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Peter K. Joshi
University of Edinburgh
118Publications
21H-index
2,036Citations
Publications 118
Newest
#1Gail Davies (Edin.: University of Edinburgh)H-Index: 46
#2Max LamH-Index: 11
Last.Ian J. Deary (Edin.: University of Edinburgh)H-Index: 121
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Christina M. Lill, who contributed to analysis of data, was inadvertently omitted from the author list in the originally published version of this article. This has now been corrected in both the PDF and HTML versions of the article.
#1Peter Lenart (Masaryk University)H-Index: 3
#2Daniela Kuruczová (Masaryk University)H-Index: 1
Last.Julie Bienertova-Vasku (Masaryk University)H-Index: 15
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Women on average live longer than men, which seems to suggest that women also age slower than men. However, the potential difference in the pace of aging between the sexes is a relatively controversial topic, and both positions, i.e. “men age faster” and “men and women age at the same pace”, have found some support. We therefore employ parametric models previously established in model organisms as well as two nonparametric approaches to compare the pace of aging between the sexes using freely av...
#1Xue Li (Edin.: University of Edinburgh)H-Index: 5
#2Xiangrui Meng (Edin.: University of Edinburgh)H-Index: 4
Last.Evropi Theodoratou (Edin.: University of Edinburgh)H-Index: 40
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Background The role of urate in cardiovascular diseases (CVDs) has been extensively investigated in observational studies; however, the extent of any causal effect remains unclear, making it difficult to evaluate its clinical relevance. Methods and findings A phenome-wide association study (PheWAS) together with a Bayesian analysis of tree-structured phenotypic model (TreeWAS) was performed to examine disease outcomes related to genetically determined serum urate levels in 339,256 unrelated Whit...
#1Abirami Veluchamy (Dund.: University of Dundee)H-Index: 5
#2Lucia Ballerini (Dund.: University of Dundee)H-Index: 19
Last.Alex S. F. Doney (Dund.: University of Dundee)H-Index: 53
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Objective: The retina may provide readily accessible imaging biomarkers of global cardiovascular health. Increasing evidence suggests variation in retinal vascular traits is highly heritable. This ...
#1Katherine A. Kentistou (Edin.: University of Edinburgh)H-Index: 2
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Obesity has now reached pandemic levels, with a quarter of the world’s population being overweight or obese and thus at a greater risk of developing type 2 diabetes (T2D) and cardiovascular disease (CVD) [ 1 ]. Largescale biobanks, combined with genome-wide discovery efforts, have identified thousands of loci associated with obesity traits including body composition, fat distribution and their causal relationships with disease risk. These findings have begun to shed light on some of the biologic...
#1Adrienne Tin (Johns Hopkins University)H-Index: 19
#2Jonathan Marten (Medical Research Council)H-Index: 18
Last.Anna Köttgen (Johns Hopkins University)H-Index: 49
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Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for p...
Britain and Ireland are known to show population genetic structure; however, large swathes of Scotland, in particular, have yet to be described. Delineating the structure and ancestry of these populations will allow variant discovery efforts to focus efficiently on areas not represented in existing cohorts. Thus, we assembled genotype data for 2,554 individuals from across the entire archipelago with geographically restricted ancestry, and performed population structure analyses and comparisons ...
#1Xiangrui Meng (Edin.: University of Edinburgh)H-Index: 4
#2Xue Li (Edin.: University of Edinburgh)H-Index: 5
Last.Evropi Theodoratou (Edin.: University of Edinburgh)H-Index: 40
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#1Evangelos Evangelou (Imperial College London)H-Index: 44
#2He Gao (Imperial College London)H-Index: 15
Last.Perry M. ElliottH-Index: 143
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Excessive alcohol consumption is one of the main causes of death and disability worldwide. Alcohol consumption is a heritable complex trait. Here we conducted a meta-analysis of genome-wide association studies of alcohol consumption (g d−1) from the UK Biobank, the Alcohol Genome-Wide Consortium and the Cohorts for Heart and Aging Research in Genomic Epidemiology Plus consortia, collecting data from 480,842 people of European descent to decipher the genetic architecture of alcohol intake. We ide...
#1Paul R. H. J. Timmers (Edin.: University of Edinburgh)H-Index: 4
Last.Peter K. Joshi (Edin.: University of Edinburgh)H-Index: 21
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Objectives: To identify the causes and future trends underpinning improvements in life expectancy in Scotland and quantify the relative contributions of disease incidence and survival. Design: Population-based study. Setting: Linked secondary care and mortality records across Scotland. Participants: 1,967,130 individuals born between 1905 and 1965, and resident in Scotland throughout 2001-2016. Main outcome measures: Hospital admission rates and survival in the five years following admission for...
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