Susi Keck
Humboldt University of Berlin
Publications 4
#1Diana Poppek (HHU: University of Düsseldorf)H-Index: 4
#2Susi Keck (Humboldt University of Berlin)H-Index: 2
Last.Tilman Grune (Humboldt University of Berlin)H-Index: 70
view all 8 authors...
Hyperphosphorylated tau proteins accumulate in the paired helical filaments of neurofibrillary tangles seen in such tauopathies as Alzheimer's disease. In the present paper we show that tau turnover is dependent on degradation by the proteasome (inhibited by MG132) in HT22 neuronal cells. Recombinant human tau was rapidly degraded by the 20 S proteasome in vitro, but tau phosphorylation by GSK3β (glycogen synthase kinase 3β) significantly inhibited proteolysis. Tau phosphorylation was increased ...
117 CitationsSource
#1Diana PoppekH-Index: 4
#2Susi KeckH-Index: 2
Last.Tilman GruneH-Index: 70
view all 5 authors...
#1Susi KeckH-Index: 2
Last.Tilman GruneH-Index: 70
view all 4 authors...
#1Susi KeckH-Index: 2
#2Robert NitschH-Index: 58
Last.Oliver UllrichH-Index: 37
view all 4 authors...
Alzheimer's disease (AD) is characterized neuropathologically by intracellular neurofibrillary tangles (NFTs) formed of tau-based paired helical filaments (PHFs) and extracellular β-amyloid plaques. The degree of Alzheimer dementia correlates with the severity of PHFs and NFTs. As an intraneuronal accumulation of oxidatively damaged proteins has been found in the brains of patients with AD, a dysfunction of the proteasomal system, which degrades damaged proteins, has been assumed to cause protei...
319 CitationsSource