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Xiao Hui Liao
University of Chicago
Thyroid hormone receptorEndocrinologyThyroidHormoneBiology
75Publications
30H-index
3,659Citations
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Publications 74
Newest
#1Dionysios V. Chartoumpekis (University of Patras)H-Index: 13
#2Panos G. Ziros (UNIL: University of Lausanne)H-Index: 16
Last. Gerasimos P. Sykiotis (UNIL: University of Lausanne)H-Index: 27
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#1Monica Malheiros França (U of C: University of Chicago)
#2Xiao Hui Liao (U of C: University of Chicago)H-Index: 30
Last. M DumitrescuAlexandra (U of C: University of Chicago)H-Index: 26
view all 7 authors...
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#1Haruki Fujisawa (U of C: University of Chicago)H-Index: 2
#2Manassawee Korwutthikulrangsri (MU: Mahidol University)
Last. M DumitrescuAlexandra (U of C: University of Chicago)H-Index: 26
view all 5 authors...
Selenocysteine insertion sequence binding protein 2, SBP2 (SECISBP2), is required for selenoprotein synthesis. Partial SBP2 deficiency syndrome manifests characteristic thyroid function tests. The Sbp2 deficiency mouse model, Sbp2 iCKO, replicates this thyroid phenotype and was used for pathophysiologic investigations. As selenoproteins have antioxidative role in thyroid gland function, their deficiencies have potential to affect thyroid hormone (TH) synthesis. Sbp2 iCKO mice had larger thyroids...
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#1Jiao Fu (U of C: University of Chicago)H-Index: 4
#2Manassawee Korwutthikulrangsri (MU: Mahidol University)
Last. M DumitrescuAlexandra (U of C: University of Chicago)H-Index: 26
view all 8 authors...
Mutations in the cell-membrane thyroid hormone (TH) transporter MCT8 produce severe neuropsychomotor defects and characteristic thyroid function tests (TFT) abnormalities. Two children with mild ne...
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#1Jiao Fu (U of C: University of Chicago)H-Index: 4
#2Manassawee Korwutthikulrangsri (MU: Mahidol University)
Last. E WeissRoy (UM: University of Miami)H-Index: 53
view all 11 authors...
CONTEXT: Selenocysteine insertion sequence binding protein 2 (SECISBP2, SBP2) is an essential factor for selenoprotein synthesis. Individuals with SBP2 defects have characteristic thyroid function test (TFT) abnormalities resulting from deficiencies in the selenoenzymes deiodinases. Eight families with recessive SBP2 gene mutations have been reported to date. We report 2 families with inherited defect in thyroid hormone metabolism caused by 4 novel compound heterozygous mutations in the SBP2 gen...
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#1GriecoGiuseppina (UCL: Université catholique de Louvain)
#1Giuseppina Grieco (UCL: Université catholique de Louvain)H-Index: 3
Last. Christophe E. PierreuxH-Index: 31
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BACKGROUND: The production of thyroid hormones (T3, T4) depends on the organization of the thyroid in follicles, which are lined by a monolayer of thyrocytes with strict apico-basal polarity. This ...
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#1Soledad Bárez-López (CSIC: Spanish National Research Council)H-Index: 6
#1Soledad Bárez-López (CSIC: Spanish National Research Council)H-Index: 6
Last. Ana Guadaño-Ferraz (CSIC: Spanish National Research Council)H-Index: 18
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Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers. The use of TH analogs, such as triiodothyroacetic acid (TRIAC), that can potentially access the brain in the absence of MCT8 and restore at least a subset of cerebral TH actions could improve the neurologic...
2 CitationsSource
#1Hannah Kohler (University of Duisburg-Essen)
#1KohlerHannah (University of Duisburg-Essen)
Last. C MoellerLars (University of Duisburg-Essen)
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Background: Radioiodine refractory dedifferentiated thyroid cancer is a major clinical challenge. Anaplastic lymphoma kinase (ALK) mutations with increased ALK activity, especially fusion genes, ha...
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#1Hakan CangulH-Index: 10
#2Xiao Hui LiaoH-Index: 30
Last. Nadia SchoenmakersH-Index: 17
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: Defects in genes mediating thyroid hormone biosynthesis result in dyshormonogenic congenital hypothyroidism (CH). Here, we report homozygous truncating mutations in SLC26A7 in 6 unrelated families with goitrous CH and show that goitrous hypothyroidism also occurs in Slc26a7-null mice. In both species, the gene is expressed predominantly in the thyroid gland, and loss of function is associated with impaired availability of iodine for thyroid hormone synthesis, partially corrected in mice by iod...
4 CitationsSource
#1Hakan CangulH-Index: 10
#2Xiao Hui LiaoH-Index: 30
Last. ren E
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