parents suffer reduced reproductive success, a phenomenon known as inbreeding depression. In humans, the importance of this effect has remained unclear, partly because reproduction between close relatives is both rare and frequently associated with confounding social factors. Here, using genomic inbreeding coefficients (FROH) for >1.4 million individuals, we show that FROH is significantly associated (p < 0.0005) with apparently deleterious changes in 32...
1 CitationsSource
#1Julia Morris (Glas.: University of Glasgow)
#2Mark E.S. Bailey (Glas.: University of Glasgow)H-Index: 29
Last.Rona J. Strawbridge (Glas.: University of Glasgow)H-Index: 36
view all 24 authors...
CADM2 has been associated with a range of behavioural and metabolic traits, including physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity. Here, we set out to determine whether CADM2 contributes to mechanisms shared between mental and physical health disorders. We assessed genetic variants in the CADM2 locus for association with phenotypes in the UK Biobank, IMPROVE, PROCARDIS and SCARFSHEEP studies, before performing meta-analyses. A wide range of metabo...
#1P. Saliba-gustafsson (Stanford University)
#2M. Pedrelli (KI: Karolinska Institutet)H-Index: 8
Last.Ewa Ehrenborg (KI: Karolinska Institutet)H-Index: 32
view all 25 authors...
Background Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective We sought to delineate putative beneficial effects of the Pro251 variant of perlipin-2 on subclinical atherosclerosis and the mechanism by which it acts. Methods ...
(1) Background: In a previous study, we found that two phenotypes related to platelet reactivity, measured with the PFA-100 system, were highly heritable. The aim of the present study was to identify genetic determinants that influence the variability of these phenotypes: closure time of collagen-ADP (Col-ADP) and of collagen-epinephrine (Col-Epi). (2) Methods: As part of the GAIT-2 (Genetic Analysis of Idiopathic Thrombophilia (2) Project, 935 individuals from 35 large Spanish families were stu...
#1Fabrizio VegliaH-Index: 57
#2Damiano Baldassarre (University of Milan)H-Index: 35
Last.Elena Tremoli (University of Milan)H-Index: 2
view all 20 authors...
Abstract Background The Mediterranean Diet (MD) is a model of healthy eating contributing to a favorable health status, but its clinical usefulness is still debated. The aim of this study was to relate the adherence to MD with the incidence of cardio/cerebro-vascular events (VEs) in north and south European participants of the IMPROVE study. Methods IMPROVE is an observational, longitudinal, prospective cohort study involving 3703 individuals from five European countries (Finland, Sweden, Nether...
2 CitationsSource
#1Fabrizio VegliaH-Index: 57
#2Damiano Baldassarre (University of Milan)H-Index: 35
Last.Elena Tremoli (University of Milan)H-Index: 63
view all 20 authors...
Abstract Data presented in this article are related to the research article entitled “A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries” [Veglia et al., 2018]. Data contain information about the incidence of cardiovascular events in a high-risk European population (IMPROVE study) [Baldassarre et al., 2010, 2012, 2013]. Combined vascular events, as well as cardio- and cerebro-vascular events were stratified ac...