Stephen M. Lawrie
University of Edinburgh
PsychiatryPsychologyPsychosisClinical psychologySchizophrenia
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Publications 513
#1Audrey Millar (Edin.: University of Edinburgh)
#2Liesbeth Tip (Edin.: University of Edinburgh)H-Index: 1
Last. Matthias Schwannauer (Edin.: University of Edinburgh)H-Index: 17
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BACKGROUND Patients within psychiatric rehabilitation services have multiple, complex and enduring difficulties, and are frequently described as 'treatment resistant'. This group have diagnoses of major mental health conditions, most commonly schizophrenia, often alongside a history of complex trauma, co-morbid alcohol/ substance misuse, and cognitive impairment. There is no known effective medical treatment other than Clozapine in this patient group, however, there is preliminary evidence that ...
#1Aleks Stolicyn (Royal Edinburgh Hospital)
#2Mathew A. Harris (Royal Edinburgh Hospital)
Last. Stephen M. Lawrie (Royal Edinburgh Hospital)H-Index: 79
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Major depressive disorder (MDD) has been the subject of many neuroimaging case-control classification studies. Although some studies report accuracies ≥80%, most have investigated relatively small samples of clinically-ascertained, currently symptomatic cases, and did not attempt replication in larger samples. We here first aimed to replicate previously reported classification accuracies in a small, well-phenotyped community-based group of current MDD cases with clinical interview-based diagnose...
#1Samuel Rupprechter (Edin.: University of Edinburgh)H-Index: 2
#2Liana Romaniuk (Edin.: University of Edinburgh)H-Index: 18
Last. Mathew A. Harris (Edin.: University of Edinburgh)H-Index: 2
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Major depressive disorder is a leading cause of disability and significant mortality, yet mechanistic understanding remains limited. Over the past decade evidence has accumulated from case-control studies that depressive illness is associated with blunted reward activation in the basal ganglia and other regions such as the medial prefrontal cortex. However it is unclear whether this finding can be replicated in a large number of subjects. The functional anatomy of the medial prefrontal cortex an...
#1Anushka Pathak (Edin.: University of Edinburgh)
#2Elizabeth Lim (Edin.: University of Edinburgh)
Last. Stephen M. Lawrie (Edin.: University of Edinburgh)H-Index: 79
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BACKGROUND It is well-established that media influences public perceptions, and that media coverage of psychiatry is negative compared to the rest of medicine. No studies that we know of, have compared media reporting on antidepressants and talking therapies as treatments for depression. We hypothesised that coverage of antidepressants would be more negative than that of psychotherapies in both headlines and articles. METHODS We identified online articles in The Sun, Daily Mirror, Daily Mail, Da...
#1Ahmad Abu-Akel (UNIL: University of Lausanne)H-Index: 17
#2Ruth C. M. PhilipH-Index: 6
Last. Andrew C. Stanfield (Edin.: University of Edinburgh)H-Index: 23
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#1Kate Haining (Glas.: University of Glasgow)H-Index: 1
#2Gina Brunner (Glas.: University of Glasgow)
Last. Peter J. Uhlhaas (Glas.: University of Glasgow)H-Index: 41
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#1Katie Richards ('KCL': King's College London)H-Index: 1
#2Povilas Karvelis (Edin.: University of Edinburgh)H-Index: 3
Last. Peggy Seriès (Edin.: University of Edinburgh)H-Index: 20
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Deficits in statistical learning and predictive processing could in principle explain inattention and distractibility in attention deficit hyperactivity disorder (ADHD). To test this, we evaluated whether adults diagnosed with ADHD (n = 17) differed from controls (n = 30) in implicitly learning and using low-level perceptual priors to guide sensory processing. We used a visual statistical learning task in which participants had to estimate the direction of coherently moving dots. Unbeknown to th...
#1Emily R. Cox (Royal Edinburgh Hospital)
#2Katie F. M. Marwick (Royal Edinburgh Hospital)H-Index: 7
Last. Stephen M. Lawrie (Royal Edinburgh Hospital)H-Index: 79
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: Increasing evidence suggests that circulating factors and immune dysfunction may contribute to the pathogenesis of schizophrenia. In particular, proinflammatory cytokines, complement and autoantibodies against CNS epitopes have recently been associated with psychosis. Related concepts in previous decades led to several clinical trials of dialysis and plasmapheresis as treatments for schizophrenia. These trials may have relevance for the current understanding of schizophrenia. We aimed to ident...
#1Mark Corcoran (National University of Ireland, Galway)H-Index: 1
#2Emma L. Hawkins (Edin.: University of Edinburgh)H-Index: 4
Last. Maria R. Dauvermann (University of Cambridge)H-Index: 1
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OBJECTIVE: Occurrences of early-life stress (ELS) are associated with the severity of psychotic symptoms and working memory (WM) deficits in patients with psychosis (PSY). This study investigated potential mediation roles of WM behavioral performance and glutamate concentrations in prefrontal brain regions on the association between ELS and psychotic symptom severity in PSY. METHOD: Forty-seven patients with PSY (established schizophrenia, n = 30; bipolar disorder, n = 17) completed measures of ...
1 CitationsSource
#1Andrew McKechanie (Edin.: University of Edinburgh)H-Index: 10
#2Stephen M. Lawrie (Edin.: University of Edinburgh)H-Index: 79
Last. Andrew C. Stanfield (Edin.: University of Edinburgh)H-Index: 23
view all 3 authors...