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Abid H. Banday
University of Arizona
9Publications
5H-index
95Citations
Publications 9
Newest
#1Yang ZhouH-Index: 2
#2Abid H. BandayH-Index: 5
Last.Minying CaiH-Index: 20
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Cancer vaccine is a promising immunotherapeutic approach to train the immune system with vaccines to recognize and eliminate tumors. Adjuvants are compounds that are necessary in cancer vaccines to mimic an infection process and amplify immune responses. The Toll-like receptor 2 and 6 (TLR2/TLR6) agonist dipalmitoyl-S-glyceryl cysteine (Pam2Cys) was demonstrated as an ideal candidate for synthetic vaccine adjuvants. However, the synthesis of Pam2Cys requires expensive N-protected cysteine as a k...
#1Abid H. Banday (UA: University of Arizona)H-Index: 5
#2Salika Jeelani (University of Kashmir)H-Index: 3
Last.Victor J. Hruby (UA: University of Arizona)H-Index: 78
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AbstractDespite recent breakthroughs in the prognosis, prevention and treatment, cancer still remains the leading cause of death and affects millions of people worldwide. With the US FDA approval of various preventive cancer vaccines such as Gardasil (Merck), Cervarix (Glaxosmithkline) and the therapeutic vaccine Sipulencel-T (Provenge), cancer vaccine development is gaining huge ground. Approval of these vaccines has encouraged the concept of cancer treatment through cellular immunotherapy. The...
#1Yang ZhouH-Index: 2
#2Abid H. BandayH-Index: 5
Last.Victor J. HrubyH-Index: 78
view all 4 authors...
Synthetic vaccines use synthetic molecules as antigens for vaccination. Since real pathogens are no longer needed in synthetic vaccines, they are considered safer than the traditional inactivated or attenuated vaccines. The development of synthetic vaccines can be achieved on the genome sequence of the pathogen, which is much more efficient than the traditional way of sampling pathogens from the outbreak and grow cultures. Despite these advantages, the development of synthetic vaccines is hinder...
#1Abid H. Banday (Islamia College)H-Index: 5
#2Vinod Kulkarni (UA: University of Arizona)H-Index: 6
Last.Victor J. Hruby (UA: University of Arizona)H-Index: 78
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A series of new compounds consisting of epipodophyllotoxin–chalcone hybrids was synthesized towards the development of better anticancer lead molecules. These hybrids consist of structurally different but functionally similar topoisomerase-II inhibitors which were conjugated together through click-chemistry. Their design is aimed at the synthesis of novel chemotherapeutics with a better target-protein interaction and higher bioavailability. Evaluation of the anticancer activity of these designed...
#1Abid H. Banday (Islamia College)H-Index: 5
#2Shameem A. Shameem (Islamia College)H-Index: 4
Last.Salika Jeelani (University of Kashmir)H-Index: 3
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Taking pregnenolone as the starting material, two series of pyrazolinyl and pyrazolyl pregnenolones were synthesized through different routes. The synthesis of the analogs of both series is multistep and proceeds in good overall yields. While the key step in the synthesis of pyrazolinyl pregnenolones is the heterocyclization of benzylidine derivatives (3) in presence of hydrazine hydrate, it is the condensation of 3β-hydroxy-21-hydroxymethylidenepregn-5-en-3β-ol-20-one (5) with phenylhydrazine i...
#1Abid H. Banday (Islamia College)H-Index: 5
#2Aswini Kumar Giri (UA: University of Arizona)H-Index: 4
Last.Nusrat Bashir (Islamia College)H-Index: 1
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Abstract Two series of novel steroidal isoxazolines and oxazolines were synthesized through different routes from dehydroepiandrosterone acetate and pregnenolone acetate, respectively. The synthesis of the analogs of both series is multistep and proceeds in good overall yields. While the key step in the synthesis of former is the cycloaddition of aromatic nitrile oxides across α,β-unsaturated olefins, it is the condensation of α,β-azidoalcohols with aromatic aldehydes in the later. Compounds of ...
#1Abid H. Banday (Islamia College)H-Index: 5
#2Victor J. Hruby (UA: University of Arizona)H-Index: 78
An unprecedented, one-pot regioselective synthesis of 1,2,3-triazole-fused heterocycles through Cu(I)–Pd(II) cycloaddition–fusion of 1-iodoalkynes and organic azides is described. The method presents a convenient heteroannulation approach towards the synthesis of polycyclic frameworks from easily accessible substrates.
#1Abid H. Banday (UA: University of Arizona)H-Index: 5
#2Victor J. Hruby (UA: University of Arizona)H-Index: 78
An unprecedented, one-pot regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles through N/C-heterocyclization of allenylindium bromide across aryl azides is described. The synthesis is carried out under mild conditions in aqueous medium and proceeds regioselectively in moderate to good yields.
#1Abid H. Banday (Islamia College)H-Index: 5
#2S.M.M. Akram (Islamia College)H-Index: 1
Last.Shameem A. Shameem (Islamia College)H-Index: 4
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Abstract The present study reveals the anticancer activity of benzylidine pregnenolones and their oxime derivatives. The synthesis of the analogs of both series is very simple and involves aldol condensation in the first step followed by nucleophillic addition of hydroxylamine across carbonyl in the second step. Quantitative yields of more than 80% are obtained in both the steps. All the compounds were tested for their cytotoxic activities against a panel of six human cancer cell lines. Amongst ...
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