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Timo A. Lakka
University of Eastern Finland
Publications 334
Published on Jan 22, 2019in Nature Communications 12.35
Tuomas O. Kilpelaeinen31
Estimated H-index: 31
(Icahn School of Medicine at Mount Sinai),
Amy R. Bentley15
Estimated H-index: 15
(National Institutes of Health)
+ 234 AuthorsIoanna Ntalla27
Estimated H-index: 27
(Queen Mary University of London)
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
4 Citations Source Cite
Published on Mar 1, 2019in BMC Public Health 2.42
Jussi Pihlajamäki43
Estimated H-index: 43
(University of Eastern Finland),
Reija Männikkö4
Estimated H-index: 4
(University of Eastern Finland)
+ 14 AuthorsMarja Harjumaa8
Estimated H-index: 8
(VTT Technical Research Centre of Finland)
Background The StopDia study is based on the convincing scientific evidence that type 2 diabetes (T2D) and its comorbidities can be prevented by a healthy lifestyle. The need for additional research is based on the fact that the attempts to translate scientific evidence into actions in the real-world health care have not led to permanent and cost-effective models to prevent T2D. The specific aims of the StopDia study following the Reach, Effectiveness, Adoption, Implementation, and Maintenance (...
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Published on Jan 29, 2019in American Journal of Epidemiology 4.32
P S de Vries2
Estimated H-index: 2
(University of Texas Health Science Center at Houston),
M Brown7
Estimated H-index: 7
(University of Texas Health Science Center at Houston)
+ 261 AuthorsNora Franceschini50
Estimated H-index: 50
(University of North Carolina at Chapel Hill)
3 Citations Source Cite
Published on Jun 1, 2019in Human Brain Mapping 4.93
Sara Määttä20
Estimated H-index: 20
Laura Säisänen16
Estimated H-index: 16
+ 7 AuthorsMervi Könönen34
Estimated H-index: 34
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D. Leland Taylor4
Estimated H-index: 4
(National Institutes of Health),
Anne U. Jackson71
Estimated H-index: 71
(University of Michigan)
+ 19 AuthorsRyan P. Welch17
Estimated H-index: 17
(University of Michigan)
We integrate comeasured gene expression and DNA methylation (DNAme) in 265 human skeletal muscle biopsies from the FUSION study with >7 million genetic variants and eight physiological traits: height, waist, weight, waist–hip ratio, body mass index, fasting serum insulin, fasting plasma glucose, and type 2 diabetes. We find hundreds of genes and DNAme sites associated with fasting insulin, waist, and body mass index, as well as thousands of DNAme sites associated with gene expression (eQTM). We ...
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Published on May 1, 2019in Pediatric Exercise Science 1.35
Andrew O. Agbaje1
Estimated H-index: 1
(University of Eastern Finland),
Eero A. Haapala9
Estimated H-index: 9
(University of Jyväskylä)
+ 7 AuthorsTimo A. Lakka78
Estimated H-index: 78
(University of Eastern Finland)
Purpose: To investigate the associations of directly measured peak oxygen uptake (V˙O2peak) and body fat percentage (BF%) with arterial stiffness and arterial dilatation capacity in children. Metho...
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Published on May 1, 2019in Nature Genetics 27.13
Nicole M. Warrington31
Estimated H-index: 31
(Translational Research Institute),
Robin N. Beaumont12
Estimated H-index: 12
(Royal Devon and Exeter Hospital)
+ 205 AuthorsBjarke Feenstra32
Estimated H-index: 32
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors, and has been reproducibly associated with future cardio-metabolic health outcomes. In expanded genome-wide association analyses of own birth weight (n = 321,223) and offspring birth weight (n = 230,069 mothers), we identified 190 independent association signals (129 of which are novel). We used structural equation modeling to decompose the contributions of direct fetal and indirect maternal genetic effect...
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Published on May 1, 2019in Brain Topography 2.70
Laura Säisänen16
Estimated H-index: 16
(University of Eastern Finland),
Sara Määttä20
Estimated H-index: 20
(University of Eastern Finland)
+ 10 AuthorsAino-Maija Eloranta9
Estimated H-index: 9
(University of Eastern Finland)
Motor functions are frequently impaired in Asperger syndrome (AS). In this study, we examined the motor cortex structure and function using navigated transcranial magnetic stimulation (nTMS) and voxel-based morphometry (VBM) and correlated the results with the box and block test (BBT) of manual dexterity and physical activity in eight boys with AS, aged 8–11 years, and their matched controls. With nTMS, we found less focused cortical representation areas of distinct hand muscles in AS. There was...
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