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Ketan M. Ranch
Uka Tarsadia University
15Publications
6H-index
144Citations
Publications 16
Newest
Abstract Lidocaine is widely used as a local anaesthetic in the clinical practice to manage pre- and post-operative pain, skin burns, etc. However, the short duration of action (
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#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Riya J. Parmar (Uka Tarsadia University)H-Index: 1
Last.Dinesh O. Shah (UF: University of Florida)H-Index: 53
view all 9 authors...
Abstract The optical and swelling properties of gatifloxacin-loaded contact lens decrease owing to the precipitation of gatifloxacin (on hydration) in the matrix structure of the contact lens. This paper focuses on the use of Pluronic F68 both inside and outside (in the packaging solution) the contact lens to form micelles to dissolve the gatifloxacin precipitates and not limited to sustain the release of gatifloxacin. The aim of this study was to screen the critical variables affecting the opti...
1 CitationsSource
#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Rahul Patil (Uka Tarsadia University)H-Index: 3
Last.Dinesh O. ShahH-Index: 53
view all 9 authors...
Abstract Contact lenses are ideally suited for extended drug delivery to the ocular tissues, but incorporation of any particulate system affects the critical properties of the contact lens. Timolol loading by the conventional soaking method does not significantly alter the critical properties of the contact lens. However, there are challenges of low drug loading and high burst release. This research work aimed to investigate the effect of gold nanoparticles (GNPs) on loading and its release kine...
2 CitationsSource
#1Ketan M. Ranch (Uka Tarsadia University)H-Index: 6
#2Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
Last.Dinesh O. ShahH-Index: 53
view all 6 authors...
Abstract The aim of the present research work was to formulate, optimize and evaluate the in-situ gel for the ophthalmic drug delivery using the combination of gellan gum and carbopol 934P. The Box-Behnken design was applied to optimize the concentration of gellan gum (X1), carbopol 934P (X2) and benzododecenium bromide (X3) to achieve the maximum viscosity [at physiological condition; 35 °C, pH 7.4, and simulated tear fluid (STF)], mucoadhesive strength, permeability coefficient and sustained r...
6 CitationsSource
Cancer is a disease characterised by uncontrolled multiplication and spread of abnormal forms of the body's own cells. Methotrexate sodium is an antineoplastic agent of the anti-metabolite class of chemotherapy drugs, which inhibits dihydrofolate reductase and blocking the conversion of dihydrofolic acid to tetrahydrofolic acid. Metal nanoparticles such as gold nanoparticles are having a smaller size, more stable and relatively narrow size distribution which provide opportunities for effective a...
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#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Sulabh S. Singhania (Uka Tarsadia University)H-Index: 2
Last.Dinesh O. ShahH-Index: 53
view all 8 authors...
Abstract Currently, bacterial conjunctivitis is treated by frequent administration of antibiotic eye drop solutions, which is tedious and patient noncompliant. Contact lenses could be ideal medical devices to sustain the release of ophthalmic drugs, but the incorporation of the latter can alter the optical and physical properties of the lenses. In addition, many contact lens users have reported the pink eye syndrome, making them unsuitable as ocular medical devices. In the present study, we have...
8 CitationsSource
#1Jignesh P. Raval (Uka Tarsadia University)H-Index: 2
#2Dharmesh R. Chejara (Uka Tarsadia University)
Last.Parth Joshi (Uka Tarsadia University)H-Index: 1
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Abstract Doxycycline hyclate (DH), one of the bacteriostatic drugs is an effective ingredient against many bacteria. It is used to treat bacterial infections such as urinary tract infection, upper respiratory tract infection, acne, gonorrhea, chlamydia and anthrax, etc. DH generally works by stopping protein synthesis of the particular bacteria as well as protozoans. Presently, several drug delivery systems based on micro particulates/nano particulates systems are available. In this chapter, pha...
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#1Ankita R. Desai (Uka Tarsadia University)H-Index: 6
#2Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
Last.Dinesh O. ShahH-Index: 53
view all 7 authors...
Glaucoma is a chronic disease, which is currently treated using frequent high dose applications of an eye drop solution; this method is tedious, and most of patients are non-compliant to it. Contact lenses are emerging as a convenient option to sustain the release of ophthalmic drugs. However, the incorporation of a drug/formulation changes the optical and physical properties of contact lenses. Contact lens users have also reported pink eye syndrome; this makes contact lenses unsuitable to be ac...
6 CitationsSource
#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Harsh H. Choksi (Uka Tarsadia University)H-Index: 3
Last.Dinesh O. ShahH-Index: 53
view all 7 authors...
Abstract In the present work a novel cyclosporine-loaded Eudragit S100 (pH-sensitive) nanoparticles-laden contact lenses were designed to provide sustained release of cyclosporine at therapeutic rates, without leaching of drug during sterilization and storage period (shelf life). The nanoparticles were prepared by Quasi-emulsion solvent diffusion technique using different weight ratios of cyclosporine to Eudragit S100. The contact lenses with direct drug entrapment were also fabricated (DL-50) f...
13 CitationsSource
#1Furqan A. Maulvi (Uka Tarsadia University)H-Index: 9
#2Ankita R. Desai (Uka Tarsadia University)H-Index: 6
Last.Dinesh O. ShahH-Index: 53
view all 7 authors...
Abstract The effect of surfactant chain lengths [sodium caprylate (C 8 ), Tween 20 (C 12 ), Tween 80 (C 18 )] and the molecular weight of block copolymers [Pluronic F68 and Pluronic F 127] were studied to determine the stability of the microemulsion and its effect on release kinetics from cyclosporine-loaded microemulsion-laden hydrogel contact lenses in this work. Globule size and dilution tests (transmittance) suggested that the stability of the microemulsion increases with increase in the car...
17 CitationsSource
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