Elisabeth B. Binder
Max Planck Society
Publications 494
#1Samuel A. McLean (UNC: University of North Carolina at Chapel Hill)H-Index: 28
#2Kerry J. Ressler (McLean Hospital)H-Index: 80
Last.Ronald C. Kessler (Harvard University)H-Index: 234
view all 68 authors...
Adverse posttraumatic neuropsychiatric sequelae (APNS) are common among civilian trauma survivors and military veterans. These APNS, as traditionally classified, include posttraumatic stress, postconcussion syndrome, depression, and regional or widespread pain. Traditional classifications have come to hamper scientific progress because they artificially fragment APNS into siloed, syndromic diagnoses unmoored to discrete components of brain functioning and studied in isolation. These limitations ...
1 CitationsSource
#1Cristiana Cruceanu (MPG: Max Planck Society)H-Index: 16
#2Leander Dony (MPG: Max Planck Society)H-Index: 1
Last.E. Binder (MPG: Max Planck Society)H-Index: 6
view all 18 authors...
A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing health outcomes. Excess GR-activation in utero has been linked to brain-related negative outcomes, with unclear underlying mechanisms, especially regarding cell-type specific effects. To address this, we used an in vitro model of fetal human brain, induced pluripotent-stem-cell-derived cerebral organoids, and mapped GR-activation effects using single-cell transcriptomic...
#1Lilia Papst (MPG: Max Planck Society)
#2Elisabeth B. Binder (MPG: Max Planck Society)H-Index: 75
Abstract Throughout life, the developing organism is shaped by a combination of genetic disposition and environmental circumstances exerting differential effects on mental health. The key factors either promoting risk or resilience change throughout the life span, starting with cortisol levels in the womb, physical contact in infancy, and going from adversity and model learning in childhood to stressful life events and social support in adulthood. Genetic variability associated with key systems ...
#1Caitlin G. Howe (SC: University of Southern California)H-Index: 6
#2Bianca Cox (University of Hasselt)H-Index: 21
Last.Carrie V. Breton (SC: University of Southern California)H-Index: 27
view all 38 authors...
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that the epigenome may play a role, but most previous studies have been small and adjusted for few covariates. The current study meta-analyzed the association between maternal GDM and cord blood DNA methylation in the Pregnancy and Childhood Epigenetics (PACE) consortium. RESEARCH DESIGN AND METHODS Seven pregnancy cohorts (3,677 mother-newborn pairs [317 w...
#1Mara Thomas (University of Tübingen)H-Index: 3
#2Andressa Coope (SFU: Simon Fraser University)
Last.Vanessa NieratschkerH-Index: 19
view all 11 authors...
Abstract Early life stress (ELS) is associated with an increased risk of depression and this association may be mediated by epigenetic mechanisms. A previous epigenome-wide DNA methylation (DNAm) study investigating human newborns and two animal models of ELS suggested that the epigenetic regulator MORC1 is differentially methylated following ELS. The ELS-induced DNAm alterations were long-lasting in the animal models. However, whether this finding is also transferable to humans experiencing ELS...
#1Tianye Jia (Fudan University)H-Index: 14
#2Congying Chu ('KCL': King's College London)H-Index: 2
Last.Sylvane Desrivières ('KCL': King's College London)H-Index: 25
view all 82 authors...
DNA methylation, which is modulated by both genetic factors and environmental exposures, may offer a unique opportunity to discover novel biomarkers of disease-related brain phenotypes, even when measured in other tissues than brain, such as blood. A few studies of small sample sizes have revealed associations between blood DNA methylation and neuropsychopathology, however, large-scale epigenome-wide association studies (EWAS) are needed to investigate the utility of DNA methylation profiling as...
2 CitationsSource
#1Alex Ing ('KCL': King's College London)H-Index: 3
#2P. Saemann (MPG: Max Planck Society)H-Index: 32
Last.Gunter SchumannH-Index: 51
view all 50 authors...
Most psychopathological disorders develop in adolescence. The biological basis for this development is poorly understood. To enhance diagnostic characterization and develop improved targeted interventions, it is critical to identify behavioural symptom groups that share neural substrates. We ran analyses to find relationships between behavioural symptoms and neuroimaging measures of brain structure and function in adolescence. We found two symptom groups, consisting of anxiety/depression and exe...
#1Tobias Wiechmann (MPG: Max Planck Society)H-Index: 4
#2Simone Röh (MPG: Max Planck Society)H-Index: 5
Last.Nadine Provencal (SFU: Simon Fraser University)H-Index: 8
view all 11 authors...
Background Epigenetic mechanisms may play a major role in the biological embedding of early-life stress (ELS). One proposed mechanism is that glucocorticoid (GC) release following ELS exposure induces long-lasting alterations in DNA methylation (DNAm) of important regulatory genes of the stress response. Here, we investigate the dynamics of GC-dependent methylation changes in key regulatory regions of the FKBP5 locus in which ELS-associated DNAm changes have been reported.
#1Laurel Raffington (University of Texas at Austin)H-Index: 2
#2Laurel Raffington (University of Texas at Austin)
Last.Yee Lee Shing (Goethe University Frankfurt)H-Index: 19
view all 8 authors...
Abstract Despite common notion that the correlation of socioeconomic status with child cognitive performance may be driven by both environmentally– and genetically–mediated transactional pathways, there is a lack of longitudinal and genetically informed research that examines these postulated associations. The present study addresses whether family income predicts associative memory growth and hippocampal development in middle childhood and tests whether these associations persist when controlli...