Ziv Harel
International Council for the Exploration of the Sea
Intensive care medicineAcute kidney injuryPopulationDiabetes mellitusMedicine
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Publications 80
#1Kevin M. Hill (U of O: University of Ottawa)H-Index: 1
Last. Eric McArthurH-Index: 18
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Importance Clarithromycin is a commonly prescribed antibiotic associated with higher levels of direct oral anticoagulants (DOACs) in the blood, with the potential to increase the risk of hemorrhage. Objective To assess the 30-day risk of a hospital admission with hemorrhage after coprescription of clarithromycin compared with azithromycin among older adults taking a DOAC. Design, Setting, and Participants This population-based, retrospective cohort study was conducted among adults of advanced ag...
#1Alexander Jf Davidson (U of T: University of Toronto)
#2Alison L. Park (U of T: University of Toronto)H-Index: 9
Last. Joel G. RayH-Index: 34
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Background The relation between prepregnancy average glucose concentration and a woman’s risk of severe maternal morbidity (SMM) is unknown. The current study evaluated whether an elevated preconception hemoglobin A1c (A1c) is associated with SMM or maternal death among women with and without known prepregnancy diabetes mellitus (DM). Methods and findings A population-based cohort study was completed in Ontario, Canada, where there is universal healthcare. The main cohort included 31,225 women a...
#1Mohammed Somaili (McMaster University)
#2Nivethika Jeyakumar (International Council for the Exploration of the Sea)H-Index: 1
Last. Amber O. Molnar (McMaster University)H-Index: 11
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Abstract Background Kidney transplant recipients (KTRs) are routinely excluded from direct oral anticoagulant (DOAC) trials. Given the lack of safety and efficacy data in this population, we examined real-world prescribing practices of DOACs in KTRs. Methods We conducted a retrospective cohort study using linked administrative data sets in Ontario, Canada. All adult KTRs (n = 5580) from June 23, 2009, to March 31, 2017, were included. The primary outcomes were the first prescription for a DOAC o...
#1Ziv Harel (St. Michael's Hospital)H-Index: 17
#2Alison L. Park (International Council for the Exploration of the Sea)H-Index: 1
Last. Joel G. Ray (St. Michael's Hospital)H-Index: 29
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#1Justin Ashley (U of O: University of Ottawa)
#2Eric McArthurH-Index: 18
Last. Doug Manuel (U of O: University of Ottawa)H-Index: 11
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Abstract Rationale & Objective Evidence for efficacy of direct oral anticoagulants (DOACs) to prevent cardiovascular events and mortality in older individuals with a low estimated glomerular filtration rate (eGFR) is lacking. We sought to characterize the association of oral anticoagulant use with cardiovascular morbidity in elderly patients with or without reductions in eGFR, comparing DOACs to vitamin K antagonists (VKA). Study Design Population-based retrospective cohort study. Settings and P...
1 CitationsSource
BACKGROUND: Regulatory agencies warn about the risk of acute kidney injury (AKI) after the initiation of sodium-glucose cotransporter-2 (SGLT2) inhibitors. Our objective was to quantify the 90-day risk of AKI in older adults after initiation of SGLT2 inhibitors in routine clinical practice. METHODS: We conducted a population-based retrospective cohort study in Ontario, Canada, involving adults with diabetes who were aged 66 years or older and who were newly dispensed either an SGLT2 inhibitor or...
2 CitationsSource
#1Alison Thomas (U of T: University of Toronto)H-Index: 1
#2Samuel A. Silver (Queen's University)H-Index: 13
Last. Ron WaldH-Index: 44
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Rationale & Objective Surveillance blood work is routinely performed in maintenance hemodialysis (HD) recipients. Although more frequent blood testing may confer better outcomes, there is little evidence to support any particular monitoring interval. Study Design Retrospective population-based cohort study. Setting & Participants All prevalent HD recipients in Ontario, Canada, as of April 1, 2011, and a cohort of incident patients commencing maintenance HD in Ontario, Canada, between April 1, 20...
1 CitationsSource
#1Samuel A. Silver (Queen's University)H-Index: 13
#2Sarah E. Bota (International Council for the Exploration of the Sea)H-Index: 5
Last. Ron Wald (International Council for the Exploration of the Sea)H-Index: 44
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Background and objectives It is uncertain whether primary care physician continuity of care associates with a lower risk of death and hospitalization among patients transitioning to maintenance dialysis. Design, setting, participants, & measurements Using provincial-linked administrative databases in Ontario, Canada, we conducted a population-based study of incident patients who initiated maintenance dialysis between 2005 and 2014 and survived for at least 90 days. We defined high primary care p...
1 CitationsSource
#1Daniel Blum (JGH: Jewish General Hospital)H-Index: 1
#1Daniel Blum (St. Michael's Hospital)H-Index: 1
Last. Ron Wald (St. Michael's Hospital)H-Index: 44
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Abstract Background Studies have shown that achieving a time in therapeutic range (TTR) for warfarin of greater than 60% is associated with a lower risk of bleeding. However, many patients on hemodialysis (HD) do not achieve this target. Local Problem We audited TTR achievement at the in-center HD unit of our hospital in 2017 and found that only 40% of patients had achieved a TTR>60%. Project Aims We aimed to improve the percentage of HD patients achieving target TTR within two years. Interventi...
#1Ron Wald (U of T: University of Toronto)H-Index: 44
#2Paul Dorian (U of T: University of Toronto)H-Index: 77
Last. Ziv Harel (U of T: University of Toronto)H-Index: 17
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1 CitationsSource