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Klára Marečková
Central European Institute of Technology
Developmental psychologyPsychologyYoung adultMajor depressive disorderMood
13Publications
6H-index
155Citations
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Publications 15
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#1Ronald G. Garcia (Harvard University)H-Index: 20
#2Klára Marečková (Central European Institute of Technology)H-Index: 6
Last. Jill M. GoldsteinH-Index: 65
view all 8 authors...
Cardiac autonomic dysregulation has been implicated in the comorbidity of major psychiatric disorders and cardiovascular disease, potentially through dysregulation of physiological responses to negative stressful stimuli (here, shortened to stress response). Further, sex differences in these comorbidities are substantial. Here, we tested the hypothesis that mood- and sex-dependent alterations in brain circuitry implicated in the regulation of the stress response are associated with reduced perip...
1 CitationsSource
#1Klára MarečkováH-Index: 6
#2Erin W. DickieH-Index: 8
Last. Yuliya S. NikolovaH-Index: 13
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#1Klára Marečková (Central European Institute of Technology)H-Index: 6
#2Anja KlasnjaH-Index: 2
Last. Tomáš Paus (MIND Institute)H-Index: 86
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This study aimed to determine whether prenatal stress, measured by the number of stressful life events during the first 20 weeks of pregnancy, might relate to mood dysregulation and altered brain structure in young adulthood. Participants included 93 young adults from a community-based birth cohort from the Czech Republic. Information on prenatal stress exposure was collected from their mothers in 1990-1992. Magnetic resonance imaging (MRI) and mood-related data were collected from the young adu...
7 CitationsSource
#1Klára MarečkováH-Index: 6
#2Anja KlasnjaH-Index: 2
Last. Tomáš PausH-Index: 86
view all 6 authors...
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#1Klára Marečková (Central European Institute of Technology)H-Index: 6
#2Radek Mareček (Central European Institute of Technology)H-Index: 20
Last. Milan Brázdil (Central European Institute of Technology)H-Index: 26
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The main objective of this study was to investigate the impact of prenatal and early postnatal stress on hippocampal volume in young adulthood. In sharp contrast to numerous results in animal models, our data from a neuroimaging follow-up (n = 131) of a community-based birth cohort from the Czech Republic (European Longitudinal Study of Pregnancy and Childhood) showed that in typically developing young adults, hippocampal volume was not associated with birth weight, stressful life events during ...
4 CitationsSource
#1Klára Marečková (Masaryk University)H-Index: 6
#2Laura M. Holsen (Brigham and Women's Hospital)H-Index: 23
Last. Jill M. Goldstein (Harvard University)H-Index: 65
view all 8 authors...
Abstract Background Maladaptive responses to negative affective stimuli are pervasive, including clinically ill and healthy people, and men and women respond differently at neural and hormonal levels. Inspired by the Research Domain Criteria initiative, we used a transdiagnostic approach to investigate the impact of sex and dysphoric mood on neural-hormonal responses to negative affective stimuli. Methods Participants included 99 individuals with major depressive disorder, psychosis and healthy ...
6 CitationsSource
#1Klára Marečková (Brigham and Women's Hospital)H-Index: 6
#2Laura M. Holsen (Brigham and Women's Hospital)H-Index: 23
Last. Jill M. Goldstein (Harvard University)H-Index: 65
view all 8 authors...
Negative affective stimuli elicit behavioral and neural responses which vary on a continuum from adaptive to maladaptive, yet are typically investigated in a dichotomous manner (healthy controls vs. psychiatric diagnoses). This practice may limit our ability to fully capture variance from acute responses to negative affective stimuli to psychopathology at the extreme end. To address this, we conducted a functional magnetic resonance imaging study to examine the neural responses to negative valen...
11 CitationsSource
#1Klára Marečková (Masaryk University)H-Index: 6
#2Laura M. Holsen (Brigham and Women's Hospital)H-Index: 23
Last. Jill M. Goldstein (Brigham and Women's Hospital)H-Index: 65
view all 5 authors...
Inspired by the NIMH RDoC initiative to determine biosignatures associated with regulation of arousal and negative affect across psychiatric disorders, we used a mild visual stress task to conduct a functional magnetic resonance imaging (fMRI) study investigating the impact of depressed mood on stress circuitry function in major depressive disorder, psychosis and healthy controls ( n = 99). fMRI data were analyzed using SPM8 and task-related connectivity was assessed by generalized psychophysiol...
Source
#1Klára Marečková (University of Nottingham)H-Index: 6
#2M. Mallar Chakravarty (U of T: University of Toronto)H-Index: 44
Last. Tomáš Paus (University of Nottingham)H-Index: 86
view all 11 authors...
We used magnetic resonance (MR) images obtained in same-sex and opposite-sex dizygotic twins (n = 119, 8 years of age) to study possible effects of prenatal androgens on craniofacial features. Using a principal component analysis of 19 craniofacial landmarks placed on the MR images, we identified a principal component capturing craniofacial features that distinguished females with a presumed differential exposure to prenatal androgens by virtue of having a male (vs. a female) co-twin (Cohen’s d ...
4 CitationsSource
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