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Cristina Romei
University of Pisa
EndocrinologyCarcinomaThyroid cancerThyroidMedicine
144Publications
37H-index
5,542Citations
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Publications 146
Newest
#1Gisella FiglioliH-Index: 7
#2Aleksandra KöhlerH-Index: 3
Last. Federica GemignaniH-Index: 31
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#1Carlotta GianiH-Index: 6
#2Liborio TorregrossaH-Index: 17
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To compare the epidemiological, clinical, and pathological features of follicular (FVPTC) and classical (CVPTC) variants of papillary thyroid cancer and to correlate their outcomes according to different features. Retrospective analysis of FVPTC and CVPTC patients selected at the moment of surgical treatment from 1999 to 2004, with a median follow-up of 15 years. Several significant differences were found between FVPTC and CVPTC such as the mean age at diagnosis, the presence of tumor capsule, t...
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#1Laura ValerioH-Index: 6
#2Valeria BotticiH-Index: 18
Last. Rossella EliseiH-Index: 66
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#1Cristina RomeiH-Index: 37
#2Raffaele CiampiH-Index: 22
Last. Rossella EliseiH-Index: 2
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#1Raffaele CiampiH-Index: 22
#2Cristina RomeiH-Index: 37
Last. Rossella EliseiH-Index: 66
view all 12 authors...
Summary Sporadic Medullary Thyroid Carcinoma (sMTC) is a rare but aggressive thyroid tumor. RET and RAS genes are present in about 50%–80% of cases, but most of the remaining cases are still orphan of a genetic driver. We studied the largest series of sMTC by deep sequencing to define the mutational landscape. With this methodology we greatly reduced the number of RET- or RAS-negative cases and we confirmed the central role of RET and RAS mutations. Moreover, we highlighted the bad prognostic ro...
2 CitationsSource
#1Rossella EliseiH-Index: 66
#2Alessia TacitoH-Index: 8
Last. Cristina RomeiH-Index: 37
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Background: Pathogenic germline mutations affecting the RET proto-oncogene underlie the development of hereditary medullary thyroid carcinoma (MTC). The aims of this study were to evaluate the prevalence of germline RET mutations in a large series of MTC, collected over the last 25 years, and to reappraise their clinical significance. Methods: We performed RET genetic screening in 2031 Italian subjects: patients who presented with sporadic (n = 1264) or hereditary (n = 117) MTC, plus 650 relativ...
1 CitationsSource
#1Teresa Ramone (UniPi: University of Pisa)H-Index: 1
#2Cristina Romei (UniPi: University of Pisa)H-Index: 37
Last. Rossella Elisei (UniPi: University of Pisa)H-Index: 66
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Pourposes We investigated the expression of RET9 and RET51 isoforms in medullary (MTC), papillary (PTC) thyroid carcinoma, normal thyroid tissues, and pheochromocytoma (PHEO) to verify if these isoforms are present also in follicular thyroid cell-derived tissues, and if there is a differential expression of RET9 and RET51 in MTC.
Source
#1Rossella Elisei (UniPi: University of Pisa)H-Index: 66
#2Antonio Matrone (UniPi: University of Pisa)H-Index: 7
Last. Cristina Romei (UniPi: University of Pisa)H-Index: 37
view all 15 authors...
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#1Rossella Elisei (UniPi: University of Pisa)H-Index: 66
#2Valeria Bottici (UniPi: University of Pisa)H-Index: 18
Last. Cristina Romei (UniPi: University of Pisa)H-Index: 37
view all 7 authors...
Abstract Medullary thyroid cancer (MTC) is a rare thyroid tumor whose prevalence is 3–5% among all thyroid tumors. The pathogenesis of MTC is mainly related to germline or somatic RET activating point mutations that are causative of hereditary and sporadic cases, respectively. Hereditary MTC can occur as multiple endocrine neoplasia type 2A (MEN 2A), type 2B (MEN 2B) and familial MTC (FMTC) that differ for the association with other endocrine neoplasia. Germline RET point mutations are prevalent...
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#1Rossella EliseiH-Index: 2
#2Valeria BotticiH-Index: 18
Last. Cristina RomeiH-Index: 37
view all 7 authors...
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