Sameer Soi
University of Pennsylvania
Genome-wide association studyGeneticsBioinformaticsPopulation geneticsBiology
What is this?
Publications 11
#1Laura B. Scheinfeldt (UPenn: University of Pennsylvania)H-Index: 14
#2Sameer Soi (UPenn: University of Pennsylvania)H-Index: 6
Last. Sarah A. Tishkoff (UPenn: University of Pennsylvania)H-Index: 54
view all 17 authors...
Anatomically modern humans arose in Africa ∼300,000 years ago, but the demographic and adaptive histories of African populations are not well-characterized. Here, we have generated a genome-wide dataset from 840 Africans, residing in western, eastern, southern, and northern Africa, belonging to 50 ethnicities, and speaking languages belonging to four language families. In addition to agriculturalists and pastoralists, our study includes 16 populations that practice, or until recently have practi...
5 CitationsSource
#1Matthew T. McMillan (Mayo Clinic)H-Index: 17
#2Sameer SoiH-Index: 6
Last. Charles M. VollmerH-Index: 40
view all 27 authors...
Objective:To evaluate surgical performance in pancreatoduodenectomy using clinically relevant postoperative pancreatic fistula (CR-POPF) occurrence as a quality indicator.Background:Accurate assessment of surgeon and institutional performance requires (1) standardized definitions for the outcome of
46 CitationsSource
#1Sameer SoiH-Index: 6
#1Matthew T. McMillan (UPenn: University of Pennsylvania)H-Index: 17
#2Sameer Soi (UPenn: University of Pennsylvania)H-Index: 6
Last. Charles M. Vollmer (UPenn: University of Pennsylvania)H-Index: 40
view all 3 authors...
#1Joseph P. Jarvis (UPenn: University of Pennsylvania)H-Index: 13
#2Laura B. Scheinfeldt (UPenn: University of Pennsylvania)H-Index: 14
Last. Sarah A. Tishkoff (UPenn: University of Pennsylvania)H-Index: 54
view all 12 authors...
African Pygmy groups show a distinctive pattern of phenotypic variation, including short stature, which is thought to reflect past adaptation to a tropical environment. Here, we analyze Illumina 1M SNP array data in three Western Pygmy populations from Cameroon and three neighboring Bantu-speaking agricultural populations with whom they have admixed. We infer genome-wide ancestry, scan for signals of positive selection, and perform targeted genetic association with measured height variation. We ...
84 CitationsSource
#1Laura B. Scheinfeldt (UPenn: University of Pennsylvania)H-Index: 14
#2Sameer Soi (UPenn: University of Pennsylvania)H-Index: 6
Last. Sarah A. Tishkoff (UPenn: University of Pennsylvania)H-Index: 54
view all 11 authors...
Background Genomic analysis of high-altitude populations residing in the Andes and Tibet has revealed several candidate loci for involvement in high-altitude adaptation, a subset of which have also been shown to be associated with hemoglobin levels, including EPAS1, EGLN1, and PPARA, which play a role in the HIF-1 pathway. Here, we have extended this work to high- and low-altitude populations living in Ethiopia, for which we have measured hemoglobin levels. We genotyped the Illumina 1M SNP array...
172 CitationsSource
#1Drew G. Michael (WashU: Washington University in St. Louis)H-Index: 10
#2Sameer Soi (UPenn: University of Pennsylvania)H-Index: 6
Last. John A. Chiorini (NIH: National Institutes of Health)H-Index: 30
view all 8 authors...
Oral Diseases (2011) 17, 653–661 Objective: We hypothesized that differential mRNA transcription between the sexes may be linked to the 9:1 female-to-male gender-related relative risk for the development of Sjogren’s syndrome (SS), an autoimmune disease that leads to inflammation and dysfunction in the lachrymal and salivary glands. Subjects and Methods: RNA from minor salivary glands was collected from nine healthy volunteers (four men and five women) and analyzed using the Agilent 4 × 44K huma...
11 CitationsSource
#1Sarah A. Tishkoff (UPenn: University of Pennsylvania)H-Index: 54
#2Michael C. Campbell (UPenn: University of Pennsylvania)H-Index: 8
Last. Sameer Soi (UPenn: University of Pennsylvania)H-Index: 6
view all 9 authors...
Africa contains the greatest levels of human genetic variation and is the source of the worldwide range expansion of all modern humans. However, relatively little is known about genomic variation in ethnically diverse African populations. Knowledge of genetic structure within Africa has important implications for the design and implementation of disease association studies in Africans and in African Americans, and for reconstructing modern human origins. In addition, studies of genetic adaptatio...
We would like to first point out that we never interpreted any genetic data in our review article to support a Middle Eastern or European origin for the Fulani (1). We agree with Winters that the Fulani do not originate from the Middle East or Europe (2). Furthermore, we do not maintain that there is a predominance of Eurasian markers in the Fulani; we merely point out that there is some evidence of shared recent ancestry (i.e., gene flow) between the Fulani and Eurasian populations … 1To whom c...
#2Sameer SoiH-Index: 6
Last. Sarah A. Tishkoff (UPenn: University of Pennsylvania)H-Index: 54
view all 3 authors...
Although Africa is the origin of modern humans, the pattern and distribution of genetic variation and correlations with cultural and linguistic diversity in Africa have been understudied. Recent advances in genomic technology, however, have led to genomewide studies of African samples. In this article, we discuss genetic variation in African populations contextualized with what is known about archaeological and linguistic variation. What emerges from this review is the importance of using indepe...
81 CitationsSource