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Neil Hoa
University of California, Irvine
60Publications
16H-index
1,472Citations
Publications 60
Newest
#1Amrita AhluwaliaH-Index: 52
#2Neil HoaH-Index: 16
Last.Andrzej S. Tarnawski (UCI: University of California, Irvine)H-Index: 55
view all 4 authors...
BACKGROUND & AIMS: Non-steroidal anti-inflammatory drugs (NSAIDs) such as diclofenac (DFN) and indomethacin (INDO) are extensively used worldwide. Their main side effects are injury of gastrointest...
Source
#1Amrita AhluwaliaH-Index: 52
#2Michael K. Jones (UCI: University of California, Irvine)H-Index: 25
Last.Andrzej S. Tarnawski (UCI: University of California, Irvine)H-Index: 55
view all 4 authors...
Source
#1Amrita AhluwaliaH-Index: 52
#2Michael K. JonesH-Index: 25
Last.Andrzej S. TarnawskiH-Index: 55
view all 6 authors...
Source
#1Amrita AhluwaliaH-Index: 52
#2Iwona M. Brzozowska (Jagiellonian University Medical College)H-Index: 10
Last.Andrzej S. Tarnawski (UCI: University of California, Irvine)H-Index: 55
view all 5 authors...
We read with interest the paper of Suofu et al. (1), demonstrating that neuronal mitochondria produce melatonin, which upon binding to its melatonin type 1 (MT1) receptor on the mitochondrial membrane (MM) inhibits cytochrome c release, caspase activation, and apoptosis. We commend the authors on their thorough investigation but wish to point out some major questions: ( i ) Is the presence of the MT1 receptor in mitochondria limited to the neuronal cells or may it also apply to other cells, for ...
9 CitationsSource
#1Amrita AhluwaliaH-Index: 52
#2Michael K. Jones (UCI: University of California, Irvine)H-Index: 25
Last.Andrzej S. Tarnawski (UCI: University of California, Irvine)H-Index: 55
view all 6 authors...
Background & Aims Aging gastric mucosa has increased susceptibility to injury and delayed healing owing to impaired angiogenesis, but the mechanisms are not fully known. We examined whether impairment of angiogenesis in aging gastric mucosa is caused by deficiency of nerve growth factor (NGF) in gastric endothelial cells (ECs), and whether NGF therapy could reverse this impairment. Methods In gastric mucosal ECs (GECs) isolated from young and aging rats we examined the following: (1) in vitro an...
2 CitationsSource
#1Amrita AhluwaliaH-Index: 52
#2Michael K. Jones (UCI: University of California, Irvine)H-Index: 25
Last.Andrzej S. Tarnawski (UCI: University of California, Irvine)H-Index: 55
view all 4 authors...
Abstract Background/aims Endothelial cells (ECs) lining blood vessels are critical for delivery of oxygen and nutrients to all tissues and organs and play a crucial role in the regeneration of blood vessel following tissue injury. ECs are also major targets of injury by a variety of noxious factors [ e . g ., ethanol and nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, indomethacin, diclofenac], especially in gastric mucosa that has direct exposure to these agents. In this study, w...
4 CitationsSource
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. Jadus (University of California, Berkeley)H-Index: 24
view all 7 authors...
ABSTRACTObjective: Temozolomide (TMZ) improves Glioblastoma Multiforme (GBM) patient survival. The invasive behavior of the glioma cells is the cause of GBM relapse. The glioma BK ion channel (gBK) may provide glioma cells with a mechanism to invade surrounding tissue. gBK contains epitopes that cytolytic T lymphocytes (CTLs) can recognize and kill glioma cells. Fascin-1 is an actin crosslinking molecule that supports microvilli; these membrane protrusions provide a physical defense against CTLs...
1 CitationsSource
#1Lisheng GeH-Index: 9
#2Neil HoaH-Index: 16
Last.Martin R. Jadus (VA: United States Department of Veterans Affairs)H-Index: 24
view all 7 authors...
Objective: Our group has previously observed that in patients with small-cell lung cancers (SCLCs), the expression of a tumorantigen, glioma big potassium (gBK) ion channel, is higher at the time of death than when the cancer is first treated by surgicalresection. This study aimed to determine whether this dichotomy was common in other potential lung tumor antigens byexamining the same patient samples using our more extensive profile analysis of tumor-antigen precursor protein (TAPP). Wethen tes...
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#1Benjamin H. Beck (UAB: University of Alabama at Birmingham)H-Index: 18
#2Hyunggoon Kim (UAB: University of Alabama at Birmingham)H-Index: 1
Last.Lawrence S. Lamb (UAB: University of Alabama at Birmingham)H-Index: 1
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Human γδ T cells are potent effectors against glioma cell lines in vitro and in human/mouse xenograft models of glioblastoma, however, this effect has not been investigated in an immunocompetent mouse model. In this report, we established GL261 intracranial gliomas in syngeneic WT C57BL/6 mice and measured circulating γδ T cell count, phenotype, Vγ/Vδ repertoire, tumor histopathology, NKG2D ligands expression, and T cell invasion at day 10–12 post-injection and at end stage. Circulating γδ T cel...
2 CitationsSource
#1Neil HoaH-Index: 16
#2Lisheng GeH-Index: 9
Last.Martin R. JadusH-Index: 24
view all 9 authors...
Cancer cells derived from Glioblastoma multiforme possess membranous protrusions allowing these cells to infiltrate surrounding tissue, while resisting lymphocyte cytotoxicity. Microvilli and filopodia are supported by actin filaments cross-linked by fascin. Fascin-1 was genetically silenced within human U251 glioma cells; these knock-down glioma cells lost their microvilli/filopodia. The doubling time of these fascin-1 knock-down cells was doubled that of shRNA control U251 cells. Fascin-1 knoc...
7 Citations
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