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Timo A. Lakka
University of Eastern Finland
353Publications
80H-index
26.9kCitations
Publications 353
Newest
#1Tuomas O. Kilpelaeinen (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 33
#2Amy R. Bentley (NIH: National Institutes of Health)H-Index: 16
Last.Ruth Loos (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 111
view all 237 authors...
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We f...
6 CitationsSource
#1Jussi Pihlajamäki (University of Eastern Finland)H-Index: 48
#2Reija Männikkö (University of Eastern Finland)H-Index: 4
Last.Timo A. Lakka (University of Eastern Finland)H-Index: 80
view all 17 authors...
The StopDia study is based on the convincing scientific evidence that type 2 diabetes (T2D) and its comorbidities can be prevented by a healthy lifestyle. The need for additional research is based on the fact that the attempts to translate scientific evidence into actions in the real-world health care have not led to permanent and cost-effective models to prevent T2D. The specific aims of the StopDia study following the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) fra...
1 CitationsSource
#1Anna Viitasalo (UCPH: University of Copenhagen)H-Index: 11
#2Theresia M. Schnurr (UCPH: University of Copenhagen)H-Index: 5
Last.Tuomas O. Kilpelaeinen (UCPH: University of Copenhagen)H-Index: 33
view all 22 authors...
Most obese children show cardiometabolic impairments, such as insulin resistance, dyslipidemia, and hypertension. Yet some obese children retain a normal cardiometabolic profile. The mechanisms underlying this variability remain largely unknown. We examined whether genetic loci associated with increased insulin sensitivity and relatively higher fat storage on the hip than on the waist in adults are associated with a normal cardiometabolic profile despite higher adiposity in children. We construc...
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#1Aapo Veijalainen (University of Eastern Finland)H-Index: 5
#2Eero A. Haapala (University of Eastern Finland)H-Index: 10
Last.Timo A. Lakka (University of Eastern Finland)H-Index: 80
view all 12 authors...
Purpose To study the associations of physical activity (PA), sedentary time (ST), and cardiorespiratory fitness (CRF) with heart rate variability (HRV) in children.
Source
#1Alexessander Couto Alves (University of Surrey)H-Index: 23
#2N. Maneka G. De Silva (Imperial College London)H-Index: 3
Last.Marjo-Ritta JarvelinH-Index: 120
view all 91 authors...
Early childhood growth patterns are associated with adult health, yet the genetic factors and the developmental stages involved are not fully understood. Here, we combine genome-wide association studies with modeling of longitudinal growth traits to study the genetics of infant and child growth, followed by functional, pathway, genetic correlation, risk score, and colocalization analyses to determine how developmental timings, molecular pathways, and genetic determinants of these traits overlap ...
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#1Anna Viitasalo (UCPH: University of Copenhagen)H-Index: 11
#2Theresia M. Schnurr (UCPH: University of Copenhagen)H-Index: 5
Last.Tuomas O. Kilpelaeinen (UCPH: University of Copenhagen)H-Index: 33
view all 23 authors...
Source
#1Jari A. Laukkanen (University of Jyväskylä)H-Index: 36
#2Timo A. Lakka (University of Eastern Finland)H-Index: 80
Last.Setor K. Kunutsor (UoB: University of Bristol)H-Index: 27
view all 5 authors...
1 CitationsSource
#1Yun J. Sung (WashU: Washington University in St. Louis)H-Index: 7
#2L de Las Fuentes (WashU: Washington University in St. Louis)H-Index: 2
Last.Alanna C. Morrison (University of Texas Health Science Center at Houston)H-Index: 44
view all 279 authors...
U.S. National Heart, Lung, and Blood Institute (NHLBI) (K25HL121091 to Y.J.S.); National Institutes of Health (R01HL118305).
Source
#1Laura SäisänenH-Index: 16
#2Niina Lintu (University of Eastern Finland)H-Index: 11
Last.Sara MäättäH-Index: 20
view all 5 authors...
Background The interhemispheric difference in cortical excitability and its relationship to motor functions is unclear. Aim We examined the relationship between handedness, left and right motor cortex excitability and fine and gross motor functions in adolescence. Methods 28 healthy adolescents (age 16–19 years, 19 girls) were studied. Handedness was determined by the Waterloo Handedness Questionnaire. Motor threshold (MT) of the abductor pollicis brevis was measured on both hemispheres using bi...
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#1Laura SäisänenH-Index: 16
#2Eero A. Haapala (University of Jyväskylä)H-Index: 10
Last.Sara MäättäH-Index: 20
view all 5 authors...
Background Sex is known to influence brain development. However, sex differences in cortical excitability and their relationship to motor functions is unclear. Aim We examined the sex related differences in the degree of handedness, left and right motor cortex excitability and manual dexterity. Methods 28 healthy adolescents (age 16–19 years,19 girls) were studied. The degree of right-handedness was determined by the Waterloo Handedness Questionnaire. Motor threshold (MT) of the abductor pollici...
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