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Thomas Sauvigny
University of Hamburg
SurgeryNeurointensive careGlasgow Outcome ScaleAnesthesiaMedicine
14Publications
5H-index
66Citations
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Publications 19
Newest
#1Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
#2Malik Alawi (UHH: University of Hamburg)H-Index: 17
Last. Andre Franke (CAU: University of Kiel)H-Index: 87
view all 16 authors...
OBJECTIVE: Genetic risk factors for unruptured intracranial aneurysms (UIA) and aneurysmal subarachnoid hemorrhage (aSAH) are poorly understood. We aimed to verify recently reported risk genes and to identify novel sequence variants involved in the etiology of UIA/aSAH. METHODS: We performed exome sequencing (ES) in 35 unrelated individuals and 3 family members, each with a history of UIA and/or aSAH. We searched for sequence variants with minor allele frequency (MAF)
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#1Jennifer Göttsche (UHH: University of Hamburg)H-Index: 2
#2Friederike S. Fritzsche (UHH: University of Hamburg)H-Index: 1
Last. Jan Regelsberger (UHH: University of Hamburg)H-Index: 17
view all 6 authors...
Background and Study Aims/Objective Cranioplasty, a common neurosurgical intervention following decompressive craniectomy (DC), is associated with high complication rates. Bone flap resorption in particular leads to a considerable number of patients requiring further surgery. The aim of this study was to investigate the frequency and time of occurrence of complications following cranioplastic procedures in children and adults. Material and Methods Data of children and adults who underwent cranio...
Source
#1Franz Ricklefs (UHH: University of Hamburg)H-Index: 8
#2Cecile L. Maire (UHH: University of Hamburg)H-Index: 16
Last. Bob S. Carter (Harvard University)H-Index: 58
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Extracellular vesicles (EVs) are known for their important role in cancer progression and hold considerable potential as a source for tumor biomarkers. However, purification of tumor-specific EVs from patient plasma is still an urgent unmet need due to contamination by normal host cell-derived EVs, that results in compromised analytical sensitivity. Here we identified fatty acid synthase (FASN), a key lipogenic enzyme which is highly expressed in malignant glioma cells, to be elevated in CD63- a...
Source
#1Malte Mohme (UHH: University of Hamburg)H-Index: 6
#2Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
Last. Patrick Czorlich (UHH: University of Hamburg)H-Index: 8
view all 13 authors...
The pathophysiology of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH) is incompletely understood. Intrathecal activation of inflammatory immune cells is suspected to play a major role for the induction of DCI. The aim of this study is to identify immune cell subsets and mediators involved in the pathogenesis of DCI. We prospectively collected blood and CSF from 25 patients with aSAH at early and late time points. We performed multicolor flow cytometry of peripher...
Source
#1Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
#2Franz Ricklefs (UHH: University of Hamburg)H-Index: 8
Last. Nils Ole Schmidt (UHH: University of Hamburg)H-Index: 10
view all 7 authors...
Source
#1Lasse Dührsen (UHH: University of Hamburg)H-Index: 3
#2Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
Last. Tobias Martens (UHH: University of Hamburg)H-Index: 15
view all 8 authors...
In medical refractory temporal lobe epilepsy (TLE), the epileptogenic zone can be difficult to identify and therefore difficult to treat, especially in the absence of clear MRI pathologies and specific results from presurgical evaluation. Invasive monitoring with stereo-electroencephalography (sEEG) is a tool for a better determination of the epileptogenic zone. Here, we investigate the impact of sEEG on decision-making in temporal lobe epilepsy surgery. We reviewed patients with TLE who underwe...
Source
#1Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
#2Marie Teresa Nawka (UHH: University of Hamburg)
Last. Patrick Czorlich (UHH: University of Hamburg)H-Index: 8
view all 8 authors...
Background The Woven EndoBridge (WEB) device has been increasingly used for the treatment of intracranial aneurysms after aneurysmal subarachnoid hemorrhage (SAH). Still, recent major clinical trials on patient management after SAH have defined WEB embolization as an exclusion criterion. In an analysis of an unselected patient cohort, we evaluate the early clinical course of SAH patients after WEB treatment compared to those treated with endovascular coiling or surgical clipping.
Source
#1Thomas SauvignyH-Index: 5
#2Malte MohmeH-Index: 6
Last. Patrick CzorlichH-Index: 8
view all 9 authors...
Hyperactive delirium (agitation) is a common complication in patients on intensive care units and can be assessed by the Richmond Agitation and Sedation Scale (RASS) in principle. However, the role of agitation in patients with aneurysmal subarachnoid haemorrhage (SAH) is poorly understood. We performed a retrospective analysis to identify risk factors for the development of a hyperactive delirium and its functional consequences for neurological outcome. Three hundred thirty-eight patients with ...
2 CitationsSource
#1Lasse Dührsen (UHH: University of Hamburg)H-Index: 3
#2Thomas Sauvigny (UHH: University of Hamburg)H-Index: 5
Last. Tobias Martens (UHH: University of Hamburg)H-Index: 15
view all 9 authors...
1 CitationsSource
#1Thomas SauvignyH-Index: 5
#2Lasse DührsenH-Index: 3
Last. Tobias MartensH-Index: 15
view all 6 authors...
Source
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