Meher Preethi Boorgula
University of Colorado Denver
ImmunologyGeneticsMedicineLocus (genetics)Biology
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Publications 26
#1Lianghua Bin (National Jewish Health)
#1Lianghua BinH-Index: 10
Last. Kathleen C. BarnesH-Index: 59
view all 12 authors...
#1Nicolas Vince (French Institute of Health and Medical Research)H-Index: 8
#2Sophie Limou (University of Nantes)H-Index: 1
Last. Sameer Chavan (University of Colorado Denver)H-Index: 3
view all 31 authors...
Abstract Background Asthma is a complex chronic inflammatory disease of the airways. Association studies between HLA and asthma were first reported in the 1970’s, and yet, the precise role of HLA alleles in asthma is not fully understood. Numerous genome-wide association studies were recently conducted on asthma, but were always limited to simple genetic markers (SNPs) and not complex HLA gene polymorphisms (alleles/haplotypes), therefore not capturing the biological relevance of this complex lo...
#1Priyadarshini Kachroo (Brigham and Women's Hospital)H-Index: 4
#2Julian Hecker (Harvard University)H-Index: 5
Last. Sebastian ZoellnerH-Index: 3
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ABSTRACT Background Asthma is a common respiratory disorder with a highly heterogeneous nature that remains poorly understood. The objective was to identify regions of common genetic variation contributing to lung function in individuals diagnosed with asthma, utilizing whole-genome sequencing (WGS) data. Methods WGS data were generated for 1,053 individuals from trios and extended pedigrees participating in the family-based ‘Genetic Epidemiology of Asthma in Costa Rica’ study. Asthma affection ...
#1Meher Preethi Boorgula (University of Colorado Denver)H-Index: 9
#2Margaret A. Taub (Johns Hopkins University)H-Index: 18
Last. Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
view all 21 authors...
Although epigenetic mechanisms are important risk factors for allergic disease, few studies have evaluated DNA methylation differences associated with atopic dermatitis (AD), and none has focused on AD with eczema herpeticum (ADEH+). We will determine how methylation varies in AD individuals with/without EH and associated traits. We modeled differences in genome-wide DNA methylation in whole blood cells from 90 ADEH+, 83 ADEH−, and 84 non-atopic, healthy control subjects, replicating in 36 ADEH+...
#1Alexandra Winters (Johns Hopkins University)
#2Henry T. Bahnson (BRI: Benaroya Research Institute)H-Index: 43
Last. Rasika A. Mathias (Johns Hopkins University)H-Index: 44
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#1Michelle Daya (University of Colorado Denver)H-Index: 10
#2Nicholas Rafaels (University of Colorado Denver)H-Index: 26
Last. Kathleen C. Barnes (University of Colorado Denver)H-Index: 59
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Asthma is a complex disease with striking disparities across racial and ethnic groups. Despite its relatively high burden, representation of individuals of African ancestry in asthma genome-wide association studies (GWAS) has been inadequate, and true associations in these underrepresented minority groups have been inconclusive. We report the results of a genome-wide meta-analysis from the Consortium on Asthma among African Ancestry Populations (CAAPA; 7009 asthma cases, 7645 controls). We find ...
3 CitationsSource
#1Ayobami T. Akenroye (Johns Hopkins University)H-Index: 1
#2Michelle Daya (CU: University of Colorado Boulder)H-Index: 10
Last. Rasika A. Mathias (Johns Hopkins University)H-Index: 44
view all 10 authors...
#1Michelle Daya (CU: University of Colorado Boulder)H-Index: 10
#2Nicholas Rafaels (CU: University of Colorado Boulder)H-Index: 26
Last. Kathleen C. Barnes (CU: University of Colorado Boulder)H-Index: 59
view all 65 authors...