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James A. King
National Health Service
72Publications
16H-index
1,184Citations
Publications 77
Newest
#1Joseph Henson (University of Leicester)H-Index: 11
#2Charlotte L. Edwardson (University of Leicester)H-Index: 25
Last.Thomas Yates (University of Leicester)H-Index: 32
view all 16 authors...
PurposeTo identify predictors of favourable changes to postprandial insulin and glucose levels in response to interrupting prolonged sitting time with standing or light intensity physical activity.MethodsData were combined from four similarly designed randomised acute cross-over trials (n=129; BMI range 19.6 to 44.6kg/m2; South Asian=31.0%; dysglycaemia=27.1%). Treatments included: prolonged sitting (6.5hours) or prolonged sitting broken-up with either standing or light-intensity physical activi...
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#1Stacy A. ClemesH-Index: 25
Last.Jacqui TroughtonH-Index: 11
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Introduction: Heavy goods vehicle (HGV) drivers’ exhibit higher than nationally representative rates of obesity, and obesity-related co-morbidities, in comparison to other occupational groups. Their working environments are not conducive to a healthy lifestyle, yet there has been limited attention to health promotion efforts. We have developed a Structured Health Intervention For Truckers (the SHIFT programme), a multicomponent, theory-driven, health-behaviour intervention targeting physical act...
#1Scott A. Willis (NIHR: National Institute for Health Research)H-Index: 1
#2Jack A. Sargeant (NIHR: National Institute for Health Research)H-Index: 4
Last.James A. King (NIHR: National Institute for Health Research)H-Index: 16
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Background: Hepatokines such as fibroblast growth factor 21 (FGF21), leukocyte cell-derived chemotaxin 2 (LECT2), fetuin-A, fetuin-B and selenoprotein P (SeP) are liver-derived proteins which are modulated by chronic energy status and metabolic disease. Emerging data from rodent and cell models indicate that hepatokines may be sensitive to acute nutritional manipulation; however, data in humans are lacking. Objective: To investigate the influence of hyper-energetic, high-fat feeding on circulati...
1 CitationsSource
#1Aidan Q. Innes (MMU: Manchester Metropolitan University)
Last.Benjamin M. Kelly (MMU: Manchester Metropolitan University)H-Index: 1
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Background Finding effective intervention strategies to combat rising obesity levels could significantly reduce the burden that obesity and associated non-communicable diseases places on both individuals and the National Health Service. Methods In this parallel randomised-controlled trial, 76 participants who are overweight or obese (50 female) were given free access to a fitness centre for the duration of the 12-week intervention and randomised to one of three interventions. The commercial inte...
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#1Stacy A. Clemes (Lboro: Loughborough University)H-Index: 25
#2Veronica Varela-Mato (Lboro: Loughborough University)H-Index: 3
Last.James A. King (Lboro: Loughborough University)H-Index: 16
view all 13 authors...
Introduction Heavy goods vehicle (HGV) drivers exhibit higher than nationally representative rates of obesity, and obesity-related comorbidities, in comparison to other occupational groups. Their working environments are not conducive to a healthy lifestyle, yet there has been limited attention to health promotion efforts. We have developed a Structured Health Intervention For Truckers (the SHIFT programme), a multicomponent, theory-driven, health-behaviour intervention targeting physical activi...
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#1James L. Dorling (Pennington Biomedical Research Center)H-Index: 3
#2David J. Clayton (NTU: Nottingham Trent University)H-Index: 9
Last.David J. Stensel (National Health Service)H-Index: 27
view all 9 authors...
Background: The fat mass and obesity-associated gene (FTO) rs9939609 A-allele is associated with higher acyl-ghrelin (AG) concentrations, higher energy intake and obesity, though exercise may mitigate rs9939609 A-allele linked obesity risk. Butyrylcholinesterase (BChE) hydrolyses AG to des-acyl-ghrelin (DAG), potentially decreasing appetite. However, the effects of the FTO rs9939609 genotype and exercise on BChE activity, AG, DAG and energy intake are unknown. Objective: We hypothesized that ind...
1 CitationsSource
#1Fernanda R. Goltz (Lboro: Loughborough University)H-Index: 3
#2Alice E. Thackray (Lboro: Loughborough University)H-Index: 7
Last.David J. Stensel (Lboro: Loughborough University)H-Index: 27
view all 10 authors...
Abstract Background The fat mass and obesity-associated gene (FTO) rs9939609 A-allele has been associated with obesity risk. Although the exact mechanisms involved remain unknown, the FTO rs9939609 A-allele has been associated with an impaired postprandial suppression of appetite. Objectives To explore the influence of FTO rs9939609 genotype on fasting and postprandial appetite-related hormones and perceived appetite in a heterogeneous sample of men and women. Design 112 healthy men and women ag...
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#1Scott A. Willis (Lboro: Loughborough University)H-Index: 1
#2Jack A. Sargeant (Lboro: Loughborough University)H-Index: 4
Last.James A. King (Lboro: Loughborough University)H-Index: 16
view all 7 authors...
Fibroblast growth factor 21 (FGF21), follistatin and leukocyte cell-derived chemotaxin 2 (LECT2) are novel hepatokines that are modulated by metabolic stresses. This study investigated whether exer...
1 CitationsSource
#1Fernanda R. Goltz (National Health Service)H-Index: 3
#2Alice E. Thackray (National Health Service)H-Index: 7
Last.David J. Stensel (National Health Service)H-Index: 27
view all 9 authors...
Background: After meal ingestion, a series of coordinated hormone responses occur concomitantly with changes in perceived appetite. It is not known whether interindividual variability in appetite exists in response to a meal. Objectives: This study aimed to 1) assess the reproducibility of appetite responses to a meal; 2) quantify individual differences in responses; and 3) explore any moderating influence of the fat mass and obesity associated (FTO) gene. Methods: Using a replicated crossover d...
3 CitationsSource
Objective: To explore the risk of having musculoskeletal conditions (MSKs) associated with sitting and sleeping time during workdays, presenteeism, work engagement anxiety and depression in a sample of UK HGV drivers. Methods: 88 male drivers participated in this cross-sectional study. Binary logistic regression analyses were performed to explore the associations between two-or-more MSKs and common health risk factors. Results: Possessing two or more MSKs is associated with prolonged sitting tim...
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