Match!
Grainne M. McAlonan
King's College London
189Publications
36H-index
5,272Citations
Publications 195
Newest
In the perinatal brain, regional cortical architecture and connectivity lay the foundations for functional circuits and emerging behaviour. Interruptions or atypical development during or before this period may therefore have long-lasting consequences. However, to be able to investigate these deviations, we need a measure of how this architecture evolves in the typically developing brain. To this end, in a large cohort of 241 term-born infants we used Magnetic Resonance Imaging to estimate corti...
Source
Abstract Down Syndrome (DS) is the most frequent genetic cause of intellectual disability with a wide spectrum of neurodevelopmental outcomes. At present, the relationship between structural brain morphology and the spectrum of cognitive phenotypes in DS, is not well understood. This study aimed to quantify the development of the fetal and neonatal brain in DS participants, with and without a congenital cardiac defect compared with a control population using dedicated, optimised and motion-corre...
Source
#1Chi Ho Chong (Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Qi Li (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 14
Last.Siu Yuen Chan (Li Ka Shing Faculty of Medicine, University of Hong Kong)H-Index: 16
view all 9 authors...
LRRC7 has been identified as a candidate gene for severe childhood emotional dysregulation. Direct experimental evidence for a role of LRRC7 in the disease is needed, as is a better understanding of its impact on neuronal structure and signaling, and hence potential treatment targets. Here, we generated and analyzed an Lrrc7 mutant mouse line. Consistent with a critical role of LRRC7 in emotional regulation, mutant mice had inappropriate juvenile aggressive behavior and significant anxiety-like ...
Source
Adults with autism spectrum disorder (ASD) are frequently prescribed selective serotonin reuptake inhibitors (SSRIs). However, there is limited evidence to support this practice. Therefore, it is crucial to understand the impact of SSRIs on brain function abnormalities in ASD. It has been suggested that some core symptoms in ASD are underpinned by deficits in executive functioning (EF). Hence, we investigated the role of the SSRI citalopram on EF networks in 19 right-handed adult males with ASD ...
Source
Abstract Fathers play a crucial role in their children’s socio-emotional and cognitive development. A plausible intermediate phenotype underlying this association is father’s impact on infant brain. However, research on the association between paternal caregiving and child brain biology is scarce, particularly during infancy. Thus, we used magnetic resonance imaging (MRI) to investigate the relationship between observed father–infant interactions, specifically paternal sensitivity, and regional ...
Source
Autism spectrum disorder (ASD) is a high cost neurodevelopmental condition; and there are currently no effective pharmacological treatments for its core symptoms. This has led some families and researchers to trial alternative remedies – including the non-intoxicating Cannabis sativa-derived compound cannabidivarin (CBDV). However, how CBDV affects the human brain is unknown. Previous (pre)clinical evidence suggests that CBDV may modulate brain excitatory-inhibitory systems, which are implicated...
Source
#1Dwaipayan Adhya (University of Cambridge)H-Index: 4
#2Vivek Swarup (UCLA: University of California, Los Angeles)H-Index: 15
Last.Simon Baron-Cohen (University of Cambridge)H-Index: 139
view all 21 authors...
Autism is a heterogenous collection of disorders with a complex molecular underpinning. Evidence from post mortem studies using adult brains have identified atypical co-expression of genes which may occur during the prenatal period. Recent studies using induced pluripotent stem cells (iPSCs) generated from autistic individuals have suggested that prenatal development is a critical period for the emergence of pathophysiology associated with this condition. However, how early during development th...
Source
#1Warre Cornish ('KCL': King's College London)
#2Nagy (University of Cambridge)
Last.Price
view all 12 authors...
Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-gamma (IFNγ), in offspring9s brains play a central role. IFNγ activates an antiviral cellular state, limiting viral entry and replication. In addition, IFNγ has been implicated in brain development. Here, we hypothesise that IFNγ-induced antiviral signalling contributes to molecular and cellular phenotypes associated with neurodevelopmental disorders. We find that transient IFNγ ...
Source
#1Paul Basil (BCM: Baylor College of Medicine)H-Index: 2
#2Qi Li (HKU: University of Hong Kong)H-Index: 14
Last.Pak C. Sham (HKU: University of Hong Kong)H-Index: 106
view all 4 authors...
Abstract DNA methylation is a dynamic epigenetic mark regulating gene function and are implicated in the pathophysiology of schizophrenia and autism. Environmental exposures such as inflammation and diet modify the epigenome and may explain why prenatal exposure to inflammation increase risk of neurodevelopmental disorders. This manuscript presents genome-wide DNA methylation data (GSE102942) generated from adult offspring brain prenatally exposed to Maternal Immune Activation (MIA). Methylome o...
Source
#1Charlotte M. Pretzsch ('KCL': King's College London)H-Index: 1
#2Bogdan I. Voinescu ('KCL': King's College London)H-Index: 7
Last.Grainne M. McAlonanH-Index: 36
view all 11 authors...
Background:The potential benefits of cannabis and its major non-intoxicating component cannabidiol (CBD) are attracting attention, including as a potential treatment in neurodevelopmental disorders...
1 CitationsSource
12345678910